Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kazumichi M. Nishida"'
Autor:
Hiroya Yamazaki, Yurika Namba, Shogo Kuriyama, Kazumichi M. Nishida, Asako Kajiya, Mikiko C. Siomi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Bombyx Vasa assembles Vasa bodies, the site of transposon silencing by Siwi and Ago3-piRISC formation. Here, the authors show Vasa sequesters transposon mRNAs in Vasa bodies via phase separation requiring RNA binding and self-association of Vasa.
Externí odkaz:
https://doaj.org/article/0042f9a59af34a1387db541dad9dcefc
Autor:
Hiromi Yamada, Kazumichi M. Nishida, Yuka W. Iwasaki, Yosuke Isota, Lumi Negishi, Mikiko C. Siomi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Siwi-piRISC protects the germline genome from DNA damage caused by selfish movement of transposons by suppressing their expression. Here, the authors show how molecularly Papi, which plays an important role in the production of Siwi-piRISC, cooperate
Externí odkaz:
https://doaj.org/article/25e88a75d92b4be1a12a3a1045ee983f
Autor:
Yurika Namba, Yuka W. Iwasaki, Kazumichi M. Nishida, Hidenori Nishihara, Tetsutaro Sumiyoshi, Mikiko C. Siomi
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103914- (2022)
Summary: PIWI-interacting RNAs (piRNAs) bind to PIWI proteins to assemble the piRISC, which represses germline transposons. Maelstrom (Mael) is necessary for piRISC biogenesis in germ cells, but its function remains unclear. Here, we show that Mael i
Externí odkaz:
https://doaj.org/article/db07349de2f149349d5428e9be6ab5fe
Autor:
Sonomi Yamaguchi, Akira Oe, Kazumichi M. Nishida, Keitaro Yamashita, Asako Kajiya, Seiichi Hirano, Naoki Matsumoto, Naoshi Dohmae, Ryuichiro Ishitani, Kuniaki Saito, Haruhiko Siomi, Hiroshi Nishimasu, Mikiko C. Siomi, Osamu Nureki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
PIWI-clade Argonautes bind PIWI-interacting RNAs (piRNAs) to silence transposons and maintain genome integrity in animal gonads. Here the authors present the crystal structure of a Drosophila Piwi–piRNA complex isolated from cultured fly ovarian so
Externí odkaz:
https://doaj.org/article/9479ad5dbf9b4bffacfb69fcd7468085
Autor:
Kazumichi M. Nishida, Yuka W. Iwasaki, Yukiko Murota, Akihiro Nagao, Taro Mannen, Yumiko Kato, Haruhiko Siomi, Mikiko C. Siomi
Publikováno v:
Cell Reports, Vol 10, Iss 2, Pp 193-203 (2015)
PIWI-interacting RNA (piRNA) biogenesis consists of two sequential steps: primary piRNA processing and the ping-pong cycle that depends on reciprocal Slicer-mediated RNA cleavage by PIWI proteins. However, the molecular functions of the factors invol
Externí odkaz:
https://doaj.org/article/41f41e708c004047b3742b8f78b88269
Autor:
Seiichi Hirano, Hiroshi Nishimasu, Akira Oe, Kazumichi M. Nishida, Keitaro Yamashita, Haruhiko Siomi, Asako Kajiya, Mikiko C. Siomi, Kuniaki Saito, Osamu Nureki, Sonomi Yamaguchi, Naoki Matsumoto, Ryuichiro Ishitani, Naoshi Dohmae
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
PIWI-clade Argonaute proteins associate with PIWI-interacting RNAs (piRNAs), and silence transposons in animal gonads. Here, we report the crystal structure of the Drosophila PIWI-clade Argonaute Piwi in complex with endogenous piRNAs, at 2.9 Å reso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3d62d19fd6b93871a929e09c5d806a
http://link.springer.com/article/10.1038/s41467-020-14687-1
http://link.springer.com/article/10.1038/s41467-020-14687-1
Autor:
Yurika, Namba, Yuka W, Iwasaki, Kazumichi M, Nishida, Hidenori, Nishihara, Tetsutaro, Sumiyoshi, Mikiko C, Siomi
Publikováno v:
iScience. 25(3)
PIWI-interacting RNAs (piRNAs) bind to PIWI proteins to assemble the piRISC, which represses germline transposons. Maelstrom (Mael) is necessary for piRISC biogenesis in germ cells, but its function remains unclear. Here, we show that Mael interconne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::564a43bdab43d74fcf1341cf8d5339fc
https://pubmed.ncbi.nlm.nih.gov/35243263
https://pubmed.ncbi.nlm.nih.gov/35243263
Autor:
Hiromi Yamada, Kazumichi M. Nishida, Yuka W. Iwasaki, Yosuke Isota, Lumi Negishi, Mikiko C. Siomi
Publikováno v:
Nature communications. 13(1)
Bombyx Papi acts as a scaffold for Siwi-piRISC biogenesis on the mitochondrial surface. Papi binds first to Siwi via the Tudor domain and subsequently to piRNA precursors loaded onto Siwi via the K-homology (KH) domains. This second action depends on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e924da0eb166f69ae1025506da67fc
https://pubmed.ncbi.nlm.nih.gov/35314687
https://pubmed.ncbi.nlm.nih.gov/35314687
Autor:
Takeshi Kawamura, Kazumichi M. Nishida, Mikiko C. Siomi, Kazuhiro Sakakibara, Hiroya Yamazaki, Taro Mannen, Tetsutaro Sumiyoshi, Tatsuhiko Kodama
Publikováno v:
The EMBO Journal
Silkworm ovarian germ cells produce the Siwi‐piRNA‐induced silencing complex (piRISC) through two consecutive mechanisms, the primary pathway and the secondary ping‐pong cycle. Primary Siwi‐piRISC production occurs on the outer mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60761443f1ce19f127e3a624e82524f
http://europepmc.org/articles/PMC7560202
http://europepmc.org/articles/PMC7560202
Autor:
Asuka Ogai, Haruhiko Siomi, Mikiko C. Siomi, Soichiro Yamanaka, Kazumichi M. Nishida, Lumi Negishi, Ryu Yashiro, Kaede Fujii, Haruna Yamashiro, Yukiko Murota
Publikováno v:
Cell reports. 23(12)
In Drosophila ovarian somatic cells (OSCs), Piwi represses transposons transcriptionally to maintain genome integrity. Piwi nuclear localization requires the N terminus and PIWI-interacting RNA (piRNA) loading of Piwi. However, the underlying mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e431db28b598afa2196e24c31bc176c7
https://pubmed.ncbi.nlm.nih.gov/29925005
https://pubmed.ncbi.nlm.nih.gov/29925005