Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kazuki Tawaratsumida"'
Autor:
Vanessa Redecke, Kazuki Tawaratsumida, Erin T. Larragoite, Elizabeth S. C. P. Williams, Vicente Planelles, Adam M. Spivak, Lincoln Hirayama, Marc Elgort, Shane Swenson, Rick Smith, Bryan Worthen, Russ Zimmerman, Patricia Slev, Ben Cahoon, Mark Astill, Hans Häcker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Diagnostic tests that detect antibodies (AB) against SARS-CoV-2 for evaluation of seroprevalence and guidance of health care measures are important tools for managing the COVID-19 pandemic. Current tests have certain limitations with regard
Externí odkaz:
https://doaj.org/article/1655f619167244489c5e59a7785e3869
A phospho-tyrosine-based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity
Autor:
Kazuki Tawaratsumida, Vanessa Redecke, Ruiqiong Wu, Jeeba Kuriakose, Jill J. Bouchard, Tanja Mittag, Brian K. Lohman, Ashutosh Mishra, Anthony A. High, Hans Häcker
Publikováno v:
Science advances. 8(27)
Toll-like receptors (TLRs) recognize pathogen- and host-derived factors and control immune responses via the adaptor protein MyD88 and members of the interferon regulatory transcription factor (IRF) family. IRFs orchestrate key effector functions, in
Autor:
Elizabeth S. C. P. Williams, Shane Swenson, Mark E. Astill, Patricia R. Slev, Vanessa Redecke, Bryan Worthen, Marc G. Elgort, Kazuki Tawaratsumida, Richard Smith, Adam M. Spivak, Ben Cahoon, Russ Zimmerman, Erin T. Larragoite, Vicente Planelles, Lincoln Hirayama, Hans Haecker
Publikováno v:
Research Square
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Diagnostic tests that detect antibodies (AB) against SARS-CoV-2 for evaluation of seroprevalence and guidance of health care measures are important tools for managing the COVID-19 pandemic. Current tests have certain limitations with regard to turnar
Autor:
Hans Häcker, Julie A. Pollock, Wenwei Lin, Taosheng Chen, Vanessa Redecke, Yizhe Chen, R. Kiplin Guy, Sirish K. Ippagunta, Naina Sharma, Kazuki Tawaratsumida, Jaeki Min, Anthony A. High, John A. Katzenellenbogen
Publikováno v:
Sci Signal
Toll-like receptors (TLRs) recognize various pathogen- and host tissue-derived molecules and initiate inflammatory immune responses. Exaggerated or prolonged TLR activation, however, can promote etiologically diverse diseases, such as bacterial sepsi
Autor:
Anthony A. High, Hans Häcker, Richard J. Webby, Vanessa Redecke, Van Phan, Eike R. Hrincius, Kazuki Tawaratsumida
Publikováno v:
Journal of Virology. 88:9038-9048
Influenza A virus (IAV) replication depends on the interaction of virus proteins with host factors. The viral nonstructural protein 1 (NS1) is essential in this process by targeting diverse cellular functions, including mRNA splicing and translation,
Publikováno v:
Innate Immunity. 19:132-139
Bacteroides fragilis is found among the normal intestinal flora and is involved in host immunostimulation via TLR2. Its cell surface components, such as LPS and capsular polysaccharides, were reported to participate in host immunostimulation. In this
Autor:
Takashi Yamazaki, Mizuho Hasegawa, Yun Gi Kim, Nobuhiko Kamada, Kazuki Tawaratsumida, Naohiro Inohara, Gabriel Núñez
Publikováno v:
The Journal of Immunology. 186:4872-4880
Clostridium difficile is a Gram-positive obligate anaerobic pathogen that causes pseudomembranous colitis in antibiotics-treated individuals. However, host immune protective mechanisms against C. difficile are largely unknown. In this study, we show
Autor:
Toshifumi Osaka, Mizuho Hasegawa, Kazuki Tawaratsumida, Grace Y. Chen, Hiroyuki Tada, Naohiro Inohara, Takashi Yamazaki, Gabriel Núñez, Satoshi Tsuneda
Publikováno v:
Infection and Immunity. 78:639-650
Commensal bacteria possess immunostimulatory activities that can modulate host responses to affect development and homeostasis in the intestine. However, how different populations of resident bacteria stimulate the immune system remains largely unkno
Autor:
Mami Katsumoto, Yasuo Suda, Yukari Fujimoto, Masahito Hashimoto, Maiko Furuyashiki, Kazuki Tawaratsumida, Koichi Fukase
Publikováno v:
Journal of Biological Chemistry. 284:9147-9152
Staphylococcus aureus is known to activate mammalian immune cells through Toll-like receptor 2 (TLR2). We recently demonstrated that a lipoprotein fraction obtained from S. aureus by Triton X-114 phase partitioning is a potent activator of TLR2. In t
Autor:
Masahito Hashimoto, Hiroyuki Kariya, Kazue Aoyama, Toshihide Tamura, Kazuki Tawaratsumida, Yasuo Suda
Publikováno v:
International Immunology. 18:355-362
Lipoteichoic acid (LTA) derived from Staphylococcus aureus is reported to be a ligand of Toll-like receptor 2 (TLR2). In this study, we demonstrated that lipoproteins obtained from S. aureus are potent activators of TLR2. A fraction obtained by Trito