Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kazumi Urakawa"'
Autor:
Yasuhisa Takeda, Kenichi Akamatsu, Kazumi Urakawa, Akinori Kawamura, Nobuhiro Takagi, Masahiko Mihara
Publikováno v:
European Journal of Pharmacology. 435:237-244
N-[[4-[(2,4-diaminopteridin-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]-carbonyl]-L-homoglutamic acid (MX-68), a derivative of methotrexate, was chemically designed to resist polyglutamation and to have a high affinity for dihydrofolate reduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be0f2a0022d11e15efe0d4a35107c1b
https://doi.org/10.1016/s0014-2999(01)01553-9
https://doi.org/10.1016/s0014-2999(01)01553-9
Publikováno v:
International Journal of Immunopharmacology. 19:67-74
We evaluated the preventive effects of a novel nonpolyglutamatable antifolate, MX-68, on two experimental murine models of systemic lupus erythematosus (SLE); NZBxNZW F1 (BWF1) mice and chronic graft-versus-host disease (GVHD) mice, in comparison wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76578fa5ae3a11d76a6958293a3bb65
https://doi.org/10.1016/s0192-0561(97)00015-5
https://doi.org/10.1016/s0192-0561(97)00015-5
Autor:
Kazumi Urakawa, Toshiyuki Hamaoka, Shinya Murakami, Yasuhisa Takeda, Shiro Ono, Yutaka Sugawara, Fumiya Hirayama, Yoshiyuki Ohsugi, Keiko Nakamura, Akemi Sakamoto, Masahiko Mihara, Toshiaki Nakano
Publikováno v:
Ensho. 10:465-469
Lobenzarit disodium (CCA) is an immunomodulating anti-rheumatic drug, and is reported to show inhibitory effects on B-cell activation. To further analyze the direct effects of CCA on B cells, we examined the effects of CCA on Ig-production in vitro b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73a94a93ef00821cfb1ccd5f69920665
https://doi.org/10.2492/jsir1981.10.465
https://doi.org/10.2492/jsir1981.10.465
Autor:
Takashi Suzuki, Naoyuki Kamatani, Akinori Kawamura, Masahiko Mihara, Yasuhisa Takeda, Kenichi Akamatsu, Kazumi Urakawa
Publikováno v:
Immunopharmacology. 48(2)
Methotrexate (MTX) exerts an anti-inflammatory effect, reportedly by enhancing the release of adenosine, through an accumulation of 5-amino-4-imidazolecarboxamide ribonucleotide (AICAR). To examine the role of polyglutamation in promoting anti-inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cccf49b996a576230f02472d54720f3a
https://pubmed.ncbi.nlm.nih.gov/10936511
https://pubmed.ncbi.nlm.nih.gov/10936511
Publikováno v:
International archives of allergy and immunology. 113(4)
We compared a novel unpolyglutamable antifolate, MX-68, with polyglutamable antifolate, methotrexate (MTX), for treatment of an autoimmune kidney disease which develops spontaneously in MRL/Mp-lpr/lpr (MRL/lpr) mice. Oral administration of either MX-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ccb655168f23fe510a5019899fe0f1d
https://pubmed.ncbi.nlm.nih.gov/9250591
https://pubmed.ncbi.nlm.nih.gov/9250591
Publikováno v:
Immunopharmacology. 35(1)
MX-68 is a newly synthesized anti-folate, chemically designed not to undergo intracellular polyglutamation and to have increased affinity to dihydrofolate reductase (DHFR). In the present study, we examined the in vitro and in vivo biological activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc9d3e42a84092ec7934ba62257e379
https://pubmed.ncbi.nlm.nih.gov/8913793
https://pubmed.ncbi.nlm.nih.gov/8913793
Autor:
Ryo Okazaki, Toshiaki Nakano, Tomoko Kikuchi, Kazumi Urakawa, Kyoji Ikeda, Kyoko Morimoto, Toshio Matsumoto, Etsuro Ogata, Akemi Sakamoto
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 7(10)
