Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kazuko Shimazaki"'
Autor:
Kinya Katayama, Kensuke Nabeta, Yasuhiro Hasa, Hiroyuki Koshino, Hiroyuki Tazaki, Kazuko Shimazaki, Masako Miyoshi, Tatsuo Furuki
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 71:2751-2758
New clerodane-type diterpenes, designated as parvitexins A (1)-E (5), were isolated from the in vitro-cultured liverwort, Scapania parvitexta. These compounds were determined to be monoacetylated clerodane-type diterpenes based on spectroscopic evide
Autor:
Sergey N. Ruzheinikov, Naoki Yamamoto, Hiroyuki Kakinuma, Yoshisuke Nishi, Sun Jialin, Tatyana A. Muranova, David W. Rice, Yasuhiro Kajihara, Kazuko Shimazaki, Naoko Takahashi-Ando
Publikováno v:
Journal of Biochemistry. 142:421-433
The esterolytic catalytic antibody (catAb) has the positive charged region interacting with the carbonyl group of the ester substrate. To examine how such a region interacts with the substrate, we compared the catAb with the non-catalytic antibody (n
Publikováno v:
The Journal of Biochemistry. 140:509-515
We performed a series of site-directed mutagenesis experiments of catalytic antibody, 6D9, which hydrolyzes a prodrug of chloramphenicol, based on our previous directed evolution study [Takahashi et al. (2001) Nat. Biotechnol. 19, 563-567]. Since we
Publikováno v:
Journal of Molecular Structure. 749:169-176
The conformational and electronic properties of the odor compounds, pyrazine and its derivatives, were investigated by molecular mechanics (MM3) and ab initio molecular orbital calculations in order to evaluate an odor activity. The calculated result
Autor:
Jilian Sun, Iain A. Murray, Lynda J. Partridge, Svetlana E. Sedelnikova, Naoko Takahashi-Ando, Hiroyuki Kakinuma, Sergey N. Ruzheinikov, David W. Rice, Tatyana A. Muranova, Kazuko Shimazaki, Yoshisuke Nishi, G. Michael Blackburn
Publikováno v:
Journal of Molecular Biology. 332:423-435
The crystal structures of four related Fab fragments of a family of catalytic antibodies displaying differential levels of esterase activity have been solved in the presence and in the absence of the transition-state analogue (TSA) that was used to e
Publikováno v:
Journal of Molecular Structure. 556:283-291
Phosphonamidate compounds are regarded as transition-state analogs for amide hydrolysis reactions and can be used as potent haptens to elicit catalytic antibodies. The MM3 force field has been extended to cover these compounds, based on the structure
Autor:
Kyoko Takahashi, Naoko Takahashi, Hiroyuki Kakinuma, Yoshisuke Nishi, Hajime Matsushita, Shigeo Niihata, Kazuhisa Sakakibara, Kazuko Shimazaki
Publikováno v:
Journal of Physical Organic Chemistry. 13:167-175
Autor:
Kyoko Takahashi, Hajime Matsushita, Kazuko Shimazaki, Yoshiko Aoki, Naoko Takahashi, Yoshisuke Nishi, Hiroyuki Kakinuma, Shigeo Niihata, Katsumi Hamada
Publikováno v:
Tetrahedron. 55:2559-2572
The relation between the structure of haptens and the esterolytic activities of antibodies was investigated. We synthesized two phenylalanine analogs, the negatively charged phosphonate derivative 1 and the neutral phosphonamidate derivative 2. Seven
Autor:
Keiichiro Ogawa, Takeshi Iwai, Yukio Kurita, Yasushi Yokoyama, Takakazu Goto, Kazuko Shimazaki, Yasuhiro Kajihara, Yayoi Yokoyama
Publikováno v:
Bulletin of the Chemical Society of Japan. 69:1605-1612
The conformations of the E-forms of photochromic furylfulgides with a methyl substituent (1E) and an isopropyl substituent (2E) were investigated by X-ray crystallographic analyses, NMR measurements, and molecular orbital (MO) calculations in relatio
Autor:
Jingzhu Ren, Takashi Nagata, Minoru Hirota, Tastuji Chuman, Hidetaka Kawamura, Kazuhisa Sakakibara, Kazuko Shimazaki
Publikováno v:
Bulletin of the Chemical Society of Japan. 67:2768-2778
The MM2 force field has been extended so as to deal with periplanone B and nitroxides by using empirical relationships which enable us to derive the MM2 stretching (ks) and bending force (kb) constants systematically. The stretching force constants (