Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kazuko Takahashi-Niki"'
Autor:
Kazuko Takahashi-Niki, Ayako Inafune, Naruyuki Michitani, Yoshitaka Hatakeyama, Kotaro Suzuki, Mai Sasaki, Yoshihisa Kitamura, Takeshi Niki, Sanae M.M. Iguchi-Ariga, Hiroyoshi Ariga
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 305-310 (2015)
Parkinson's disease (PD) is caused by dopaminergic cell death in the substantia nigra, leading to a reduced level of dopamine in the striatum. Oxidative stress is one of the causes of PD. Since symptomatic PD therapies are used, identification of com
Externí odkaz:
https://doaj.org/article/1476a834b4384783a409ac145982a2ad
Autor:
Takuya Yamane, Sayaka Suzui, Hirotake Kitaura, Kazuko Takahashi-Niki, Sanae M M Iguchi-Ariga, Hiroyoshi Ariga
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78374 (2013)
DJ-1 is an oncogene and also causative gene for familial Parkinson's disease. DJ-1 has multiple functions, including transcriptional regulation. DJ-1 acts as a coactivator that binds to various transcription factors, resulting in stimulation or repre
Externí odkaz:
https://doaj.org/article/f67b25cfebc544b29b5fda13e19ca598
Autor:
Shiori Yamaguchi, Takuya Yamane, Kazuko Takahashi-Niki, Izumi Kato, Takeshi Niki, Matthew S Goldberg, Jie Shen, Kenji Ishimoto, Takefumi Doi, Sanae M M Iguchi-Ariga, Hiroyoshi Ariga
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38144 (2012)
DJ-1 is a novel oncogene and also causative gene for familial Parkinson's disease park7. DJ-1 has multiple functions that include transcriptional regulation, anti-oxidative reaction and chaperone and mitochondrial regulation. For transcriptional regu
Externí odkaz:
https://doaj.org/article/85540d3ab11747a0bc6b1f3164b38c29
Autor:
Tatsuki Yasuda, Takeshi Niki, Sanae M.M. Iguchi-Ariga, Hiroyoshi Ariga, Yoshiro Saito, Asami Okamoto, Kazuko Takahashi-Niki, Jinro Endo
Publikováno v:
Brain Research. 1729:146641
DJ-1 was identified as an oncogene and also as a causative gene for a familial form of Parkinson disease (PD). DJ-1 plays various roles in anti-oxidative stress response. Superfluous oxidation of DJ-1 at cysteine residue 106 (C106), an inactive form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520940f2b894e64c6763aa687ac4260e
https://doi.org/10.1016/j.brainres.2019.146641
https://doi.org/10.1016/j.brainres.2019.146641
Autor:
Kotaro Suzuki, Naruyuki Michitani, Mai Sasaki, Kazuko Takahashi-Niki, Sanae M.M. Iguchi-Ariga, Ayako Inafune, Hiroyoshi Ariga, Yoshitaka Hatakeyama, Takeshi Niki, Yoshihisa Kitamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 305-310 (2015)
Parkinson's disease (PD) is caused by dopaminergic cell death in the substantia nigra, leading to a reduced level of dopamine in the striatum. Oxidative stress is one of the causes of PD. Since symptomatic PD therapies are used, identification of com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf7c5f18acabddb4870b3c15acebe20
Publikováno v:
Advances in experimental medicine and biology. 1037
DJ-1 is an oncogene and also a causative gene for familial Parkinson's disease. DJ-1 has various functions, and the oxidative status of a cysteine residue at position 106 (C106) is crucial for determination of the activation level of DJ-1.DJ-1 binds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2be5d0d17bc8a972ab2f3413727709e2
https://pubmed.ncbi.nlm.nih.gov/29147905
https://pubmed.ncbi.nlm.nih.gov/29147905
Autor:
Yasuo Ihara, Takao Hamakubo, Etsuo Niki, Noriko Noguchi, Tomohiro Miyasaka, Yasukazu Yoshida, Yoshiro Saito, Hiroyuki Hatsuta, Shigeo Murayama, Osamu Kusano-Arai, Hiroyoshi Ariga, Hiroko Iwanari, Kazuko Takahashi-Niki, Kojiro Hayashi, Yuichiro Mita
Publikováno v:
Journal of Neuropathology and Experimental Neurology
ResearcherID
ResearcherID
Supplemental digital content is available in the text.
DJ-1, the product of a causative gene of a familial form of Parkinson disease, undergoes preferential oxidation of Cys106 (cysteine residue at position 106) under oxidative stress. Using spe
DJ-1, the product of a causative gene of a familial form of Parkinson disease, undergoes preferential oxidation of Cys106 (cysteine residue at position 106) under oxidative stress. Using spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d93ad756d6f5445ea1b408cda3330c3
https://doi.org/10.1097/nen.0000000000000087
https://doi.org/10.1097/nen.0000000000000087
Autor:
Yuka Takekoshi, Takashi Shimizu, Akira Abe, Kazuko Takahashi-Niki, Hiroshi Maita, Hirotake Kitaura, Sanae M.M. Iguchi-Ariga, Hiroyoshi Ariga
Publikováno v:
Journal of Biological Chemistry. 288:27764-27776
Prefoldin is a molecular chaperone composed of six subunits, PFD1–6, and prevents misfolding of newly synthesized nascent polypeptides. Although it is predicted that prefoldin, like other chaperones, modulates protein aggregation, the precise funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3019d2983b33fd0b33e7cbc61b001d5b
https://doi.org/10.1074/jbc.m113.476358
https://doi.org/10.1074/jbc.m113.476358
Autor:
Masahiko Tsunemi, Kumiko Yoshizawa-Kumagaye, Hiroyoshi Ariga, Takeshi Niki, Sanae M.M. Iguchi-Ariga, Kazuko Takahashi-Niki, Hitomi Mitsugi, Kyoko Tanimura
Publikováno v:
FEBS Letters. 587:2493-2499
DJ-1, the product of familial Parkinson's disease gene and an oncogene, is a cysteine protease which plays a role in anti-oxidative stress reaction. In this study, we identified the recognition sequence for DJ-1 protease by using recombinant DJ-1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49de5652f65acdac0062afdf8496c43f
https://doi.org/10.1016/j.febslet.2013.06.032
https://doi.org/10.1016/j.febslet.2013.06.032
Autor:
Takeshi Niki, Hiroshi Maita, Hiroyoshi Ariga, Kazuko Takahashi-Niki, Sanae M.M. Iguchi-Ariga, Izumi Kato
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2013 (2013)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Parkinson’s disease (PD) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum. Oxidative stress and mitochondrial dysfunction are thought to be major causes of neurodegeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7b0d450344b3ab71355afd8696a6c7
https://doi.org/10.1155/2013/683920
https://doi.org/10.1155/2013/683920