Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Kazuhito Ikeda"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 126, Iss 2, Pp 164-167 (2014)
Abstract.: Patients with psychiatric disorders, including schizophrenia, are reported to suffer from sleep disorders. In this study, we investigated the effects of lurasidone, an atypical antipsychotic, on sleep architecture in rats using sleep elect
Externí odkaz:
https://doaj.org/article/0e6b5d0e100f47be93cc89aa69478845
Autor:
Yoshihiro Iwamura, Tatsuo Nakayama, Atsushi Matsumoto, Yuji Ogi, Masataka Yamaguchi, Atsushi Kobayashi, Kenji Matsumoto, Yasunori Katsura, Naho Konoike, Katsuki Nakamura, Kazuhito Ikeda
Publikováno v:
Journal of neurophysiology. 128(1)
Abnormalities of auditory steady-state responses (ASSRs) and the effects of antipsychotic drugs on ASSRs have been investigated in patients with schizophrenia. It is presumed that drugs do not directly affect ASSRs because its abnormalities are assoc
Autor:
Kazuhito Ikeda, Masao Goda, Shiori Taga, Kantaro Nishigori, Takeshi Enomoto, Yuki Fujii, Ayaka Tatara, Atsushi Kitamura, Mami Kamada, Takashi Hashimoto, Yohei Nishizato
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 371:692-702
In our drug discovery program, we identified a novel orally available and brain-penetrant phosphodiesterase (PDE) 1 inhibitor, 3-methyl-7-(tetrahydro-2H-pyran-4-yl)-2-{[trans-4-(trifluoromethyl)cyclohexyl]-methoxy}imidazo[5,1-f][1,2,4]triazin-4(3H)-o
Autor:
Kazuhito Ikeda, Takeshi Enomoto
Publikováno v:
Folia Pharmacologica Japonica. 153:28-34
The drug discovery activities for novel compounds with the superior efficacies to current drugs have been largely unsuccessful in the psychiatric field. One of the main reasons is the lack of appropriate behavioral assays and animal models for psychi
Autor:
Yoshihiro, Iwamura, Tomokazu, Nakako, Atsushi, Matsumoto, Yuji, Ogi, Masataka, Yamaguchi, Atsushi, Kobayashi, Kenji, Matsumoto, Yasunori, Katsura, Kazuhito, Ikeda
Publikováno v:
Behavioural Brain Research. 428:113883
The ameliorating effect of risperidone on apomorphine-induced stereotyped behavior and inhibition of auditory sensory gating was investigated using rhesus monkeys. The total duration of the stereotyped behavior observed in the control group was 43.7
Autor:
Masao Goda, Kazuhito Ikeda, Atsushi Kitamura, Erika Wada, Takeshi Enomoto, Tomokazu Nakako, Yuki Fujii
Publikováno v:
Pharmacology Biochemistry and Behavior. 205:173183
The enzyme phosphodiesterase 1 (PDE1) is highly expressed in the striatum and cortex. However, its role in corticostriatal function has not been fully investigated. The present study was aimed at evaluating the therapeutic potential of PDE1 inhibitor
Autor:
Katsuki Nakamura, Yuji Ogi, Kazuhito Ikeda, Manato Kotani, Kenji Matsumoto, Tomokazu Nakako, Naho Konoike, Kohei Shimono, Toshihiro Yoneyama
Publikováno v:
Psychoneuroendocrinology. 83:42-48
Eye tracking systems are used to investigate eyes position and gaze patterns presumed as eye contact in humans. Eye contact is a useful biomarker of social communication and known to be deficient in patients with autism spectrum disorders (ASDs). Int
Publikováno v:
Behavioural Pharmacology. 28:313-317
As pupil size is affected by psychotropic drugs in all mammals, it has been used as a well-established clinical indicator for the preclinical and clinical development of novel drugs. It has been reported that activation of the serotonin (5-HT)1A rece
Publikováno v:
Journal of Liposome Research. 27:221-227
Phospholipids and cholesterols are being spotlighted as raw materials for preparing liposomes, one of the key compounds for drug delivery systems (DDS), and as base compounds for converting water-soluble drugs to fat-soluble drugs. Other applications
Publikováno v:
Behavioral neuroscience. 132(6)
Effort-based decision-making paradigms have recently been used to measure motivation in healthy subjects and patients with neuropsychiatric disorders. In the present study, we developed a novel effort-discounting paradigm using a touch-panel system i