Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kazuhiro Yumoto"'
Autor:
Hidefumi Miyata, Taiho Shuzuki, Masahiko Oshige, Miki Sasahara, Shinji Katsura, Kazuhiro Yumoto, Kanako Itoh, Hiroki Kawaura, Shunsuke Takahashi, Nobuyuki Oshima
Publikováno v:
Key Engineering Materials. 596:219-223
A method for preparing a high-density His-tagged protein array was developed. The method is based on specific binding between His-tags and Ni ions chelated with the carboxyl groups of L-cysteine applied to the substrate surface by electrodeposition.
Autor:
Shinji Katsura, Masahiko Oshige, Hiroki Kawaura, Miwa Tamegai, Shunsuke Takahashi, Kazuhiro Yumoto, Masaki Nakada, Kanako Ito, Hidefumi Miyata
Publikováno v:
Open Journal of Polymer Chemistry. :6-10
Continued advancement of protein array, bioelectrode, and biosensor technologies will necessitate development of methods that allow for increased protein immobilization capacity and more control over protein orientation. Toward these ends, we develop
Autor:
Kevin R. Shreder, Tyzoon K. Nomanbhoy, Ayako Nakamura, Anna Katrin Szardenings, Shigeki Seto, Jonathan S. Rosenblum, Brandon Leen, Oana Cociorva, Kai Nakamura, Bei Li, Marek Liyanage, John W. Kozarich, Qiang Li, Yasushi Kohno, Kazuhiro Yumoto, Kyoko Okada, Masahiro Nomura, Melissa C. Zhang, Arwin Aban
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5948-5951
The synthesis, GSK-3β inhibitory activity, and anti-microbial activity of bicyclic and tricyclic derivatives of the 5,7-diamino-6-fluoro-4-quinolone-3-carboxylic acid scaffold were studied. Kinase selectivity profiling indicated that members of this
Autor:
Tyzoon K. Nomanbhoy, Melissa C. Zhang, Kai Nakamura, Oana Cociorva, Kazuhiro Yumoto, Anna Katrin Szardenings, John W. Kozarich, Bei Li, Marek Liyanage, Yasushi Kohno, Kyoko Okada, Kevin R. Shreder, Masahiro Nomura, Qiang Li, Arwin Aban
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(2)
We previously disclosed tricylic, 6-carboxylic acid-bearing 4-quinolones as GSK-3β inhibitors. Herein we discuss the optimization of this series to yield a series of more potent 6-nitrile analogs with insignificant anti-microbial activity. Finally,
Autor:
Shigeki Isogai, Masahiro Nomura, Kazuhiro Yumoto, Yasuo Takano, Koji Murakami, Takehiro Shinozaki
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
A series of novel cyclic amine-substituted benzoic acid derivatives were synthesized and evaluated for their PPARα agonist activity. Strucure-activity relationship studies led to the identification of (S)-3-[3-[2-(4-chlorophenyl)-4-methylthyazole-5-