Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kazuhiro Tetsuka"'
Autor:
Masato Ohbuchi, Mayu Shibuta, Kazuhiro Tetsuka, Haruna Sasaki-Iwaoka, Masayo Oishi, Fumitaka Shimizu, Yasuhisa Nagasaka
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6496 (2024)
Blood–brain barrier (BBB) dysfunction is a key feature in neuroimmunological and neurodegenerative diseases. In this study, we developed a microfluidic human BBB-on-a-chip to model barrier dysfunction and immune cell migration using immortalized TY
Externí odkaz:
https://doaj.org/article/092c4504b13544d2ac8c2946f907717c
Autor:
Szczepan W, Baran, Paul C, Brown, Andreas R, Baudy, Suzanne C, Fitzpatrick, Christopher, Frantz, Aaron, Fullerton, Jinping, Gan, Rhiannon N, Hardwick, Kathleen M, Hillgren, Anna K, Kopec, Jennifer L, Liras, Donna L, Mendrick, Ryan, Nagao, William R, Proctor, Diane, Ramsden, Alexandre J S, Ribeiro, David, Stresser, Kyung E, Sung, Radhakrishna, Sura, Kazuhiro, Tetsuka, Lindsay, Tomlinson, Terry, Van Vleet, Matthew P, Wagoner, Qin, Wang, Sevim Yildiz, Arslan, Gorm, Yoder, Jason E, Ekert
Publikováno v:
ALTEX.
Complex in vitro models (CIVM) offer the potential to improve pharmaceutical clinical drug attrition due to safety and/ or efficacy concerns. For this technology to have an impact, the establishment of robust characterization and qualification plan
Autor:
Kazuhiro Tetsuka, Laura M Tool, Fumiko Kiyonaga, Marianne K. Vormann, Akira Fujimori, Masato Ohbuchi, Paul Vulto, Thomas Hankemeier, Takayuki Goto, Remko van Vught, Linda Gijzen, Henriëtte L. Lanz, Tetsuhiro Kawabe
Publikováno v:
Kidney360
Background: Renal ischemia/reperfusion injury (rIRI) is one of the major causes of acute kidney injury (AKI). While animal models are suitable for investigating systemic symptoms of AKI they are limited in translatability. Human in vitro models are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13dda44bc10390b4a5e7a95719ab5001
https://europepmc.org/articles/PMC8967632/
https://europepmc.org/articles/PMC8967632/
Autor:
Masato Ohbuchi, Kaori Takama, Shunji Yamazaki, Akira Fujimori, Kazuhiro Tetsuka, Takayuki Goto, Fumiko Kiyonaga, Tetsuhiro Kawabe
Publikováno v:
Biologicalpharmaceutical bulletin. 43(3)
Recent progress in the fields of tissue engineering, micro-electro mechanical systems, and materials science have greatly improved cell culture systems, which were traditionally performed in a static two-dimensional manner. This progress has led to a
Publikováno v:
Journal of Pharmaceutical Sciences. 106:2302-2311
Tissue engineering technology has provided many useful culture models. This article reviews the merits of this technology in a hepatocyte culture system and describes the applications of the sandwich-cultured hepatocyte model in drug discovery. In ad
Autor:
Nicolas Gerst, Mitsuyuki Matsumoto, Jack Keegan, Deyu Fang, Chris Tucker, Christopher Gallardo, Kazuhiro Tetsuka, John G. Csernansky, Janitza L. Montalvo-Ortiz, Hongxin Dong
Publikováno v:
Neuropsychopharmacology. 39:1469-1478
Antipsychotic drugs are widely prescribed to elderly patients for the treatment of a variety of psychopathological conditions, including psychosis and the behavioral disturbances associated with dementia. However, clinical experience suggests that th
Autor:
Katsuhiro Yamano, Fumihiro Nakamori, Takako Furukawa, Kazuhiro Tetsuka, Yoichi Naritomi, Kenji Tabata, Shigeyuki Terashita, Hiroyuki Moriguchi, Toshio Teramura
Publikováno v:
Xenobiotica. 44:205-216
1. Glucuronidation via UDP-glucuronosyltransferase (UGT) in the intestine has been reported to influence the pharmacokinetics (PK) of drugs; however, information concerning the differences in activity between species is limited. Here, we investigated
Autor:
Katsuhiro Yamano, Keitaro Kadono, Hiroyuki Moriguchi, Fumihiro Nakamori, Shigeyuki Terashita, Yoichi Naritomi, Toshio Teramura, Kazuhiro Tetsuka, Ken Ichi Hosoya, Takako Furukawa
Publikováno v:
Drug Metabolism and Disposition. 40:1771-1777
We investigated whether the effects of intestinal glucuronidation on the first-pass effect can be predicted from in vitro data for UDP-glucuronosyltransferase (UGT) substrates. Human in vitro intrinsic glucuronidation clearance (CL(int, UGT)) for 11
Autor:
Katsuhiro Yamano, Toshio Teramura, Kazuhiro Tetsuka, Fumihiro Nakamori, Shigeyuki Terashita, Takako Furukawa, Yoichi Naritomi, Hiroyuki Moriguchi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 27:171-180
UDP-glucuronosyltransferase (UGT) is highly expressed in the small intestine and catalyzes the glucuronidation of small molecules, which may affect the oral bioavailability of drugs. However, no method of predicting the in vivo observed fraction of a
Publikováno v:
Pharmacology Research & Perspectives
Metabolism and sinusoidal/canalicular efflux of mycophenolic acid (MPA) was investigated using sandwich-cultured hepatocytes (SCHs). After applying MPA to SCHs from humans, wild-type rats, and multidrug resistance-associated protein (Mrp) 2-deficient