Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Kazuma Murakami"'
Autor:
Yayoi Obata, Kazuma Murakami, Taiji Kawase, Kenji Hirose, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie
Publikováno v:
ACS Omega, Vol 5, Iss 34, Pp 21531-21537 (2020)
Externí odkaz:
https://doaj.org/article/fb417b04a9af4aa3b1597a9b183e48de
Autor:
Kento Tsukada, Shono Shinki, Akiho Kaneko, Kazuma Murakami, Kazuhiro Irie, Masatoshi Murai, Hideto Miyoshi, Shingo Dan, Kumi Kawaji, Hironori Hayashi, Eiichi N. Kodama, Aki Hori, Emil Salim, Takayuki Kuraishi, Naoya Hirata, Yasunari Kanda, Teigo Asai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Combining genome mining and heterologous expression in a genetically tractable host can lead to bioactive natural products discovery and production. Here, the authors employ this strategy for new decalin-containing diterpenoid pyrenes production by e
Externí odkaz:
https://doaj.org/article/b8d5d9bdb0c848689511d663ed7160bb
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 8 (2021)
AbstractThe regulation of sleep and metabolism are highly interconnected, and dysregulation of sleep is linked to metabolic diseases that include obesity, diabetes, and heart disease. Furthermore, both acute and long-term changes in diet potently imp
Externí odkaz:
https://doaj.org/article/5da793e703ca43418d77d69e5b49eb51
Autor:
Tomohiro Imamura, Yuki T. Yanagihara, Yasumasa Ohyagi, Norimichi Nakamura, Kyoko M. Iinuma, Ryo Yamasaki, Hirohide Asai, Masahiro Maeda, Kazuma Murakami, Kazuhiro Irie, Jun-ichi Kira
Publikováno v:
Neurobiology of Disease, Vol 137, Iss , Pp 104739- (2020)
The toxic conformer of amyloid β-protein (Aβ) ending at 42 (Aβ42), which contains a unique turn conformation at amino acid residue positions 22 and 23 and tends to form oligomers that are neurotoxic, was reported to play a critical role in the pat
Externí odkaz:
https://doaj.org/article/d659524132464ccb9ae523698c39be69
Autor:
Abdelbasset Boubakri, Manuela Leri, Monica Bucciantini, Hanen Najjaa, Abdelkarim Ben Arfa, Massimo Stefani, Mohamed Neffati, Kazuma Murakami
Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
Allium roseum is an important medicinal and aromatic plant, specific to the North African flora and a rich source of important nutrients and bioactive molecules including flavonoids and organosulfur compounds whose biological activities and pharmacol
Externí odkaz:
https://doaj.org/article/f8efedac9e9f4b4b8deec671e1088e44
Autor:
Kazuma Murakami, Mayuko Yoshimura, Shota Nakagawa, Toshiaki Kume, Takayuki Kondo, Haruhisa Inoue, Kazuhiro Irie
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1179 (2020)
Amyloid β42 (Aβ42), a causative agent of Alzheimer’s disease (AD), is derived extracellularly from Aβ precursor protein (APP) following the latter’s cleavage by β-secretase, but not α-secretase. Protein kinase Cα (PKCα) activation is known
Externí odkaz:
https://doaj.org/article/8e4e9a95fe054903bf89a949a03070dd
Autor:
Kazuma Murakami, Kazuhiro Irie
Publikováno v:
Molecules, Vol 24, Iss 11, p 2125 (2019)
Aggregation of amyloid β42 (Aβ42) is one of the hallmarks of Alzheimer’s disease (AD). There are numerous naturally occurring products that suppress the aggregation of Aβ42, but the underlying mechanisms remain to be elucidated. Based on NMR and
Externí odkaz:
https://doaj.org/article/33658d823b3640799b438568702117b2
Publikováno v:
Applied Environmental Research, Vol 36, Iss 4 (2014)
This paper analyzes the determinants of environmental management transfer and environmental performance by Japanese firms in Thailand. For sustainable development, all actors need to contribute to the reduction of environmental loads. This requiremen
Externí odkaz:
https://doaj.org/article/761ef3c350a74673afaf861c5516cf05
Autor:
Takayuki Suzuki, Kazuma Murakami, Naotaka Izuo, Toshiaki Kume, Akinori Akaike, Tetsu Nagata, Tomoyuki Nishizaki, Takami Tomiyama, Hiroshi Takuma, Hiroshi Mori, Kazuhiro Irie
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Oligomers of 40- or 42-mer amyloid β-protein (Aβ40, Aβ42) cause cognitive decline and synaptic dysfunction in Alzheimer's disease. We proposed the importance of a turn at Glu22 and Asp23 of Aβ42 to induce its neurotoxicity through the formation o
Externí odkaz:
https://doaj.org/article/7c5c3dd3112142f4b7b68ee4098cb8b4
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7694 (2009)
Aptamers are useful molecular recognition tools in research, diagnostics, and therapy. Despite promising results in other fields, aptamer use has remained scarce in amyloid research, including Alzheimer's disease (AD). AD is a progressive neurodegene
Externí odkaz:
https://doaj.org/article/98895b06cc254aaca5635bab2e087968