Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kazuhisa Tsunoyama"'
Autor:
Katsura, Nozawa, Kazuhisa, Tsunoyama
Publikováno v:
Folia Pharmacologica Japonica. 158:3-9
Recent rapid progress in big data and breakthrough AI technologies have brought about significant changes in the medical field as well. Although biomedical literature databases contain so many articles that it is impossible to read them all, AI techn
Autor:
Masayuki Komatsu, Hitoshi Ichikawa, Fumiko Chiwaki, Hiromi Sakamoto, Rie Komatsuzaki, Makoto Asaumi, Kazuhisa Tsunoyama, Takeo Fukagawa, Hiromichi Matsushita, Narikazu Boku, Keisuke Matsusaki, Fumitaka Takeshita, Teruhiko Yoshida, Hiroki Sasaki
Publikováno v:
Oncogene. 41:4779-4794
Genetic alteration of Rho GTPase-activating proteins (ARHGAP) and GTPase RhoA is a hallmark of diffuse-type gastric cancer and elucidating its biological significance is critical to comprehensively understanding this malignancy. Here, we report that
Autor:
Kazuhisa Tsunoyama, Katsura Nozawa
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 95:2-S28
Autor:
Kazuhisa Tsunoyama
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 92:3-CS4
Autor:
Masaya Orita, Yosuke Hagiwara, Kazuki Ohno, Kazuhisa Tsunoyama, Ayako Moritomo, Toshihiro Watanabe
Publikováno v:
Expert Opinion on Drug Discovery. 8:1-5
The ever-increasing rate of drug discovery data has complicated data analysis and potentially compromised data quality due to factors such as data handling errors. Parallel to this concern is the rise in blatant scientific misconduct. Combined, these
Publikováno v:
Journal of Chemical Information and Modeling. 48:949-957
In chemoinformatics, searching for compounds which are structurally diverse and share a biological activity is called scaffold hopping. Scaffold hopping is important since it can be used to obtain alternative structures when the compound under develo
Autor:
Hiroki, Shirai, Catherine, Prades, Randi, Vita, Paolo, Marcatili, Bojana, Popovic, Jianqing, Xu, John P, Overington, Kazunori, Hirayama, Shinji, Soga, Kazuhisa, Tsunoyama, Dominic, Clark, Marie-Paule, Lefranc, Kazuyoshi, Ikeda
Publikováno v:
Biochimica et biophysica acta. 1844(11)
More and more antibody therapeutics are being approved every year, mainly due to their high efficacy and antigen selectivity. However, it is still difficult to identify the antigen, and thereby the function, of an antibody if no other information is
Autor:
Kazuyoshi Ikeda, Kazuhisa Tsunoyama, Dominic Clark, John P. Overington, Hiroki Shirai, Paolo Marcatili, Catherine Prades, Randi Vita, Jianqing Xu, Hirayama Kazunori, Marie-Paule Lefranc, Shinji Soga, Bojana Popovic
Publikováno v:
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2014, 1844 (11), pp.2002-2015. ⟨10.1016/j.bbapap.2014.07.006⟩
BBA-Biochimica et Biophysica Acta, Elsevier, 2014, 1844 (11), pp.2002-2015. ⟨10.1016/j.bbapap.2014.07.006⟩
More and more antibody therapeutics are being approved every year, mainly due to their high efficacy and antigen selectivity. However, it is still difficult to identify the antigen, and thereby the function, of an antibody if no other information is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4939ebc5de3b756fa9dc4c8c5e65f3c
https://hal.archives-ouvertes.fr/hal-01088585
https://hal.archives-ouvertes.fr/hal-01088585
Publikováno v:
Journal of chemical information and modeling. 50(5)
To clarify the differences between commercially available compounds, clinical candidates, and launched drugs with regard to distribution of physicochemical properties and to characterize the correlation between physicochemical properties, we conducte
Publikováno v:
ChemInform. 39
In chemoinformatics, searching for compounds which are structurally diverse and share a biological activity is called scaffold hopping. Scaffold hopping is important since it can be used to obtain alternative structures when the compound under develo