Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Kazumasa Hirata"'
Autor:
Sayaka Deguchi, Tomohiro Shintani, Kazuo Harada, Toru Okamoto, Akinori Takemura, Kazumasa Hirata, Kousei Ito, Kazuo Takayama, Hiroyuki Mizuguchi
Publikováno v:
Hepatology Communications, Vol 5, Iss 8, Pp 1385-1399 (2021)
In drug development, a system for predicting drug metabolism and drug‐induced toxicity is necessary to ensure drug safety. Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) is an important drug‐metabolizing enzyme expressed in the liver and
Externí odkaz:
https://doaj.org/article/0dcd03a6c47942ae95c34c3c10e76bf5
Autor:
Hong Tao, Kazuya Nagano, Ikkei Tasaki, Tian-qi Zhang, Takuya Ishizaka, Jian-Qing Gao, Kazuo Harada, Kazumasa Hirata, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi
Publikováno v:
Nanoscale Research Letters, Vol 15, Iss 1, Pp 1-8 (2020)
Abstract In order to ensure the safe usage of silver nanoparticles (nAgs) in cosmetics, it is necessary to reveal the physical properties of nAgs inside the skin, as these properties may change during the process of percutaneous absorption. In this s
Externí odkaz:
https://doaj.org/article/5cf0b55a720b4e9f80b22585d40081dc
Autor:
Kanae Kawai, Ryosuke Negoro, Moe Ichikawa, Tomoki Yamashita, Sayaka Deguchi, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 49-57 (2020)
Because many peptide and peptide-mimetic drugs are substrates of peptide transporter 1, it is important to evaluate the peptide transporter 1-mediated intestinal absorption of drug candidates in the early phase of drug development. Although intestina
Externí odkaz:
https://doaj.org/article/c8a8b4e79ebc465381c1877f9ec90e31
Autor:
Takuya Ishizaka, Kazuya Nagano, Ikkei Tasaki, Hong Tao, Jian-Qing Gao, Kazuo Harada, Kazumasa Hirata, Shigeru Saito, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi
Publikováno v:
Nanoscale Research Letters, Vol 14, Iss 1, Pp 1-7 (2019)
Abstract The prevalent use of engineered nanoparticles (ENPs) has increased our exposure to these particles. The current available analytical techniques fail to simultaneously quantify and analyze the physical properties of ENPs in biological tissues
Externí odkaz:
https://doaj.org/article/ff91538a39bb406797979d7ccfd1e426
Autor:
Kazuo Takayama, Ryosuke Negoro, Tomoki Yamashita, Kanae Kawai, Moe Ichikawa, Takanori Mori, Noriyuki Nakatsu, Kazuo Harada, Sumito Ito, Hiroshi Yamada, Yoshiyuki Yamaura, Kazumasa Hirata, Seiichi Ishida, Hiroyuki Mizuguchi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 3, Pp 513-526 (2019)
Background & aims: To develop an effective and safe orally administered drug, it is important to predict its intestinal absorption rate, intestinal first-pass effect, and drug-drug interactions of orally administered drugs. However, there is no exist
Externí odkaz:
https://doaj.org/article/a5350c356a974b62a90fa723f7affb0a
Autor:
Kayoko Takeda Mamiya, Kazumasa Hirata
Publikováno v:
Pharmacy, Vol 10, Iss 3, p 64 (2022)
Objective: To understand how physicians and nurses evaluate Japanese pharmacists’ observed competencies and to explore potential new roles for pharmacists during COVID-19. Methods: A web-based Japanese survey with 25 items assessing physicians’ a
Externí odkaz:
https://doaj.org/article/26f85977a58649e9be75f6e66597a763
Autor:
Ryosuke Negoro, Kazuo Takayama, Kanae Kawai, Kazuo Harada, Fuminori Sakurai, Kazumasa Hirata, Hiroyuki Mizuguchi
Publikováno v:
Stem Cell Reports, Vol 11, Iss 6, Pp 1539-1550 (2018)
Summary: The small intestine plays an important role in the absorption and metabolism of oral drugs. In the current evaluation system, it is difficult to predict the precise absorption and metabolism of oral drugs. In this study, we generated small i
Externí odkaz:
https://doaj.org/article/a4509f970ad84331869bf201f2a2620d
Autor:
Yukiko Toba, Sayaka Deguchi, Natsumi Mimura, Ayaka Sakamoto, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229654 (2020)
Human hepatocytes are essential materials in pharmaceutical researches. Not only primary human hepatocytes (PHH) but also human iPS cell-derived hepatocyte-like cells (human iPS-HLCs) are expected to be applied as materials for pharmaceutical researc
Externí odkaz:
https://doaj.org/article/5240fcba42ce4e8184e95ee95e5b9f01
Autor:
Yuko Ueda, Kaori Kitae, Ikumi Ooshio, Yasuyuki Fusamae, Megumi Kawaguchi, Kentaro Jingushi, Kazuo Harada, Kazumasa Hirata, Kazutake Tsujikawa
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 476-481 (2016)
Human AlkB homolog 3 (ALKBH3), a homolog of the Escherichia coli protein AlkB, demethylates 1-methyladenine and 3-methylcytosine (3-meC) in single-stranded DNA and RNA by oxidative demethylation. Immunohistochemical analyses on clinical cancer specim
Externí odkaz:
https://doaj.org/article/cbee922f11e44b89961880de0d5217e2
Reactivity of γ‐glutamyl‐cysteine with intracellular and extracellular glutathione metabolic enzymes
Autor:
Misa Muraoka, Saki Yoshida, Moeka Ohno, Hideyuki Matsuura, Kazuya Nagano, Yoshihiko Hirata, Masayoshi Arai, Kazumasa Hirata
Publikováno v:
FEBS Letters. 596:180-188
Gamma-glutamyl-cysteine (γ-EC) is a precursor of glutathione (GSH) biosynthesis. We investigated whether it functions as a substrate for three intracellular and one extracellular GSH metabolic enzymes, which mediate the antioxidant defence function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b533fe1fda006ce193323112c927c63
https://doi.org/10.1002/1873-3468.14261
https://doi.org/10.1002/1873-3468.14261