Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Kazumi Ishidoh"'
Autor:
Norio Kamemura, Keisuke Oyama, Shinya Ueno, Mizuki Mizobuchi, Kazumi Ishidoh, Naoki Kanematsu
Publikováno v:
Journal of Tropical Pharmacy and Chemistry, Vol 5, Iss 2 (2020)
Thiopental is an ultra-short-acting barbiturate and has been used commonly in the induction phase of general anesthesia. However, the toxic effect of thiopental is not completely clear.?The effect of thiopental on intracellular Ca2+ ([Ca2+]i) levels
Externí odkaz:
https://doaj.org/article/018a6082627f448680e2d8953bac0ade
Publikováno v:
Drug and Chemical Toxicology. 45:1899-1906
Butylated hydroxyanisole (BHA) and the chemically similar butylated hydroxytoluene (BHT) are widely used as antioxidants. Toxicity of BHA and BHT has been reported under in vitro and in vivo experimental conditions. However, the mechanism of BHA-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b89151cc860b383197a5e4a4c52bafe
https://doi.org/10.1080/01480545.2021.1894701
https://doi.org/10.1080/01480545.2021.1894701
Autor:
Mizuki Mizobuchi, Naoki Kanematsu, Kazumi Ishidoh, Keisuke Oyama, Shinya Ueno, Norio Kamemura
Publikováno v:
Journal of Tropical Pharmacy and Chemistry. 5:130-137
Thiopental is an ultra-short-acting barbiturate and has been used commonly in the induction phase of general anesthesia. However, the toxic effect of thiopental is not completely clear. The effect of thiopental on intracellular Ca2+ ([Ca2+]i) levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f241a23cc56c135a6f1165a7f33c6c22
https://doi.org/10.25026/jtpc.v5i2.259
https://doi.org/10.25026/jtpc.v5i2.259
Autor:
Takeshi Nikawa, Kazumi Ishidoh
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics. 1868(11)
This review focuses on the Cbl-b muscle atrophy-associated ubiquitin ligase and its inhibitors. Herein, the role of E3 ubiquitin ligase-associated muscle atrophy genes (atrogenes), including MAFbx-1/agrogin-1 and MuRF-1, as well as another ubiquitin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5678aa2ca35f85bc670e439b18e139c
https://pubmed.ncbi.nlm.nih.gov/32663526
https://pubmed.ncbi.nlm.nih.gov/32663526
Autor:
Kazumi Ishidoh, Yu Sasaki, Miyuki Takagi, Ayano Kubo, Isao Shirato, Katsuhiko Asanuma, Yusuke Suzuki, Teruo Hidaka
Publikováno v:
Journal of Histochemistry & Cytochemistry. 66:863-877
Cathepsin L, a lysosomal cysteine proteinase, may have a key role in various biological and disease processes by intracellular and extracellular degradation of proteins. We examined the levels of cathepsin L and its intrinsic inhibitors in glomeruli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e675bb34fe3cd98d0cab26d90fba2a
https://doi.org/10.1369/0022155418791822
https://doi.org/10.1369/0022155418791822
Autor:
Hiroaki Komatsu, Koji Kishimoto, Sara Murakami, Keizo Yuasa, Masahiro Sawanoi, Kazumi Ishidoh, Kenji Miyamoto, Akihiko Tsuji, Norio Kamemura
Publikováno v:
Biochemical and Biophysical Research Communications. 483(1):82-87
Although type II cGMP-dependent protein kinase (PKGII) is a major downstream effector of cGMP in chondrocytes and attenuates the FGF receptor 3/ERK signaling pathway, its direct target proteins have not been fully explored. In the present study, we a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86ebe28add6782182ef5d1a5ead3349
https://repo.lib.tokushima-u.ac.jp/111887
https://repo.lib.tokushima-u.ac.jp/111887
Publikováno v:
Toxins; Volume 10; Issue 5; Pages: 209
Clostridium perfringens iota-toxin is a binary actin-ADP-ribosylating toxin composed of the enzymatic component Ia and receptor binding component Ib. Ib binds to a cell surface receptor, forms Ib oligomer in lipid rafts, and associates with Ia. The I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1965a3d01dfcadd147203866149136af
Autor:
Kazumi Ishidoh, Keiko Kobayashi, Jun Sakurai, Yoshihiko Sakaguchi, Chihiro Takahashi, Masahiro Nagahama, Kouhei Aoyanagi, Ryo Tashiro
Publikováno v:
Toxicon. 82:76-82
Clostridium botulinum C2 toxin is a binary toxin composed of an enzymatic component (C2I) and binding component (C2II). The activated binding component (C2IIa) forms heptamers and the oligomer with C2I is taken up by receptor-mediated endocytosis. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b85138fbbe5bf993d408abb2c0c712
https://doi.org/10.1016/j.toxicon.2014.02.009
https://doi.org/10.1016/j.toxicon.2014.02.009
Autor:
Kazumi Ishidoh, Jia-Guo Rong, Hui-Ling Zhang, Zhong-Sheng Li, Yong Ni, Gu Weiwei, Lei Yang, Yu Luo, Min Xu, Nobuhiko Katunuma
Publikováno v:
Glia. 62:855-880
The roles of cathepsins in the ischemic astrocytic injury remain unclear. Here, we test the hypothesis that activation of cathepsin B and L contributes to the ischemic astrocyte injury via the tBid-mitochondrial apoptotic signaling pathways. In the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ee2e6e5b4f3d12bce8d9937b4d6a12c
https://doi.org/10.1002/glia.22645
https://doi.org/10.1002/glia.22645
Autor:
Shi-chang Sun, Kazumi Ishidoh, Qiang Zhou, Gu Weiwei, Jia-hong Fan, Katunuma Nobuhiko, Hui-Ling Zhang, Guizhen Ao, Yong-Ming Zhu, Xiu-mei Gao
Publikováno v:
Acta Pharmacologica Sinica. 34:1007-1012
2-(3′,5′-Dimethoxybenzylidene) cyclopentanone (DMBC) is a novel synthetic compound with antinociceptive activities. The aim of this study was to investigate the roles of the autophagic-lysosomal pathway in the antinociceptive effect of DMBC in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40add27ad136ce77b46542efb9032ea
https://doi.org/10.1038/aps.2013.30
https://doi.org/10.1038/aps.2013.30