Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kazuko Asada"'
Autor:
Morio Ueno, MD, PhD, Kengo Yoshii, PhD, Tomoko Yamashita, PhD, Kazuhiro Sonomura, PhD, Kazuko Asada, BEng, Eiko Ito, BSci, Tomoko Fujita, BEd, Chie Sotozono, MD, PhD, Shigeru Kinoshita, MD, PhD, Junji Hamuro, PhD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 3, Pp 100299- (2023)
Purpose: The purpose of the study was to clarify the interplay between metabolites and microRNAs (miRs) in the aqueous humor (AqH) of bullous keratopathy (BK) patients to retain human corneal endothelium (HCE) integrity. Design: Prospective, comparat
Externí odkaz:
https://doaj.org/article/cabf9c0d46004751afc2079ae9d7e9ea
Autor:
Munetoyo Toda, Morio Ueno, Jun Yamada, Asako Hiraga, Kazuko Asada, Junji Hamuro, Chie Sotozono, Shigeru Kinoshita
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract This study aims to clarify the immunogenicity in acquired and innate immune responses of cultured human corneal endothelial cells (hCECs) applied for cell injection therapy, a newly established modality for corneal endothelium failures. Thir
Externí odkaz:
https://doaj.org/article/0ac3782f0d1648d4906ef7600e52e045
Cellular Interplay Through Extracellular Vesicle miR-184 Alleviates Corneal Endothelium Degeneration
Autor:
Tomoko Yamashita, PhD, Kazuko Asada, BEng, Morio Ueno, MD, PhD, Nao Hiramoto, PhD, Tomoko Fujita, BEd, Munetoyo Toda, PhD, Chie Sotozono, MD, PhD, Shigeru Kinoshita, MD, PhD, Junji Hamuro, PhD
Publikováno v:
Ophthalmology Science, Vol 2, Iss 4, Pp 100212- (2022)
Objective: The objective of the study was to reveal the presence of cellular interplay through extracellular vesicle (EV) microRNAs (miRs), to dampen the vicious cycle to degenerate human corneal endothelium (HCE) tissues. Design: Prospective, compar
Externí odkaz:
https://doaj.org/article/aa52be25f2df4ba9b6960edbc26679ba
Autor:
Junji Hamuro, Kazuko Asada, Morio Ueno, Tomoko Yamashita, Atsushi Mukai, Tomoko Fujita, Eiko Ito, Nao Hiramoto, Munetoyo Toda, Chie Sotozono, Shigeru Kinoshita
Publikováno v:
Investigative ophthalmologyvisual science. 63(4)
To reveal the mechanism triggering the functional disparity between degenerated and non-degenerated corneal endothelium cells in the water efflux from corneal stroma to the anterior chamber.The varied levels of the microRNA (miR)-34, miR-378, and miR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb69bf23abcea3005efbcf1d04b7760a
https://pubmed.ncbi.nlm.nih.gov/35475886
https://pubmed.ncbi.nlm.nih.gov/35475886
Autor:
Chie Sotozono, Junji Hamuro, Kazuko Asada, Monty Montoya, Munetoyo Toda, Shigeru Kinoshita, Morio Ueno, Asako Hiraga
Publikováno v:
Investigative ophthalmologyvisual science. 58(4)
Purpose Cultured human corneal endothelial cells (cHCECs) are anticipated to become an alternative to donor corneas for the treatment of corneal endothelial dysfunction. The aim of this study was to establish proper culture protocols to successfully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea67d7b53efc7c526d77ee0a639d4b9
https://pubmed.ncbi.nlm.nih.gov/28384722
https://pubmed.ncbi.nlm.nih.gov/28384722
Autor:
Munetoyo Toda, Kazuko Asada, Monty Montoya, Morio Ueno, Shigeru Kinoshita, Junji Hamuro, Chie Sotozono
Publikováno v:
Investigative ophthalmologyvisual science. 57(10)
Purpose To clarify whether cultured human corneal endothelial cells (cHCECs), heterogeneous in their differentiation state, exhibit distinctive energy metabolism with the aim to develop a reliable method to sort cHCECs applicable for regenerative med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0ae7723b46e587eaef19954f07ed49
https://pubmed.ncbi.nlm.nih.gov/27750287
https://pubmed.ncbi.nlm.nih.gov/27750287
Autor:
Takahiro Ochiya, Nobuyoshi Kosaka, Kazue Nagata, Munetoyo Toda, Kazuko Asada, Morio Ueno, Chie Sotozono, Junji Hamuro, Shigeru Kinoshita
Publikováno v:
Investigative ophthalmologyvisual science. 57(10)
Purpose We elucidate a method to use secreted miRNA profiles to qualify cultured human corneal endothelial cells (cHCECs) adaptable for cell-injection therapy. Methods The variations of cHCECs in their composites of heterogeneous subpopulations (SPs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf669950fb21e617c61af8cc37274947
https://pubmed.ncbi.nlm.nih.gov/27564521
https://pubmed.ncbi.nlm.nih.gov/27564521
Autor:
Junji Hamuro, Morio Ueno, Shigeru Kinoshita, Monty Montoya, Munetoyo Toda, Chie Sotozono, Asako Hiraga, Kazuko Asada
Publikováno v:
Investigative Opthalmology & Visual Science. 57:5509
Purpose To elucidate a noninvasive method to qualify and identify cultured human corneal endothelial cells (cHCECs) devoid of cell-state transition and adaptable for cell-based therapy. Methods The variations of cHCECs in their composition of heterog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a0ef3661b1b091aaffe270870314f5
https://doi.org/10.1167/iovs.16-19804
https://doi.org/10.1167/iovs.16-19804
Cell Homogeneity Indispensable for Regenerative Medicine by Cultured Human Corneal Endothelial Cells
Autor:
Kazuko Asada, Monty Montoya, Morio Ueno, Chie Sotozono, Asako Hiraga, Munetoyo Toda, Junji Hamuro, Shigeru Kinoshita, Ursula Schlötzer-Schrehardt
Publikováno v:
Investigative Opthalmology & Visual Science. 57:4749
Purpose To identify the subpopulation (SP) among heterogeneous cultured human corneal endothelial cells (cHCECs) devoid of cell-state transition applicable for cell-based therapy. Methods Subpopulation presence in cHCECs was confirmed via surface CD-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b14ae8b99cf65b6bdb875217e2a070f
https://doi.org/10.1167/iovs.16-19770
https://doi.org/10.1167/iovs.16-19770
Autor:
Monty Montoya, Junji Hamuro, Kazue Nagata, Morio Ueno, Munetoyo Toda, Ursula Schlötzer-Schrehardt, Kazuko Asada, Shigeru Kinoshita, Chie Sotozono
Publikováno v:
Investigative Opthalmology & Visual Science. 57:4295
Purpose To develop a method to qualify the function of cultured human corneal endothelial cells (cHCECs) applicable for clinical settings. Methods The diversified gene and microRNA (miRNA) signatures in HCECs from a variety of tissue donors were conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9bde643f06b67e3744d080c615da01e
https://doi.org/10.1167/iovs.16-19806
https://doi.org/10.1167/iovs.16-19806