Výsledky vyhledávání - "Kazuko Sagawa"

Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans

Autor: Li Di, Bo Feng, Jennifer Q. Dong, Kazuko Sagawa, Tim F. Ryder, Manthena V.S. Varma, Steven G. Terra, Amit S. Kalgutkar, Angela Wolford

Publikováno v: Drug Metabolism and Disposition. 44:209-219

The thiouracil derivative PF-06282999 [2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide] is an irreversible inactivator of myeloperoxidase and is currently in clinical trials for the potential treatment of cardio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfca1f808303a6721d41a7358f78ad02
https://doi.org/10.1124/dmd.115.067868

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The Effect of Excipients on the Permeability of BCS Class III Compounds and Implications for Biowaivers

Autor: Mario A. Gonzalez, Chris Bode, Wenlei Jiang, Kevin Miller, Ismael J. Hidalgo, Alan F. Parr, William Brown, Mehran Yazdanian, Kazuko Sagawa, Erika S. Stippler

Publikováno v: Pharmaceutical Research

Purpose Currently, the FDA allows biowaivers for Class I (high solubility and high permeability) and Class III (high solubility and low permeability) compounds of the Biopharmaceutics Classification System (BCS). Scientific evidence should be provide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02806414f084e57be188918af2b0abae
http://europepmc.org/articles/PMC4689772

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Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: In vitro and in vivo

Autor: Xiaodong Wang, Marilyn E. Morris, Elaine Tseng, Shuzhong Zhang, Kazuko Sagawa, Robert D. Arnold

Publikováno v: Journal of Pharmaceutical Sciences. 99:430-441

The purpose of this study was to investigate the in vitro and in vivo interactions between flavonoids and P-glycoprotein (P-gp) substrates. The inhibitory effects of flavonoids on P-gp were determined by accumulation studies in P-gp-overexpressing MC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9ae02a08682828d6115a3b694a9687
https://doi.org/10.1002/jps.21827

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Pharmacokinetics and bioavailability of the isoflavone biochanin A in rats

Autor: Kosea S. Frederick, Young Jin Moon, Shuzhong Zhang, Marilyn E. Morris, Kazuko Sagawa

Publikováno v: The AAPS Journal. 8:E433-E442

Biochanin A (BCA) is a dietary isoflavone present in legumes, most notably red clover, and in many herbal dietary supplements. BCA has been reported to have chemopreventive properties and is metabolized to the isoflavone genistein (GEN), BCA conjugat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e09adb8719310c30d064ca4eff3aa40
https://doi.org/10.1208/aapsj080351

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Activation of purified cardiac ryanodine receptors by dihydropyridine agonists

Autor: Kazuko Sagawa, J. Andrew Wasserstrom, Toshio Sagawa, Edward Kan, John Tsai, Andrew J. Lokuta, Manabu Nishio, James E. Kelly

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 280:H1201-H1207

Prior observations have raised the possibility that dihydropyridine (DHP) agonists directly affect the sarcoplasmic reticulum (SR) cardiac Ca2+release channel [i.e., ryanodine receptor (RyR)]. In single-channel recordings of purified canine cardiac R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9b19f78f21b674d1c0c80ec756eb3e
https://doi.org/10.1152/ajpheart.2001.280.3.h1201

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Molecular Mechanisms of Renal Sulfate Regulation

Autor: Kazuko Sagawa, Marilyn E. Morris

Publikováno v: Critical Reviews in Clinical Laboratory Sciences. 37:345-388

Inorganic sulfate is an important physiological anion that is a required cofactor for sulfate conjugation reactions of both endogenous and exogenous compounds. It is necessary for the detoxification of xenobiotics and endogenous compounds (catecholam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c909c1ebc45ec62ee9f460d8ae30eb7d
https://doi.org/10.1080/10408360091174240

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Effect of experimentally induced hypothyroidism on sulfate renal transport in rats

Autor: Kazuko Sagawa, Marilyn E. Morris, Heini Murer

Publikováno v: American Journal of Physiology-Renal Physiology. 276:F164-F171

Decreased serum sulfate concentrations are observed in hypothyroid patients. However, the mechanism involved in thyroid hormone-induced alterations of renal sulfate homeostasis is unknown. The objectives of this investigation were to determine the ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7134842db4703327769e4f5e278acbff
https://doi.org/10.1152/ajprenal.1999.276.1.f164

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