Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kazuhisa Ishimoto"'
Autor:
Kazuhisa Ishimoto, Hiroshi Watanabe, Kiyohito Okumiya, Kazuaki Tatara, Yushiro Yamashita, Jun Iwahashi, Mariko Teramachi, Kenji Gotoh, Shizuo Shindou, Yuhei Tanaka
Publikováno v:
Journal of Infection and Chemotherapy. 26:280-284
Streptococcus pyogenes (Group A streptococci: GAS) are known to cause a wide variety of human illnesses, some of which can be life-threatening. Usually, penicillin is the first-choice agent for the treatment of GAS infections. For patients with penic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b875c67aad992596fa4704e893e953e
https://doi.org/10.1016/j.jiac.2019.10.004
https://doi.org/10.1016/j.jiac.2019.10.004
Publikováno v:
Tetrahedron. 74:5779-5790
A practical chromatography-free synthesis of a potent polo-like kinase-1 inhibitor possessing a unique 5,6-dihydroimidazolo[1,5-f]pteridine structure has been developed. We showed that key cyanoimidazole ring formation could be conducted at benign te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::772b9be03a20069e4160db75b58c213b
https://doi.org/10.1016/j.tet.2018.08.020
https://doi.org/10.1016/j.tet.2018.08.020
Publikováno v:
Organic Process Research & Development. 21:2001-2011
A practical synthesis of a peripherally selective noradrenaline reuptake inhibitor that has a chiral 6,7-trans-disubstituted-1,4-oxazepane as a new class of scaffold is described. The amino alcohol possessing the desired stereochemistry was obtained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a70f616564aa18a4989e21183cc7fdc
https://doi.org/10.1021/acs.oprd.7b00313
https://doi.org/10.1021/acs.oprd.7b00313
Publikováno v:
Tetrahedron. 71:407-418
Oxidative cyclization of 1-(pyridin-2-yl)guanidine derivatives using N -chlorosuccinimide and aqueous potassium carbonate has been investigated. Chlorination of 1-(5-nitropyridin-2-yl)guanidine by N -chlorosuccinimide in methanol followed by addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aa1708fddbda053d98dc6e27d158966
https://doi.org/10.1016/j.tet.2014.12.015
https://doi.org/10.1016/j.tet.2014.12.015
Publikováno v:
Organic Process Research & Development. 18:122-134
A practical and scalable synthesis of the vascular endothelial growth factor receptor-2 (VEGFR-2) kinase inhibitor 1 has been developed. The key features of the process development include facile preparation of the key raw material 3-amino-4-fluoroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d31ce4f01fed27cda4b5df4b56ca7c5
https://doi.org/10.1021/op4002824
https://doi.org/10.1021/op4002824
Publikováno v:
Tetrahedron. 69:8564-8571
A convergent and streamlined synthesis of selective vascular endothelial growth factor receptor (VEGFR) 2 kinase inhibitors has been achieved using a synthetic strategy based on an SNAr reaction of 6-chloroimidazo[1,2-b]pyridazine with phenols in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4be12b0f1fda126d8550b8c82ebee47
https://doi.org/10.1016/j.tet.2013.07.087
https://doi.org/10.1016/j.tet.2013.07.087
Autor:
Yushiro Yamashita, Mariko Teramachi, Shizuo Shindou, Kenji Gotoh, Naoki Tsumura, Yuhei Tanaka, Kazuhisa Ishimoto
Publikováno v:
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 22(11)
Here we report the molecular epidemiology of macrolide-resistant Streptococcus pyogenes (group A streptococci, GAS) isolated from children with pharyngotonsillitis between 2011 and 2013 in Japan. In 299 isolates, 124 (41.5%) isolates were macrolide-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c89f7a5ec35131379f6fc30c90e76aa
https://pubmed.ncbi.nlm.nih.gov/27645122
https://pubmed.ncbi.nlm.nih.gov/27645122
Publikováno v:
ChemInform. 46
Oxidative cyclization of pyridinyl guanidine derivatives using N-chlorosuccinimide and aqueous potassium carbonate gives the entitled triazolo[1,5-a]pyridin-2-amines in one-pot and, in some cases, also unexpected triazolo[4,3-a]pyridin-3-amine produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdfe2a466f9bd95bb8a02d4e32657698
https://doi.org/10.1002/chin.201521160
https://doi.org/10.1002/chin.201521160
Autor:
Kazuhisa Ishimoto, Bumhwan Lee, Yutaka Yamagata, Joon-wan Kim, Teruyuki Nagamune, Akihiko Tanioka
Publikováno v:
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 36:1370-1375
In recent years new methods for active protein film fabrication have been rapidly developing. One of these methods is the electrospray deposition (ESD) method. This method allows the spontaneous deposition of many identical dots and has a remarkable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eeea37dbe7dfb8ab37965bb0f40d932
https://doi.org/10.1252/jcej.36.1370
https://doi.org/10.1252/jcej.36.1370
Publikováno v:
ChemInform. 45
A convergent and streamlined synthesis of selective vascular endothelial growth factor receptor (VEGFR) 2 kinase inhibitors has been achieved using a synthetic strategy based on an SNAr reaction of 6-chloroimidazo[1,2-b]pyridazine with phenols in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::968d6cca2cefa2676244c676b20ddc65
https://doi.org/10.1002/chin.201406196
https://doi.org/10.1002/chin.201406196