Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Kazuko, Ueno"'
Autor:
Yuki Taniguchi, Toru Akune, Nao Nishida, Go Omori, Kim HA, Kazuko Ueno, Taku Saito, Takeshi Oichi, Asako Koike, Akihiko Mabuchi, Hiroyuki Oka, Shigeyuki Muraki, Yasushi Oshima, Hiroshi Kawaguchi, Kozo Nakamura, Katsushi Tokunaga, Sakae Tanaka, Noriko Yoshimura
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The molecular pathophysiology underlying lumbar spondylosis development remains unclear. To identify genetic factors associated with lumbar spondylosis, we conducted a genome-wide association study using 83 severe lumbar spondylosis cases an
Externí odkaz:
https://doaj.org/article/9000708e14c744cbb5a09750a3f74a41
Autor:
Yuki Hitomi, Yoshihiro Aiba, Kazuko Ueno, Nao Nishida, Yosuke Kawai, Minae Kawashima, Makoto Tsuiji, Chisato Iwabuchi, Sanami Takada, Noriko Miyake, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-12 (2022)
Abstract Background Ligation of CD28 with ligands such as CD80 or CD86 provides a critical second signal alongside antigen presentation by class II major histocompatibility complex expressed on antigen-presenting cells through the T cell antigen rece
Externí odkaz:
https://doaj.org/article/42bb9750cc5441d69b03584f5773a006
Autor:
Seik-Soon Khor, Kazuko Ueno, Nao Nishida, Minae Kawashima, Yosuke Kawai, Yoshihiro Aiba, Yuki Hitomi, Masao Nagasaki, Minoru Nakamura, Katsushi Tokunaga
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Primary biliary cholangitis (PBC) is a rare autoimmune disease with a clear predisposition for human leukocyte antigen (HLA)-DR/DQ-associated loss of immune tolerance for the E2 component of the pyruvate dehydrogenase complex. Three-field-resolution
Externí odkaz:
https://doaj.org/article/5083101fae4c4d3e8bfcee12a4a3bd7c
Autor:
Yuki Hitomi, Yoshihiro Aiba, Yosuke Kawai, Kaname Kojima, Kazuko Ueno, Nao Nishida, Minae Kawashima, Olivier Gervais, Seik-Soon Khor, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, Makoto Tsuiji
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Primary biliary cholangitis (PBC) is a chronic, progressive cholestatic liver disease in which intrahepatic bile ducts are destroyed by an autoimmune reaction. Our previous genome-wide association study (GWAS) identified chromosome 11q23.1 a
Externí odkaz:
https://doaj.org/article/cb5d749009044cbb96285ad674364512
Autor:
Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The conditions to induce human hepatic progenitor cells from other cell types are unclear. Here, the authors reprogram human endothelial cells to hepatic progenitor cells by expressing FOXA3, HNF1A and HNF6, capable of giving rise to hepatocytes and
Externí odkaz:
https://doaj.org/article/3527de58b192426485e6dd796f38531e
Autor:
Olivier Gervais, Kazuko Ueno, Yosuke Kawai, Yuki Hitomi, Kazuharu Misawa, Shunsuke Teraguchi, Yen-Yen Wang, Katsushi Tokunaga, Masao Nagasaki
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 7, Pp 2221-2228 (2020)
Over the past few decades, obesity has become a public health issue of global concern. Even though disparities exist between human populations, e.g., the higher liver fat content of the Japanese despite a lower body mass index (BMI), studies on the g
Externí odkaz:
https://doaj.org/article/38002075b3db491fab8d7425f64f5b81
Autor:
Kazuko Ueno, Yoshihiro Aiba, Yuki Hitomi, Shinji Shimoda, Hitomi Nakamura, Olivier Gervais, Yosuke Kawai, Minae Kawashima, Nao Nishida, Seik‐Soon Kohn, Kaname Kojima, Shinji Katsushima, Atsushi Naganuma, Kazuhiro Sugi, Tatsuji Komatsu, Tomohiko Mannami, Kouki Matsushita, Kaname Yoshizawa, Fujio Makita, Toshiki Nikami, Hideo Nishimura, Hiroshi Kouno, Hirotaka Kouno, Hajime Ohta, Takuya Komura, Satoru Tsuruta, Kazuhiko Yamauchi, Tatsuro Kobata, Amane Kitasato, Tamotsu Kuroki, Seigo Abiru, Shinya Nagaoka, Atsumasa Komori, Hiroshi Yatsuhashi, Kiyoshi Migita, Hiromasa Ohira, Atsushi Tanaka, Hajime Takikawa, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, PBC‐GWAS Consortium in Japan
Publikováno v:
Hepatology Communications, Vol 4, Iss 5, Pp 724-738 (2020)
Genome‐wide association studies (GWASs) in European and East Asian populations have identified more than 40 disease‐susceptibility genes in primary biliary cholangitis (PBC). The aim of this study is to computationally identify disease pathways,
Externí odkaz:
https://doaj.org/article/fe46dbbb09334b3f85f5095abc8398e3
Autor:
Takahiro Mori, Kazuko Ueno, Katsushi Tokunaga, Yosuke Kawai, Koichi Matsuda, Nao Nishida, Keigo Komine, Sakae Saito, Masao Nagasaki
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Background: Platinum derivatives are important treatment options for patients with esophageal carcinoma (EC), and a predictive marker for platinum-based therapy is needed for precision medicine. Patients and methods: This study contained two cohorts
Externí odkaz:
https://doaj.org/article/bc8a47fe77ed4872982cb30686c5e640
Autor:
Khun Zaw Latt, Kenjiro Honda, Myo Thiri, Yuki Hitomi, Yosuke Omae, Hiromi Sawai, Yosuke Kawai, Shunsuke Teraguchi, Kazuko Ueno, Masao Nagasaki, Akihiko Mabuchi, Hajime Kaga, Atsushi Komatsuda, Katsushi Tokunaga, Eisei Noiri
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract The associations of single nucleotide polymorphisms (SNPs) in PLA2R1 and HLA-DQA1, as well as HLA-DRB1*15:01-DQB1*06:02 haplotype with idiopathic membranous nephropathy (IMN) is well known. However, the primary associations of these loci sti
Externí odkaz:
https://doaj.org/article/f927285d7e104cbc8d6e45b143eb5502
Autor:
Zhiqian Yu, Kazuko Ueno, Ryo Funayama, Mai Sakai, Naoki Nariai, Kaname Kojima, Yoshie Kikuchi, Xue Li, Chiaki Ono, Junpei Kanatani, Jiro Ono, Kazuya Iwamoto, Kenji Hashimoto, Kengo Kinoshita, Keiko Nakayama, Masao Nagasaki, Hiroaki Tomita
Publikováno v:
Molecular Neurobiology. 60:1083-1098
Schizophrenia presents clinical and biological differences between males and females. This study investigated transcriptional profiles in the dorsolateral prefrontal cortex (DLPFC) using postmortem data from the largest RNA-sequencing (RNA-seq) datab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0c56f31b95ae0693bd0dd6c8535f51
https://doi.org/10.1007/s12035-022-03109-6
https://doi.org/10.1007/s12035-022-03109-6