Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kazumi Tashiro"'
Autor:
Shingo Makino, Masataka Shoji, Takashi Kayahara, Takashi Tsuji, Kazumi Tashiro, Mitsuo Takahashi
Publikováno v:
Journal of Computer-Aided Molecular Design. 15:553-559
We report a set of strategies to develop novel ligands (Structure Based and Experimental Selection of Fragments: SbE-SF). First, a docking simulation utilizing DOCK3.5 is performed in order to screen the fragment database, which was generated with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e2fc2620bdd5269efc93f42a187ab50
https://doi.org/10.1023/a:1011196407163
https://doi.org/10.1023/a:1011196407163
Autor:
Seiji Oono, Kazumi Tashiro, Mitsuo Takahashi, Seinosuke Iwata, Yumiko Fukuda, Koichi Fujita, Masahiro Yamanashi, Masayuki Sugiki, Kazuyuki Sagi, Masataka Shoji, Akiko Okajima, Kuniya Sakurai, Shunji Takehana, Takashi Kayahara
Publikováno v:
Bioorganicmedicinal chemistry. 13(5)
An inhibitor of the complex of factor VIIa and tissue factor (fVIIa/TF), 2-substituted-4-amidinophenylpyruvic acid 1a, was structurally modified with the aim of increasing its potency and selectivity. The lead compound 1a was originally found in our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4429f1820a9a75523b0e5234fa96aff
https://pubmed.ncbi.nlm.nih.gov/15698764
https://pubmed.ncbi.nlm.nih.gov/15698764
Autor:
Yoichiro Shima, Seinosuke Iwata, Shingo Makino, Masataka Shoji, Noriyasu Kataoka, Mitsuo Takahashi, Tadakiyo Nakagawa, Hiroshi Yamamoto, Suzuki Nobuyasu, Seiji Oono, Shunji Takehana, Kazumi Tashiro, Takashi Kayahara, Takashi Tsuji, Ryota Yoshimoto, Kazuyuki Sagi, Masahiro Yamanashi, Kohki Ishikawa, Yumiko Fukuda, Masaru Takayanagi, Kaoru Takenaka, Sayaka Shima, Kuniya Sakurai
Publikováno v:
Journal of medicinal chemistry. 46(10)
An inhibitor of factor Xa (fXa), the m-substituted benzamidine AXC1578 (1a), was structurally modified with the aim of increasing its potency. In particular, pyruvic acid and propionic acid substituents were incorporated into the P1 benzamidine moiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767eb5e6a06e41647edd2dc14f8255b0
https://pubmed.ncbi.nlm.nih.gov/12723948
https://pubmed.ncbi.nlm.nih.gov/12723948