Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kazumi, Hagiwara"'
Publikováno v:
Anticancer research. 39(7)
Background/aim Neuroblastoma (NB) is the most common extracranial solid tumor in childhood; treatments with greater effectiveness are required for NB, especially in advanced cases. This study aimed at evaluating the combined effect of anaplastic lymp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b215f29cf78789f99a55972f1adb11
https://pubmed.ncbi.nlm.nih.gov/31262882
https://pubmed.ncbi.nlm.nih.gov/31262882
Autor:
Hirokazu Nagai, Kazumi Hagiwara, Yasuhiko Miyata, Tomoki Naoe, Shinji Kunishima, Hiroatsu Iida
Publikováno v:
Apoptosis. 20:975-985
Mantle cell lymphoma (MCL) is a B cell malignancy characterized by aberrant expression of cyclin D1 due to a t(11;14) translocation. MCL is refractory to conventional chemotherapy, and treatment remains challenging. We investigated the efficacy of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e518de2d4c5b4d3ba0de1456b721e01e
https://doi.org/10.1007/s10495-015-1125-1
https://doi.org/10.1007/s10495-015-1125-1
Autor:
Kazumi Hagiwara, Takashi Murate, Hiromi Ito, Hirokazu Nagai, Haruhiko Ohashi, Yasuhiko Miyata
Publikováno v:
Genes, Chromosomes and Cancer. 51:1024-1036
Prospero-related homeobox 1 (PROX1) is important for embryonic organ formation and differentiation, and changes in PROX1 activity were recently associated with cancer. To address the PROX1 roles in tumorigenesis, we established cells stably overexpre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39897be990e631a41cdc3fb1f7fe22ca
https://doi.org/10.1002/gcc.21985
https://doi.org/10.1002/gcc.21985
Publikováno v:
Blood. 132:5303-5303
Background: Mantle cell lymphoma (MCL) is a moderately aggressive lymphoma and its pathogenesis is not fully understood. The genetic hallmark of MCL is the chromosomal translocation t(11;14)(q13;q32), causing upregulation of cyclin D1. However, appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9003738d6a65c0f9d988a25a9fa4c4bb
https://doi.org/10.1182/blood-2018-99-118265
https://doi.org/10.1182/blood-2018-99-118265
Autor:
Hirokazu Nagai, Haruhiko Ohashi, Shinji Kunishma, Kazumi Hagiwara, Yinghua Li, Tomohiro Kinoshita, Tomomitsu Hotta
Publikováno v:
Leukemia Research. 34:50-54
The detection of minimal residual disease (MRD) in bone marrow is very important in the clinical management of malignant lymphoma. So far, the assessment of MRD in cases of diffuse large B cell lymphoma (DLBCL) has had some technical limitations, suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ede308a5429c9a5afeb6eeeeb77ef5
https://doi.org/10.1016/j.leukres.2009.06.028
https://doi.org/10.1016/j.leukres.2009.06.028
Autor:
Kotaro Shide, Takashi Murate, A Furuhata, Akihiro Abe, Kohsuke Yoshida, Kazumi Hagiwara, Y. Tagawa, Hiromi Ito, Masashi Murakami, Motoshi Suzuki, Tomoki Naoe, Akira Takagi, S Gao, Kazuya Shimoda, Tetsuhito Kojima, A. Kimura
Publikováno v:
Biochemical and Biophysical Research Communications. 383:411-416
Janus kinase 2 (JAK2) V617F mutation has been regarded as the major cause of myeloproliferative disorders (MPD). However, the mechanisms of abnormal cell growth by JAK2V617F have not been elucidated. In this study, cell cycle regulatory protein expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfd3a419bf352dc7cec966bd9879ce0
https://doi.org/10.1016/j.bbrc.2009.04.015
https://doi.org/10.1016/j.bbrc.2009.04.015
Autor:
Naoki, Mizutani, Hiromi, Ito, Kazumi, Hagiwara, Misa, Kobayashi, Asuka, Hoshikawa, Yayoi, Nishida, Akira, Takagi, Tetsuhito, Kojima, Motoshi, Suzuki, Yosuke, Osawa, Kazunori, Ohnishi, Masanori, Daibata, Takashi, Murate
Publikováno v:
Nagoya Journal of Medical Science
Cytokine-dependent cell lines have been used to analyze the cytokine-induced cellular signaling and the mechanism of oncogenesis. In the current study, we analyzed MOTN-1 and PLT-2 cell lines established from different stages of a T-cell large granul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ded623c724dddba13adb5fc57be0422
https://pubmed.ncbi.nlm.nih.gov/23092099
https://pubmed.ncbi.nlm.nih.gov/23092099
Autor:
Tetsuhito Kojima, Masatoshi Ichihara, Asuka Hoshikawa, Hiromi Ito, Kazumi Hagiwara, Akira Takagi, Naoki Mizutani, Misa Kobayashi, Yoshiko Banno, Takashi Murate, Keiko Tamiya-Koizumi, Yoshinori Nozawa, Kouji Tanaka, Motoshi Suzuki, Sayaka Sobue, Mitsuhiro Nakamura
Publikováno v:
Journal of biochemistry. 151(6)
Effects of all-trans retinoic acid (ATRA) on sphingomyelinase expression were examined using MCF-7 (ATRA-sensitive) and MDA-MB-231 (ATRA-resistant) breast cancer cells. Increased NSMase activity, NSMase2 mRNA and protein were observed in ATRA-treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6e2c8fec6134235662e34791dad49d
https://pubmed.ncbi.nlm.nih.gov/22496486
https://pubmed.ncbi.nlm.nih.gov/22496486
Autor:
Kouji Tanaka, Motoshi Suzuki, Mitsuhiro Nakamura, Mamoru Kyogashima, Tetsuhito Kojima, Satoshi Fujii, Yoshiko Banno, Takashi Murate, Keiko Tamiya-Koizumi, Tatsuya Tsurumi, Soichiro Iwaki, Hiromi Ito, Reiji Kannagi, Akira Takagi, Kazumi Hagiwara
Publikováno v:
Journal of biochemistry. 151(6)
Neutral ceramidase (NCDase) is considered to be a critical enzyme for controlling the turnover of ceramide, an important bioactive lipid, which determines cell's fate. All-trans retinoic acid (ATRA) has been reported to induce neuronal differentiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c179535ba6d0f1e7e6bd2ce5a7ed49
https://pubmed.ncbi.nlm.nih.gov/22451680
https://pubmed.ncbi.nlm.nih.gov/22451680
Autor:
Motoshi Suzuki, Kazumi Hagiwara, Yoshiko Banno, Takashi Murate, Asuka Hoshikawa, Keiko Tamiya-Koizumi, Masatoshi Ichihara, Sayaka Sobue, Tetsuhito Kojima, Hiromi Ito, Akira Takagi, Misa Kobayashi, Masashi Murakami, Yoshinori Nozawa
Publikováno v:
Journal of cellular biochemistry. 112(11)
Glial cell line-derived neurotrophic factor (GDNF) is important for the development and maintenance of dopamine neurons (Lin et al. [1993] Science 260: 1130–1132). GDNF is neuroprotective in animal models of Parkinson disease, where dopamine neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd4b43e3cfb2fb97b07d4ac54b6a390
https://pubmed.ncbi.nlm.nih.gov/21769916
https://pubmed.ncbi.nlm.nih.gov/21769916