Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kazuma Shimanaka"'
Autor:
Nagendran Ramalingam, Shan-Xue Jin, Tim E. Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P. Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David Sulzer, Eugene V. Mosharov, Weisheng V. Chen, Shaomin Li, Dennis J. Selkoe, Ulf Dettmer
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract In Parkinson’s disease and other synucleinopathies, the elevation of α-synuclein phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the physiological role for pS129 has remained undefined. Here we use mult
Externí odkaz:
https://doaj.org/article/d183b6fc70b54d8f9e89896f83034181
Autor:
Eduardo Ramirez, Sehong Min, Susantha K. Ganegamage, Kazuma Shimanaka, Magaly Guzman Sosa, Ulf Dettmer, Jean-Christophe Rochet, Jessica S. Fortin
Publikováno v:
Results in Chemistry, Vol 5, Iss , Pp 100938- (2023)
Alzheimer’s disease (AD) is a multifactorial, chronic neurodegenerative disease characterized by the presence of extracellular β-amyloid (Aβ) plaques, intraneuronal neurofibrillary tangles (NFTs), activated microglial cells, and an inflammatory s
Externí odkaz:
https://doaj.org/article/d6777e6966384829a372fdced7a39554
Autor:
Eduardo Ramirez, Susantha K. Ganegamage, Ahmed A. Elbatrawy, Heba Alnakhala, Kazuma Shimanaka, Arati Tripathi, Sehong Min, Jean-Christophe Rochet, Ulf Dettmer, Jessica S. Fortin
Publikováno v:
ACS Omega.
Autor:
Jessica S, Fortin, Kazuma, Shimanaka, A Prasanth, Saraswati, Mengyu, Liu, Kuang-Wei, Wang, Hsiao-Tien, Hagar, Soham, Maity, Susantha K, Ganegamage, Edmund, Ellsworth, Scott E, Counts, Babak, Borhan, Ulf, Dettmer, Min-Hao, Kuo
Publikováno v:
J Mol Struct
In contrast to Aβ plaques, the spatiotemporal distribution of neurofibrillary tangles of hyperphosphorylated tau (p-tau) predicts cognitive impairment in Alzheimer’s disease (AD), underscoring the key pathological role of p-tau and the utmost need
Autor:
Silke Nuber, Chee Yeun Chung, Daniel F. Tardiff, Pascal A. Bechade, Thomas D. McCaffery, Kazuma Shimanaka, Jeonghoon Choi, Belle Chang, Waseem Raja, Esther Neves, Christopher Burke, Xin Jiang, Ping Xu, Vikram Khurana, Ulf Dettmer, Saranna Fanning, Kenneth J. Rhodes, Dennis J. Selkoe, Robert H. Scannevin
Publikováno v:
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 19(3)
Increasing evidence has shown that Parkinson’s disease (PD) impairs midbrain dopaminergic, cortical and other neuronal subtypes in large part due to the build-up of lipid- and vesicle-rich α-synuclein (αSyn) cytotoxic inclusions. We previously id
Autor:
Nurhanis B.M. Isa, Rachel S. Kepczynski, Soham Maity, Kazuma Shimanaka, Babak Borhan, Ulf Dettmer, Jessica S. Fortin, Anisa M. Rashid, Laken N. Rivet, Malikah O’Dell
Publikováno v:
Journal of Molecular Structure. 1249:131569
Amyloidosis, a group of diseases caused by the fibrillation of prone-to-aggregate proteins, remains one of the most difficult ailments to treat human medicine. This study focuses on the amyloid protein, alpha-synuclein (α-syn), the major pathogeneti