Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kazuhito Gotoh"'
Autor:
Kentaro Nakashima, Yuya Kunisaki, Kentaro Hosokawa, Kazuhito Gotoh, Hisayuki Yao, Ryosuke Yuta, Yuichiro Semba, Jumpei Nogami, Yoshikane Kikushige, Patrick S. Stumpf, Ben D. MacArthur, Dongchon Kang, Koichi Akashi, Shouichi Ohga, Fumio Arai
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Protection of telomeres 1a (POT1a) is a telomere binding protein. A decrease of POT1a is related to myeloid-skewed haematopoiesis with ageing, suggesting that protection of telomeres is essential to sustain multi-potency. Since mesenchymal s
Externí odkaz:
https://doaj.org/article/e55a84a5ea34472ba25f72989b580bf5
Autor:
Masakazu Fujii, Daiki Setoyama, Kazuhito Gotoh, Yushi Dozono, Mikako Yagi, Masataka Ikeda, Tomomi Ide, Takeshi Uchiumi, Dongchon Kang
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104889- (2022)
Summary: The occurrence of diet-induced obesity has been increasing worldwide and has become a major health concern. Mitochondria are densely distributed in brown adipose tissue and are involved in lipid consumption. Therefore, increasing energy expe
Externí odkaz:
https://doaj.org/article/d94000035ebc4e8583b49ba634ecd832
Autor:
Yuya Nakashima, Kazuhito Gotoh, Soichi Mizuguchi, Daiki Setoyama, Yurie Takata, Toshihiro Kanno, Dongchon Kang
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
The NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) inflammasome has been linked to the pathogenesis of a wide variety of human diseases. Although many drugs and inhibitors have been developed to treat NLRP3-associated diseases, o
Externí odkaz:
https://doaj.org/article/f1e144d3234d43a5a7bcf0b11f4f884c
Autor:
Soichi Mizuguchi, Kazuhito Gotoh, Yuya Nakashima, Daiki Setoyama, Yurie Takata, Shouichi Ohga, Dongchon Kang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Psoriasis is a common immune-mediated, chronic, inflammatory skin disease that affects approximately 2–3% of the population worldwide. Although there is increasing evidence regarding the essential roles of the interleukin (IL)-23/IL-17 axis and den
Externí odkaz:
https://doaj.org/article/6d763983d1aa4b64b97602c4b2d4fa49
Metabolic analysis of mouse bone-marrow-derived dendritic cells using an extracellular flux analyzer
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100401- (2021)
Summary: Dendritic cell (DC) maturation induced by Toll-like receptor (TLR) agonists requires the activation of downstream metabolic changes. Here, we provide a detailed protocol to measure glycolysis, mitochondrial respiration, and fatty acid oxidat
Externí odkaz:
https://doaj.org/article/317a6c55b6ce43cab57f36e34a3fe170
Autor:
Kazuhito Gotoh, Yuya Kunisaki, Soichi Mizuguchi, Daiki Setoyama, Kentaro Hosokawa, Hisayuki Yao, Yuya Nakashima, Mikako Yagi, Takeshi Uchiumi, Yuichiro Semba, Jumpei Nogami, Koichi Akashi, Fumio Arai, Dongchon Kang
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101654- (2020)
Summary: p32/C1qbp regulates mitochondrial protein synthesis and is essential for oxidative phosphorylation in mitochondria. Although dysfunction of p32/C1qbp impairs fetal development and immune responses, its role in hematopoietic differentiation r
Externí odkaz:
https://doaj.org/article/8fac0b422e154639b77f09f8c8a29f4f
Autor:
Shigeru Matsuda, Takehiro Yasukawa, Yuriko Sakaguchi, Kenji Ichiyanagi, Motoko Unoki, Kazuhito Gotoh, Kei Fukuda, Hiroyuki Sasaki, Tsutomu Suzuki, Dongchon Kang
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Whilst 5-methylcytosine (5mC) is a major epigenetic mark in the nuclear DNA in mammals, whether or not mitochondrial DNA (mtDNA) receives 5mC modification remains controversial. Herein, we exhaustively analysed mouse mtDNA using three method
Externí odkaz:
https://doaj.org/article/292dcfe424644832b38fb2830dc1be9a
Autor:
Katsuhiko Sasaki, Kazuhito Gotoh, Sho Miake, Daiki Setoyama, Mikako Yagi, Ko Igami, Takeshi Uchiumi, Donchon Kang
Publikováno v:
EBioMedicine, Vol 20, Iss C, Pp 161-172 (2017)
Sepsis is a major cause of morbidity and mortality in seriously ill patients and mitochondrial dysfunction is associated with poor outcomes in septic patients. Although interleukin-6 (IL-6) is a good prognostic marker for sepsis, the relationship bet
Externí odkaz:
https://doaj.org/article/67e14ef3cd8b424cb629d03cffd8231d
Autor:
Kazuhito Gotoh, Takafumi Morisaki, Daiki Setoyama, Katsuhiko Sasaki, Mikako Yagi, Ko Igami, Soichi Mizuguchi, Takeshi Uchiumi, Yoshinori Fukui, Dongchon Kang
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1800-1815.e4 (2018)
Summary: Dendritic cell (DC) maturation induced by Toll-like receptor agonists requires activation of downstream signal transduction and metabolic changes. The endogenous metabolite citrate has recently emerged as a modulator of DC activation. Howeve
Externí odkaz:
https://doaj.org/article/6c1e87d4e40d4ffc823458723ec76953
Autor:
Ko Igami, Hiroki Kittaka, Mikako Yagi, Kazuhito Gotoh, Yuichi Matsushima, Tomomi Ide, Masataka Ikeda, Saori Ueda, Shin-Ichiro Nitta, Manami Hayakawa, Nakayama, Keiichi I., Masaki Matsumoto, Dongchon Kang, Takeshi Uchiumi
Publikováno v:
Life Science Alliance; Jul2024, Vol. 7 Issue 7, p1-15, 15p