Výsledky vyhledávání - "Kazumi Ebine"

Akademický článek

Three-dimensional collagen I promotes gemcitabine resistance in vitro in pancreatic cancer cells through HMGA2-dependent histone acetyltransferase expression.

Autor: Surabhi Dangi-Garimella, Vaibhav Sahai, Kazumi Ebine, Krishan Kumar, Hidayatullah G Munshi

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64566 (2013)

Pancreatic ductal adenocarcinoma (PDAC) is associated with a pronounced collagen-rich stromal reaction that has been shown to contribute to chemo-resistance. We have previously shown that PDAC cells are resistant to gemcitabine chemotherapy in the co

Externí odkaz: https://doaj.org/article/00b4e8702e0c4465b6d21129df6bb747

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Supplemental Data from Differential Regulation of ZEB1 and EMT by MAPK-Interacting Protein Kinases (MNK) and eIF4E in Pancreatic Cancer

Autor: Hidayatullah G. Munshi, Leonidas C. Platanias, Frank D. Eckerdt, David J. Bentrem, Benjamin Kwok, Ahmet D. Arslan, Kazumi Ebine, Christina R. Chow, Krishan Kumar

Supplemental data related to Figs. 2 and 5 S1. Collagen-dependent MNK phosphorylation in chemoresistant PDAC cells. S2. Targeting eIF4E increases ZEB1 levels in AsPC1 and Panc1 cells. S3. eIF4E and MNK1/2 do not regulate expression of primary transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be63e228a6b19c28aeee8cca2ac0cd77
https://doi.org/10.1158/1541-7786.22512103

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Data from Differential Regulation of ZEB1 and EMT by MAPK-Interacting Protein Kinases (MNK) and eIF4E in Pancreatic Cancer

Autor: Hidayatullah G. Munshi, Leonidas C. Platanias, Frank D. Eckerdt, David J. Bentrem, Benjamin Kwok, Ahmet D. Arslan, Kazumi Ebine, Christina R. Chow, Krishan Kumar

Human pancreatic ductal adenocarcinoma (PDAC) tumors are associated with dysregulation of mRNA translation. In this report, it is demonstrated that PDAC cells grown in collagen exhibit increased activation of the MAPK-interacting protein kinases (MNK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79ea5e59f133a66cea6a0284bf6fd4dd
https://doi.org/10.1158/1541-7786.c.6540127.v1

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Adobe PDF - MCT-13-0925_fig_leg_fig_1_to_7.pdf from BET Bromodomain Inhibitors Block Growth of Pancreatic Cancer Cells in Three-Dimensional Collagen

Autor: Hidayatullah G. Munshi, Kazumi Ebine, David J. Bentrem, Sania S. Raza, Christina R. Chow, Lawrence M. Knab, Krishan Kumar, Vaibhav Sahai

PDF - 1346K, Fig. S1: Effect of I-BET151 on PDAC cells. Figs. S2 and S3: Effect of I-BET on Snail-expressing PDAC cells. Fig. S4: Effect of I-BET151 on chemo-resistant cells. Figs. S5 and S6: Effect of I-BET151 on c-MYC and FOSL1. Fig. S7: ChIP resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3015192c0d4d4644e8a8556b9a354ad1
https://doi.org/10.1158/1535-7163.22501249

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Data from BET Bromodomain Inhibitors Block Growth of Pancreatic Cancer Cells in Three-Dimensional Collagen

Autor: Hidayatullah G. Munshi, Kazumi Ebine, David J. Bentrem, Sania S. Raza, Christina R. Chow, Lawrence M. Knab, Krishan Kumar, Vaibhav Sahai

Pancreatic ductal adenocarcinoma (PDAC) is associated with pronounced fibrosis that contributes to chemoresistance, in part, through increased histone acetylation. Because bromodomain (BRD) and extra terminal domain (BET) proteins are “readers” o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21129da4558de98cc41e33f14747f8e1
https://doi.org/10.1158/1535-7163.c.6536722.v1

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Induction of MNK Kinase–dependent eIF4E Phosphorylation by Inhibitors Targeting BET Proteins Limits Efficacy of BET Inhibitors

Autor: Hidayatullah G. Munshi, Maria Matsangou, Kazumi Ebine, Meng Shang, Samad Z. Munshi, Brian DeCant, Thao Pham, Krishan Kumar

Publikováno v: Molecular Cancer Therapeutics. 18:235-244

BET inhibitors (BETi), which target transcription of key oncogenic genes, are currently being evaluated in early-phase clinical trials. However, because BETis show limited single-agent activity, there is increasing interest in identifying signaling p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417805f853e9c11b593f95c97be2fbc2
https://doi.org/10.1158/1535-7163.mct-18-0768

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