Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kazumasa Miyamoto"'
Autor:
Hiroaki Nagai, Tomoko Satomi, Akiko Abiru, Kazumasa Miyamoto, Koji Nagasawa, Minoru Maruyama, Satoshi Yamamoto, Kuniko Kikuchi, Hiromitsu Fuse, Masakuni Noda, Yoshiyuki Tsujihata
Publikováno v:
EBioMedicine, Vol 24, Iss C, Pp 147-158 (2017)
Since impaired mitochondrial ATP production in cardiomyocytes is thought to lead to heart failure, a drug that protects mitochondria and improves ATP production under disease conditions would be an attractive treatment option. In this study, we ident
Externí odkaz:
https://doaj.org/article/5da0bd74b32a4b12af463c18fb53afa0
Autor:
Akiko Oki, Katsunori Sasa, Hiroyuki Takada, Bunnai Saito, Kazumasa Miyamoto, Tomoko Nagino, Hidetoshi Sakurai, Ryuichi Tozawa, Tatsuo Oikawa, Makoto Miyamoto, Yuko Kokubu, Michiko Tawada, Tomoya Sameshima, Akira Kaieda
Publikováno v:
Journal of Medicinal Chemistry. 62:9175-9187
Dysferlinopathies, which are muscular diseases caused by mutations in the dysferlin gene, remain serious medical problems due to the lack of therapeutic agents. Herein, we report the design, synthesis, and structure-activity relationships of a 2,6-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9111b391e088e8dd74adcaa24e72217
https://doi.org/10.1021/acs.jmedchem.9b01100
https://doi.org/10.1021/acs.jmedchem.9b01100
Autor:
Toshiyuki Takeuchi, Tadahiro Nambu, Jessica Huck Sappal, Kazumasa Miyamoto, Akifumi Kogame, Kurt Eng, Yukie Kashima, Kazuyo Kakoi, Shun-Ichiro Kageyama, Karuppiah Kannan, Hiroshi Haeno, Saomi Murai, Akihiro Ohashi, Jie Yu, Masamitsu Gotou, Osamu Kurasawa, Huifeng Niu, Kenichi Iwai
Publikováno v:
Science Advances
Potential combination partners of a CDC7 inhibitor TAK-931 were identified to guide its clinical development strategy.
Cell division cycle 7 (CDC7), a serine/threonine kinase, plays important roles in DNA replication. We developed a highly speci
Cell division cycle 7 (CDC7), a serine/threonine kinase, plays important roles in DNA replication. We developed a highly speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5236f1b80216656eb0994e1e5f1ab2ba
http://europepmc.org/articles/PMC8139593
http://europepmc.org/articles/PMC8139593
Autor:
Yoshika Hayakawa-Yano, Masahiro Nogami, Atsushi Nakanishi, Kazumasa Miyamoto, Hideyuki Okano, Masato Yano
Publikováno v:
The Journal of Biological Chemistry
Microprocessor complex, including DiGeorge syndrome critical region gene 8 (DGCR8) and DROSHA, recognizes and cleaves primary transcripts of microRNAs (pri-miRNAs) in the maturation of canonical miRNAs. The study of DGCR8 haploinsufficiency reveals t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d99c1c44e3c4d93bf7abe2ccedf613e
https://pubmed.ncbi.nlm.nih.gov/33581109
https://pubmed.ncbi.nlm.nih.gov/33581109
Autor:
Yoshiyuki Tsujihata, Tomoko Satomi, Satoshi Yamamoto, Kazumasa Miyamoto, Hiromitsu Fuse, Akiko Abiru, Hiroaki Nagai, Masakuni Noda, Koji Nagasawa, Minoru Maruyama, Kuniko Kikuchi
Publikováno v:
EBioMedicine, Vol 24, Iss C, Pp 147-158 (2017)
EBioMedicine
EBioMedicine
Since impaired mitochondrial ATP production in cardiomyocytes is thought to lead to heart failure, a drug that protects mitochondria and improves ATP production under disease conditions would be an attractive treatment option. In this study, we ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9f78ce5cb5809ee38c68f0d53f5bba
http://www.sciencedirect.com/science/article/pii/S2352396417303766
http://www.sciencedirect.com/science/article/pii/S2352396417303766
Autor:
Takahito Hara, Satoshi Kitazawa, Misa Iwatani, Hitoshi Miyashita, Ryutaro Adachi, Yukiko Yamamoto, Megumi Morimoto, Takeo Arita, Sou Sakamoto, Takaharu Hirayama, Kazumasa Miyamoto
Publikováno v:
Biochemical and Biophysical Research Communications. 488:648-654
Protein translation is highly activated in cancer tissues through oncogenic mutations and amplifications, and this can support survival and aberrant proliferation. Therefore, blocking translation could be a promising way to block cancer progression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda348abfaf1262d6c6f1c6c91988b09
https://doi.org/10.1016/j.bbrc.2017.01.045
https://doi.org/10.1016/j.bbrc.2017.01.045
Autor:
Kosuke Harada, Hiroshi Kohara, Yoshiko Okai, Matthew Wagoner, Akimitsu Miyawaki, Toshikatsu Matsui, Kazumasa Miyamoto, Kazunori Yamanaka, Piyush Bajaj, Tadahiro Shinozawa
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 173(2)
Cholestasis resulting from hepatic bile acid efflux transporter inhibition may contribute to drug-induced liver injury (DILI). This condition is a common safety-related reason for drug attrition and withdrawal. To screen for safety risks associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d938bd044b68944052e0504984ba02
https://pubmed.ncbi.nlm.nih.gov/31722436
https://pubmed.ncbi.nlm.nih.gov/31722436
Autor:
Hiroyuki, Takada, Akira, Kaieda, Michiko, Tawada, Tomoko, Nagino, Katsunori, Sasa, Tatsuo, Oikawa, Akiko, Oki, Tomoya, Sameshima, Kazumasa, Miyamoto, Makoto, Miyamoto, Yuko, Kokubu, Ryuichi, Tozawa, Hidetoshi, Sakurai, Bunnai, Saito
Publikováno v:
Journal of medicinal chemistry. 62(20)
Dysferlinopathies, which are muscular diseases caused by mutations in the dysferlin gene, remain serious medical problems due to the lack of therapeutic agents. Herein, we report the design, synthesis, and structure-activity relationships of a 2,6-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd17d6870974e86fdd2fb0361e89ead6
https://pubmed.ncbi.nlm.nih.gov/31550153
https://pubmed.ncbi.nlm.nih.gov/31550153
Autor:
Kazunori Yamanaka, Tadahiro Shinozawa, Emily Pfeiffer Kaushik, Kazumasa Miyamoto, Toshikatsu Matsui, Kousuke Harada, Yoshiko Okai, Matthew Wagoner
Publikováno v:
Toxicology and applied pharmacology. 383
Recent developments of novel targeted therapies are contributing to the increased long-term survival of cancer patients; however, drug-induced cardiotoxicity induced by cancer drugs remains a serious problem in clinical settings. Nevertheless, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d33bb4b68bc93807aa81e6ea721f57
https://pubmed.ncbi.nlm.nih.gov/31533062
https://pubmed.ncbi.nlm.nih.gov/31533062
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