Výsledky vyhledávání - "Kazumasa Kuki"

Z-360 Suppresses Tumor Growth in MIA PaCa-2-bearing Mice via Inhibition of Gastrin-induced Anti-Apoptotic Effects

Autor: Yuko Hori, Yoshihiro Shiomi, Kazumasa Kuki, Makoto Yoshimura, Takao Tanaka

Publikováno v: Anticancer Research. 37

Background/aim The aim of the study was to evaluate the anti-tumor mechanism of Z-360, a gastrin/cholecystokinin-2 receptor (CCK2R) antagonist, in MIA PaCa-2 cells and in a subcutaneous xenograft mice model. Materials and methods The anti-tumor effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32291bd1b06869a73887beb0b9719f7c
https://doi.org/10.21873/anticanres.11800

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Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP)

Autor: Naoto Yamaguchi, Shuto Iwasawa, Ryuzaburo Yuki, Noritaka Yamaguchi, Yuuki Hashimoto, Takeshi Tomonaga, Yuki Takakura, Kazumasa Aoyama, Kazumasa Kuki, Yuji Nakayama, Takahisa Kuga

Publikováno v: Biochemical and biophysical research communications. 490(3)

c-Abl is a non-receptor-type tyrosine kinase that plays an important role in cell proliferation, migration, apoptosis, and fibrosis. Furthermore, although c-Abl is involved in transforming growth factor-β (TGF-β) signaling, its molecular functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc892bfa206080b735543c98fb7e870
https://pubmed.ncbi.nlm.nih.gov/28666867

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Z-360 Suppresses Tumor Growth in MIA PaCa-2-bearing Mice

Autor: Yoshihiro, Shiomi, Makoto, Yoshimura, Kazumasa, Kuki, Yuko, Hori, Takao, Tanaka

Publikováno v: Anticancer research. 37(8)

The aim of the study was to evaluate the anti-tumor mechanism of Z-360, a gastrin/cholecystokinin-2 receptor (CCK2R) antagonist, in MIA PaCa-2 cells and in a subcutaneous xenograft mice model.The anti-tumor effects of Z-360 and/or gemcitabine were mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa8fa450809a3ff7d35f9cd6728a5479
https://pubmed.ncbi.nlm.nih.gov/28739697

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Lyn tyrosine kinase promotes silencing of ATM-dependent checkpoint signaling during recovery from DNA double-strand breaks

Autor: Yasunori Fukumoto, Yudai Ide, Yuji Nakayama, Naoto Yamaguchi, Takuya Honda, Sho Kubota, Noritaka Yamaguchi, Takahito Miura, Hitomi Hasegawa, Mariko Morii, Kazumasa Kuki, Kenichi Ishibashi

Publikováno v: Biochemical and biophysical research communications. 452(3)

DNA damage activates the DNA damage checkpoint and the DNA repair machinery. After initial activation of DNA damage responses, cells recover to their original states through completion of DNA repair and termination of checkpoint signaling. Currently,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa9e1cdf821484f651b9c9a6a37a03b
https://pubmed.ncbi.nlm.nih.gov/25173936

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