Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kazumasa Takanashi"'
Autor:
Kenta Fujinuma, Takuji Harada, Yoshiki Uchida, Makoto Tamaki, Masahiro Kimura, Kazumasa Takanashi, Mitsuno Shindo
Publikováno v:
Chemical and Pharmaceutical Bulletin. 60:743-746
To find candidates with high antimicrobial and low hemolytic activities, many gratisin (GR) analogues have been designed and synthesized. In the present account, we synthesized novel derivatives of GR having both the polycationic and fatty acyl group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e4912a266d57c88dfbe243b56ad713
https://doi.org/10.1248/cpb.60.743
https://doi.org/10.1248/cpb.60.743
Autor:
Kenta Fujinuma, Mitsuno Shindo, Makoto Tamaki, Yoshiki Uchida, Takuji Harada, Masahiro Kimura, Kazumasa Takanashi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:106-109
In the present study, novel eight GS derivatives having the octanoyl-(Lys)n- moieties, cyclo{-Val-Orn-Leu- d -Phe-Pro(4β-NH-X)-Val-Orn-Leu- d -Phe-Pro-} {X = −H (1), and -(Lys)n-CO(CH2)6CH3 n = 0 (2), 1 (3), 2 (4), and 3 (5)} and cyclo{-Val-Orn-Le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873eb0a270f4364f5002b0b0d53da757
https://doi.org/10.1016/j.bmcl.2011.11.062
https://doi.org/10.1016/j.bmcl.2011.11.062
Autor:
Masahiro Kimura, Kazumasa Takanashi, Yoshiki Uchida, Makoto Tamaki, Kenta Fujinuma, Takuji Harada, Mitsuno Shindo
Publikováno v:
Chemical and Pharmaceutical Bulletin. 60:1134-1138
The substitution of each constituent amino acid residue of gramicidin S (GS), cyclo(-Val(1,1')-Orn(2,2')-Leu(3,3')-D-Phe(4,4')-Pro(5,5')-)(2) with Lys residue indicated that each side chain structure of the constituent amino acid residues affect larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90e8be30b042b3ce63e4e0446496d75
https://doi.org/10.1248/cpb.c12-00290
https://doi.org/10.1248/cpb.c12-00290
Autor:
Takuji Harada, Yoshiki Uchida, Kenta Fujinuma, Mitsuno Shindo, Makoto Tamaki, Masahiro Kimura, Kazumasa Takanashi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 59:1481-1484
To find candidates with high antimicrobial and low hemolytic activities, many gramicidin S (GS) analogs of various ring sizes have been designed and synthesized. However, syntheses of antimicrobially active analogues of GS having a disordered symmetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cc2cdb3fef48ff44d0f43b12ee2fe6
https://doi.org/10.1248/cpb.59.1481
https://doi.org/10.1248/cpb.59.1481