Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kazuhito Tawaramoto"'
Autor:
Kazuhito Tawaramoto1,2, Hideaki Kaneto1 kaneto@med.kawasaki-m.ac.jp, Mitsuru Hashiramoto1, Fumiko Kawasaki3, Fuminori Tatsumi1, Masashi Shimoda1, Shinji Kamei1, Michihiro Matsuki1, Tomoatsu Mune1, Kohei Kaku3
Publikováno v:
Diabetology & Metabolic Syndrome. 9/18/2015, Vol. 7 Issue 1, p1-4. 4p.
Autor:
Yukiko Kanda, Koji Nakashima, Kohei Kaku, Tomohiko Kimura, Sumiko Hamamoto, Masashi Shimoda, Mitsuru Hashiramoto, Kazuhito Tawaramoto, Hidenori Hirukawa
Publikováno v:
The Journal of Nutritional Biochemistry. 26:219-226
To assess the molecular mechanisms by which dietary restriction preserves the β-cell mass and function in diabetic db/db mice. Male db/db mice were divided into two groups with or without diet restriction. Daily food intake of db/db mice was adjuste
Autor:
Masafumi Matsuda, Kohei Kaku, Masashi Shimoda, Shinji Kamei, Yukiko Kanda-Kimura, Fuminori Tatsumi, Atsushi Obata, Sumiko Hamamoto, Tomoatsu Mune, Tomohiko Kimura, Mitsuru Hashiramoto, Hideaki Kaneto, Kazuhito Tawaramoto
Publikováno v:
Endocrine Journal. 62:741-747
It is known that reactive oxygen species (ROS) are involved in the development of insulin resistance as well as pancreatic β-cell dysfunction both of which are often observed in type 2 diabetes. In this study, we evaluated the effects of azelnidipin
Autor:
Fumiko Kawasaki, Tomoatsu Mune, Kazuhito Tawaramoto, Hidenori Hirukawa, Mitsuru Hashiramoto, Masashi Shimoda, Tomohiko Kimura, Yukiko Kanda-Kimura, Takatoshi Anno, Kohei Kaku, Michihiro Matsuki, Fuminori Tatsumi
Publikováno v:
Diabetes Research and Clinical Practice. 101:35-44
To evaluate the efficacy of miglitol and mitiglinide alone or in combination on the metabolic profile and incretin secretion in Japanese type 2 diabetes patients.Patients on diet and exercise with or without metformin, were randomized to receive eith
Autor:
Wataru Ogawa, Kohei Kaku, Noriaki Emoto, Kazuhito Tawaramoto, Mitsuru Hashiramoto, Yukiko Kanda, Masashi Yanagisawa, Ko Kotani, Tomoki Nagare, Hiroshi Sakaue, Tetsuo Noda, Masato Kasuga
Publikováno v:
Molecular Endocrinology. 26:95-109
The phosphatidylinositol 3-kinase signaling pathway in vascular endothelial cells is important for systemic angiogenesis and glucose metabolism. In this study, we addressed the precise role of the 3-phosphoinositide-dependent protein kinase 1 (PDK1)-
Autor:
Koji Nakashima, Kohei Kaku, Sumiko Hamamoto, Yukiko Kanda, Kazuhito Tawaramoto, Mitsuru Hashiramoto, Fumiko Kawasaki, Michihiro Matsuki, Masashi Shimoda
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism
Pioglitazone preserves pancreatic β-cell morphology and function in diabetic animal models. In this study, we investigated the molecular mechanisms by which pioglitazone protects β-cells in diabetic db/db mice. In addition to the morphological anal
Autor:
Kazuhito Tawaramoto, Makoto Shigetoh, Kenji Kohara, Michihiro Matsuki, Yukiko Kanda, Kou Kotani, Fumiko Kawasaki, Masafumi Matsuda, Masashi Shimoda, Kohei Kaku
Publikováno v:
Endocrine Journal. 54:571-576
To compare the pharmacokinetic and pharmacodynamic effects of glimepiride between once- and twice-daily dosing in type 2 diabetic patients. Eight Japanese type 2 diabetic patients, who had been treated with 2 mg glimepiride alone over 4 weeks (age 40
Autor:
Mitsuru Hashiramoto, Michihiro Matsuki, Hideaki Kaneto, Kazuhito Tawaramoto, Sumiko Hamamoto, Masashi Shimoda, Shinji Kamei, Fumiko Kawasaki, Tomoatsu Mune, Yukiko Kanda-Kimura, Kohei Kaku
Publikováno v:
Diabetesmetabolism. 41(5)
Diabetes & Metabolism - In Press.Proof corrected by the author Available online since lundi 8 juin 2015
Autor:
Mitsuru Hashiramoto, Tomohiko Kimura, Kenji Kohara, Seizo Okauchi, Kohei Kaku, Atsushi Obata, Hideaki Kaneto, Kazuhito Tawaramoto, Sumiko Hamamoto, Hidenori Hirukawa, Masashi Shimoda
Publikováno v:
Molecular and cellular endocrinology. 413
We investigated the effects of long- and short-term treatment with pioglitazone (Pio) and/or alogliptin (Alo) on β-cells in diabetic db/db mice. Six-week-old male db/db mice received Pio (25 mg/kg, oral) and/or Alo (30 mg/kg, oral) for 4 weeks and f
Autor:
Hideaki Kaneto, Kazuhito Tawaramoto, Ryo Shigemoto, Kohei Kaku, Akihito Tanabe, Fuminori Tatsumi, Sumiko Ejiri, Masashi Shimoda, Shinji Kamei, Kenji Kohara, Tomohiko Kimura, Takatoshi Anno, Fumiko Kawasaki, Tomoatsu Mune, Atsushi Obata
Publikováno v:
Journal of Diabetes Investigation
Insulin autoimmune syndrome (IAS), which was first reported by Hirata et al.1, is known to be induced by the use of various kinds of drugs containing the sulfhydryl (SH) group, such as methimazole, or the use of α‐lipoic acid2, 3.