Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kazuhisa Honma"'
Autor:
Mitsuo Oshimura, Toshiaki Tabata, Narumi Uno, Shuta Takata, Genki Hichiwa, Iori Kanazawa, Takeshi Endo, Kazuhisa Honma, Yayan Wang, Kanako Kazuki, Haochen Tu, Yuichi Iida, Satoshi Abe, Yasuhiro Kazuki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Human mesenchymal stem cells (hMSCs) with extended lifespan and differentiation potential that can recapitulate in vivo characteristics could significantly contribute to basic research, drug development, and cell therapy. Specifically, they
Externí odkaz:
https://doaj.org/article/d1875669cd4f4913869ea0d4478c2704
Autor:
Narumi Uno, Hiroyuki Satofuka, Hitomaru Miyamoto, Kazuhisa Honma, Teruhiko Suzuki, Kyotaro Yamazaki, Ryota Ito, Takashi Moriwaki, Shusei Hamamichi, Kazuma Tomizuka, Mitsuo Oshimura, Yasuhiro Kazuki
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 391-403 (2023)
Microcell-mediated chromosome transfer is an attractive technique for transferring chromosomes from donor cells to recipient cells and has enabled the generation of cell lines and humanized animal models that contain megabase-sized gene(s). However,
Externí odkaz:
https://doaj.org/article/6a1d3237830545f0abde19627d69f0ec
Autor:
Hiroyuki Satofuka, Yayan Wang, Kyotaro Yamazaki, Shusei Hamamichi, Takeshi Fukuhara, Abdur Rafique, Nana Osako, Iori Kanazawa, Takeshi Endo, Naomi Miyake, Kazuhisa Honma, Yuichi Nagashima, Genki Hichiwa, Kazuto Shimoya, Satoshi Abe, Takashi Moriwaki, Yasufumi Murakami, Xu Gao, Hiroyuki Kugoh, Mitsuo Oshimura, Yuji Ito, Yasuhiro Kazuki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract We previously generated fully human antibody-producing TC-mAb mice for obtaining potential therapeutic monoclonal antibodies (mAbs). In this study, we investigated 377 clones of fully human mAbs against a tumor antigen, epithelial cell adhes
Externí odkaz:
https://doaj.org/article/fb5f52237457428e8d9321f244d2301d
Autor:
Satoshi Abe, Kazuhisa Honma, Akane Okada, Kanako Kazuki, Hiroshi Tanaka, Takeshi Endo, Kayoko Morimoto, Takashi Moriwaki, Shusei Hamamichi, Yuji Nakayama, Teruhiko Suzuki, Shoko Takehara, Mitsuo Oshimura, Yasuhiro Kazuki
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Mammalian artificial chromosomes derived from native chromosomes have been applied to biomedical research and development by generating cell sources and transchromosomic (Tc) animals. Human artificial chromosome (HAC) is a precedent chromoso
Externí odkaz:
https://doaj.org/article/980a4802a45243dab043c205122e0872
Autor:
Takashi Shinohara, Kanako Kazuki, Narumi Ogonuki, Hiroko Morimoto, Shogo Matoba, Kei Hiramatsu, Kazuhisa Honma, Teruhiko Suzuki, Takahiko Hara, Atsuo Ogura, Mitsuo Oshimura, Mito Kanatsu-Shinohara, Yasuhiro Kazuki
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1180-1191 (2017)
The introduction of megabase-sized large DNA fragments into the germline has been a difficult task. Although microcell-mediated chromosome transfer into mouse embryonic stem cells (ESCs) allows the production of transchromosomic mice, ESCs have unsta
Externí odkaz:
https://doaj.org/article/30cd4abc82c14a58823f2614f56dbfef
Autor:
Kazuhisa Honma, Satoshi Abe, Takeshi Endo, Narumi Uno, Mitsuo Oshimura, Tetsuya Ohbayashi, Yasuhiro Kazuki
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193642 (2018)
Mouse artificial chromosome (MAC) vectors have several advantages as gene delivery vectors, such as stable and independent maintenance in host cells without integration, transferability from donor cells to recipient cells via microcell-mediated chrom
Externí odkaz:
https://doaj.org/article/074d1ea039ed4277bd8a6721684c555d
Autor:
Takeshi Endo, Akane Okada, Kanako Kazuki, Yuji Nakayama, Mitsuo Oshimura, Takashi Moriwaki, Kayoko Morimoto, Teruhiko Suzuki, Shoko Takehara, Yasuhiro Kazuki, Hiroshi Tanaka, Shusei Hamamichi, Satoshi Abe, Kazuhisa Honma
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Mammalian artificial chromosomes derived from native chromosomes have been applied to biomedical research and development by generating cell sources and transchromosomic (Tc) animals. Human artificial chromosome (HAC) is a precedent chromosomal vecto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ebe1fb9ccfffe7b26ec234a84323fb4
https://pubmed.ncbi.nlm.nih.gov/34625612
https://pubmed.ncbi.nlm.nih.gov/34625612
Autor:
Takahiko Hara, Narumi Ogonuki, Shogo Matoba, Mitsuo Oshimura, Teruhiko Suzuki, Takashi Shinohara, Yasuhiro Kazuki, Hiroko Morimoto, Atsuo Ogura, Kanako Kazuki, Kazuhisa Honma, Mito Kanatsu-Shinohara, Kei Hiramatsu
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 9, Iss 4, Pp 1180-1191 (2017)
Stem Cell Reports, Vol 9, Iss 4, Pp 1180-1191 (2017)
Summary The introduction of megabase-sized large DNA fragments into the germline has been a difficult task. Although microcell-mediated chromosome transfer into mouse embryonic stem cells (ESCs) allows the production of transchromosomic mice, ESCs ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1408e61f5d188e789e46ab419cfea552
http://hdl.handle.net/2433/227222
http://hdl.handle.net/2433/227222
Autor:
Satoshi Abe, Tetsushi Sakuma, Kaoru Kobayashi, Takashi Yamamoto, Shoko Takehara, Naoto Senda, Kazuomi Nakamura, Kazuhisa Honma, Kan Chiba, Yasuhiro Kazuki, Azusa Okada, Yasuko Tsukazaki, Kanako Kazuki, Asami Oji, Mitsuo Oshimura, Masahito Ikawa
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abe, S., Kobayashi, K., Oji, A. et al. Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology. Sci Rep 7, 15189 (2017). https://doi.org/10.1038/s41598-017-15033-0
Cytochrome P450, family 3, s
Cytochrome P450, family 3, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63eafa2d0bbfc51c114b71e7459b2e25
https://pubmed.ncbi.nlm.nih.gov/29123154
https://pubmed.ncbi.nlm.nih.gov/29123154
Autor:
Mitsuhiko Osaki, Satoshi Yamazaki, Yasuhiro Kazuki, Kanako Kazuki, Tetsushi Sakuma, Mitsuo Oshimura, Shoko Takehara, Hirofumi Suemori, Hiromitsu Nakauchi, Yuwna Yakura, Naoyo Kajitani, Takashi Yamamoto, Tsutomu Toki, Satoshi Abe, Ritsuko Shimizu, Kazuhisa Honma
Publikováno v:
Scientific Reports
Infants with Down syndrome (DS) are at a high risk of developing transient abnormal myelopoiesis (TAM). A GATA1 mutation leading to the production of N-terminally truncated GATA1 (GATA1s) in early megakaryocyte/erythroid progenitors is linked to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1fc767b5126b078f4d48c22d5d5dca
https://doi.org/10.1038/srep06136
https://doi.org/10.1038/srep06136