Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kazuki Nagatsu"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Ricin toxin A chain (RTA), from Ricinus communis, is a deadly protein that inactivates ribosomes by degrading an adenine residue at position 4324 in 28S rRNA. Recently, we have demonstrated that pterin-7-carboxamides with peptide pendants were potent
Externí odkaz:
https://doaj.org/article/e032e04e7fd74899b46396c48dd1ad16
Autor:
Ryota Saito, Masaru Goto, Shun Katakura, Taro Ohba, Rena Kawata, Kazuki Nagatsu, Shoko Higashi, Kaede Kurisu, Kaori Matsumoto, Kouta Ohtsuka
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0277770 (2022)
The Ricin toxin A chain (RTA), which depurinates an adenine base at a specific region of the ribosome leading to death, has two adjacent specificity pockets in its active site. Based on this structural information, many attempts have been made to dev
Externí odkaz:
https://doaj.org/article/fdb3451072e8499da9cac41061bfd8f7