The present study was undertaken to clarify the relationship between c-fos and c-jun protooncogene expression and the differentiation and/or proliferation of osteoblasts, using osteoblast-like MC3T3-E1 (E1) cells. c-fos mRNA was barely detectable, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f0b5efedd4e8590d13e2532440d9f0
https://pubmed.ncbi.nlm.nih.gov/1456083
https://pubmed.ncbi.nlm.nih.gov/1456083
Autor:
Yasuhisa Takeda, Akemi Sakamoto, Toshiaki Nakano, Kazumi Urakawa, Mamoru Morita, Tadashi Kasahara, Yutaka Sugawara, Yoshiyuki Ohsugi
Publikováno v:
Chemicalpharmaceutical bulletin. 40(1)
The regulatory effects of lobenzarit disodium (CCA), a therapeutic agent for treating rheumatoid arthritis (RA), on polyclonal immunoglobulin production by human lymphocytes were investigated in vitro. CCA inhibited the production of immunoglobulin i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5343e7f0375383125f0719af674776b
https://pubmed.ncbi.nlm.nih.gov/1576670
https://pubmed.ncbi.nlm.nih.gov/1576670
Autor:
Donald W. MacGlashan, Hans-Hartmut Peter, Marina Di Fonso, Françoise Maynard, Emiko Noguchi, F. Giuffreda, Nobuyuki Takagi, Michael D. Spangfort, K. Becker, Yuji Mori, N. Kofler, Mikiko Yabe, Dieter Häussinger, Bodo Grimbacher, Masahiko Mihara, I.G. Reischl, Ann M. Dvorak, Per Hultman, Antonino Romano, C. Rieser, C. Ruedl, Kazumi Urakawa, Paolo Zeppilli, Lawrence M. Lichtenstein, H. Wolf, K. Jung, Jacques Banchereau, J. Unger, Emanuele Fanales-Belasio, Jean-Michel Wal, Rolf Jost, R. Linse, A. Venuti, Ellen S. Morgan, Helén Hansson-Georgiadis, Cees van Kooten, Vincenzo Palmieri, Tom H.M. Ottenhoff, Peter H. Nibbering, Eric Spierings, G. Wick, Jane Warner, Yasuhisa Takeda, Fernando Aiuti, Thomas Peters, B.A. Imhof, Thomas Südhoff, N. Corvaïa, Masashi Tatsumi, U. Wollina, Ignacio J. Ansotegui, M. Woisetschläger, Roberto Paganelli, Hans Reinauer, Yoichiro Moriya, Michael Heins, Rolien de Jong, Ruth-Maria Korth, Linda Letourneau, Yoshiharu Matsuura, Haruka Takakura, C. Neumann, Uno Johansson, Steven J. Ackerman, Masanao Shibasaki, G.C. Mudde
Publikováno v:
International Archives of Allergy and Immunology. 113:I-II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa4d1ca6876c8dbe1806de4f6edb4a37
https://doi.org/10.1159/000237613
https://doi.org/10.1159/000237613
Autor:
Yasuhisa Takeda, Bodo Grimbacher, I.G. Reischl, Michael Heins, Jean-Michel Wal, Michael D. Spangfort, Rolien de Jong, Peter H. Nibbering, Cees van Kooten, Helén Hansson-Georgiadis, Thomas Peters, Uno Johansson, B.A. Imhof, N. Kofler, G. Wick, K. Becker, M. Woisetschläger, Ann M. Dvorak, Masahiko Mihara, Ignacio J. Ansotegui, Ruth-Maria Korth, F. Giuffreda, K. Jung, C. Rieser, Rolf Jost, Thomas Südhoff, Masashi Tatsumi, Steven J. Ackerman, Nobuyuki Takagi, Kazumi Urakawa, Paolo Zeppilli, U. Wollina, Yoichiro Moriya, Roberto Paganelli, Hans Reinauer, Yoshiharu Matsuura, Vincenzo Palmieri, A. Venuti, Ellen S. Morgan, Tom H.M. Ottenhoff, N. Corvaïa, Eric Spierings, Jane Warner, C. Neumann, R. Linse, Fernando Aiuti, Yuji Mori, H. Wolf, Jacques Banchereau, Lawrence M. Lichtenstein, Linda Letourneau, Haruka Takakura, G.C. Mudde, Masanao Shibasaki, Emanuele Fanales-Belasio, Dieter Häussinger, Per Hultman, Antonino Romano, C. Ruedl, J. Unger, Donald W. MacGlashan, Hans-Hartmut Peter, Françoise Maynard, Marina Di Fonso, Emiko Noguchi, Mikiko Yabe
Publikováno v:
International Archives of Allergy and Immunology. 113:520-520
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61b78a6f17b4145f228e3b27e9402358
https://doi.org/10.1159/000237634
https://doi.org/10.1159/000237634