Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kazumi Morikawa"'
Autor:
Kwangseok Ko, Chan Hee Park, Seung-Su Oh, Young Jin Kwon, Jung-Sook Kim, Eun-Jung Park, Woul-Seong Park, Soon Ok Lee, D.H. Yoon, Woon-Ki Cho, Yu-Mi Song, Kyoung-June Lee, Cho-Rong Min, Jieun Lee, Kazumi Morikawa, Ju-Han Yoon, Pil-Su Ho, Hye Jung Kim, Jee-Hun Yun, Yu Chul Kim
Publikováno v:
Journal of Medicinal Chemistry. 61:2949-2961
The histamine H4 receptor (H4R), a member of the G-protein coupled receptor family, has been considered as a potential therapeutic target for treating atopic dermatitis (AD). A large number of H4R antagonists have been disclosed, but no efficient age
Autor:
Tsutomu Sato, Naoki Taka, Masahiro Nishimoto, Takamitsu Kobayashi, Hitoshi Hagita, Motohiro Kato, Kazumi Morikawa, Keisuke Yamamoto, Koji Yamaguchi, Masatoshi Murakata, Masayuki Suzuki, Masayuki Ohmori, Sachiya Ikeda, Nobuo Shimma, Hiroharu Matsuoka, Yoshihito Ohtake, Kazuharu Ozawa, Koji Takano, Takashi Higuchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:5334-5341
5a-Carba-β-D-glucopyranose derivatives were synthesized and identified as novel SGLT2-selective inhibitors. These inhibitors exhibited potent SGLT2 inhibition with high selectivity over SGLT1. Among the tested compounds, 6f indicated the most potent
Autor:
Masumi Serizawa, Takaaki Uda, Kazumi Morikawa, Takashi Oki, Noboru Uehashi, Yasutsugu Kanda, Takashi Fukumoto
Publikováno v:
Journal of Japan Society of Civil Engineers, Ser. B2 (Coastal Engineering). 65:571-575
Beach changes around an artificial reef with crests on the Kaike coast were investigated through field observations, and compared with the beach changes around the detached breakwaters. Strong shoreward currents were induced due to wave breaking on t
Publikováno v:
PROCEEDINGS OF CIVIL ENGINEERING IN THE OCEAN. 24:1165-1170
Autor:
Tadakatsu Takahashi, Kazumi Morikawa
Publikováno v:
Current Topics in Medicinal Chemistry. 6:1303-1316
1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) is an important hormone that regulates metabolism of calcium and phosphorus in small intestine, kidney, and bone, and its physiological action is expressed as ligand-dependent transcription activity mediate
Autor:
Tetsuhiro Mikami, Atsuko Sugita, Hitoshi Shimizu, Tsuyoshi Yamauchi, Kazuki Shimizu, Yasushi Uchiyama, Masahiro Kato, Kazumi Morikawa
Publikováno v:
Tetrahedron Letters. 45:7837-7841
Two 21-nor-22-oxa-1α,25-dihydroxyvitamin D 3 derivatives have been synthesized in quest of a drug with lower calcemic activity than Maxacalcitol, 22-oxa-1α,25-dihydroxyvitamin D 3 , being used as antihyperparathyroidism and antipsoriatic drug. Of t
Autor:
Akira Kawase, Yoshihiko Ishitani, Hiroyoshi Watanabe, Tetsuya Mitsui, Noboru Kubodera, Ken Okano, Kazumi Morikawa
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 42:519-525
The synthesis of tritiated 1α-25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71), [2β-(3-3H)]ED-71 ((3) and [26,27-3H6]ED-71 (4) is described. The former was prepared by reduction of a precausor containing a formyl group in the A-ring part with
Autor:
Motohiro Kato, Masayuki Suzuki, Naoki Taka, Masayuki Ohmori, Hiroharu Matsuoka, Keisuke Yamamoto, Koo-Hyeon Ahn, Kazumi Morikawa, Sang-Yong Yeu, Marina Yamaguchi, Hitoshi Hagita, Sachiya Ikeda, Koji Takano, Koji Yamaguchi, Tsutomu Sato, Takamitsu Kobayashi, Kazuharu Ozawa, Masahiro Nishimoto, Kyoko Takami, Yoshihito Ohtake
Publikováno v:
Journal of medicinal chemistry. 55(17)
Inhibition of sodium glucose cotransporter 2 (SGLT2) has been proposed as a novel therapeutic approach to treat type 2 diabetes. In our efforts to discover novel inhibitors of SGLT2, we first generated a 3D pharmacophore model based on the superposit
Autor:
Nobuo Shimma, Hiroharu Matsuoka, Motohiro Kato, Keisuke Yamamoto, Masahiro Nishimoto, Tsutomu Sato, Masayuki Ohmori, Takashi Higuchi, Naoki Taka, Sachiya Ikeda, Hitoshi Hagita, Masayuki Suzuki, Kazuharu Ozawa, Yoshihito Ohtake, Koji Yamaguchi, Masatoshi Murakata, Takamitsu Kobayashi, Kazumi Morikawa, Koji Takano
Publikováno v:
Bioorganicmedicinal chemistry. 20(13)
C-Aryl 5a-carba-β-d-glucopyranose derivatives were synthesized and evaluated for inhibition activity against hSGLT1 and hSGLT2. Modifications to the substituents on the two benzene rings resulted in enhanced hSGLT2 inhibition activity and extremely
Autor:
William Alazawi, Masayuki Sudoh, Michinori Kohara, Nobuo Shimma, Atsunori Ohta, Mikio Arisawa, Yuko Aoki, Asao Katsume, Natsuko Hada, Hitoshi Yoshino, Hiroshi Ohmori, Yuichi Hirata, Hiroshi Sakamoto, Kazumi Morikawa, Takuo Tsukuda, Motooki Ashihara, Yusuke Ohmori, Koichi Okamoto, Hideyuki Konishi, Graham R. Foster
Publikováno v:
Scientific Reports
Most acute hepatitis C virus (HCV) infections become chronic and some progress to liver cirrhosis or hepatocellular carcinoma. Standard therapy involves an interferon (IFN)-α-based regimen, and efficacy of therapy has been significantly improved by