Analysis and comparison of post-translational modifications of α-synuclein filaments in multiple system atrophy and dementia with Lewy bodies

Autor: Fuyuki Kametani, Marina Tahira, Masaki Takao, Tomoyasu Matsubara, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Masato Hasegawa

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)

Abstract Our previous cryogenic electron microscopy (cryoEM) analysis showed that the core structures of α-synuclein filaments accumulated in brains of patients diagnosed with dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) patient

Externí odkaz: https://doaj.org/article/9e5fa5e47de84ff9b3cc3071115f4a92

Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy

Autor: Sofia Lövestam, Manuel Schweighauser, Tomoyasu Matsubara, Shigeo Murayama, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Mari Yoshida, Airi Tarutani, Masato Hasegawa, Michel Goedert, Sjors H. W. Scheres

Publikováno v: FEBS Open Bio, Vol 11, Iss 4, Pp 999-1013 (2021)

The propagation of conformational strains by templated seeding is central to the prion concept. Seeded assembly of α‐synuclein into filaments is believed to underlie the prion‐like spreading of protein inclusions in a number of human neurodegene

Externí odkaz: https://doaj.org/article/35585117288f416087b434934b3a4a26

Structures of α-synuclein filaments from human brains with Lewy pathology

Autor: Yang Yang, Yang Shi, Manuel Schweighauser, Xianjun Zhang, Abhay Kotecha, Alexey G. Murzin, Holly J. Garringer, Patrick W. Cullinane, Yuko Saito, Tatiana Foroud, Thomas T. Warner, Kazuko Hasegawa, Ruben Vidal, Shigeo Murayama, Tamas Revesz, Bernardino Ghetti, Masato Hasegawa, Tammaryn Lashley, Sjors H. W. Scheres, Michel Goedert

Publikováno v: Nature. 610:791-795

Parkinson's disease (PD) is the most common movement disorder, with resting tremor, rigidity, bradykinesia and postural instability being major symptoms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6c4ab1f739fba5041dfa0da2356e5f
https://doi.org/10.1038/s41586-022-05319-3

Genome-wide association study identifies a new susceptibility locus inPLA2G4Cfor Multiple System Atrophy

Autor: Yasuo Nakahara, Jun Mitsui, Hidetoshi Date, Kristine Joyce Porto, Yasuhiro Hayashi, Atsushi Yamashita, Yoshio Kusakabe, Takashi Matsukawa, Hiroyuki Ishiura, Tsutomu Yasuda, Atsushi Iwata, Jun Goto, Yaeko Ichikawa, Yoshio Momose, Yuji Takahashi, Tatsushi Toda, Rikifumi Ohta, Jun Yoshimura, Shinichi Morishita, Emil K Gustavsson, Darren Christy, Melissa Maczis, Matthew J. Farrer, Han-Joon Kim, Sung-Sup Park, Beomseok Jeon, Jin Zhang, Weihong Gu, Sonja W. Scholz, Andrew B. Singleton, Henry Houlden, Ichiro Yabe, Hidenao Sasaki, Masaaki Matsushima, Hiroshi Takashima, Akio Kikuchi, Masashi Aoki, Kenju Hara, Akiyoshi Kakita, Mitsunori Yamada, Hitoshi Takahashi, Osamu Onodera, Masatoyo Nishizawa, Hirohisa Watanabe, Mizuki Ito, Gen Sobue, Kinya Ishikawa, Hidehiro Mizusawa, Kazuaki Kanai, Satoshi Kuwabara, Kimihito Arai, Shigeru Koyano, Yoshiyuki Kuroiwa, Kazuko Hasegawa, Tatsuhiko Yuasa, Kenichi Yasui, Kenji Nakashima, Hijiri Ito, Yuishin Izumi, Ryuji Kaji, Takeo Kato, Susumu Kusunoki, Yasushi Osaki, Masahiro Horiuchi, Ken Yamamoto, Mihoko Shimada, Taku Miyagawa, Yosuke Kawai, Nao Nishida, Katsushi Tokunaga, Alexandra Dürr, Alexis Brice, Alessandro Filla, Thomas Klockgether, Ullrich Wüllner, Caroline M. Tanner, Walter A. Kukull, Virginia M.-Y. Lee, Eliezer Masliah, Phillip A. Low, Paola Sandroni, Laurie Ozelius, Tatiana Foroud, Shoji Tsuji

To elucidate the molecular basis of multiple system atrophy (MSA), a neurodegenerative disease, we conducted a genome-wide association study (GWAS) in a Japanese MSA case/control series followed by replication studies in Japanese, Korean, Chinese, Eu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0ca23eb995d2b34d1429411448aeb26
https://doi.org/10.1101/2023.05.02.23289328

Frequency of anti-IgLON5 disease in patients who meet the clinical diagnostic criteria for progressive supranuclear palsy/corticobasal syndrome (S22.010)

Autor: Yoya Ono, Akira Takekoshi, Nobuaki Yoshikura, Hiroshi Takigawa, Ikuko Aiba, Ritsuko Hanajima, Hisanori Kowa, Masato Kanazawa, Takahiko Tokuda, Aya Midori Tokumaru, Mitsuya Morita, Kazuko Hasegawa, Kenji Nakashima, Takeshi Ikeuchi, Akio Kimura, Takayoshi Shimohata

Publikováno v: Monday, April 24.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dd542ee300b827795eb9317ae0cd8af
https://doi.org/10.1212/wnl.0000000000202665