Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Kazuhiro SHIIZAKI"'
Autor:
Marina Miura, Yutaka Miura, Yoshitaka Iwazu, Hideyuki Mukai, Takahiro Sugiura, Yuji Suzuki, Masami Kato, Mayumi Kano, Daisuke Nagata, Kazuhiro Shiizaki, Hiroshi Kurosu, Makoto Kuro-o
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Hyperphosphatemia is a major risk for poor prognosis in patients with end-stage renal disease. However, the molecular mechanism behind this link remains elusive. We and others have demonstrated that serum phosphorus levels correlate positive
Externí odkaz:
https://doaj.org/article/e2060f24832b44d682eb306226d61edb
Autor:
Batpurev Battulga, Kazuhiro Shiizaki, Yutaka Miura, Yasuyuki Osanai, Reiji Yamazaki, Yoshiaki Shinohara, Yoshiyuki Kubota, Toru Hara, Makoto Kuro-o, Nobuhiko Ohno
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Calcium phosphate forms particles under excessive urinary excretion of phosphate in the kidney. While the formation of calcium phosphate particles (CaPs) has been implicated in the damage to renal tubular cells and renal dysfunction, clarify
Externí odkaz:
https://doaj.org/article/fddb7b93816940fa872bab55680acdd8
Autor:
Masatomo Ogata, Shu Ushimaru, Rie Fujishima, Hirofumi Sumi, Kazuhiro Shiizaki, Naoto Tominaga
Publikováno v:
Bone Reports, Vol 17, Iss , Pp 101639- (2022)
Preventing osteoporotic fractures is an issue requiring urgent attention to reduce mortality. However, unlike chronic kidney disease-mineral and bone disorder (CKD-MBD), osteoporosis is inadequately addressed in patients undergoing chronic dialysis.
Externí odkaz:
https://doaj.org/article/ed864eff860f4e57b7e32d79780e8585
Autor:
Naoto Tominaga, Tomoki Yonaha, Masayuki Yamanouchi, Hirofumi Sumi, Yasuhiro Taki, Yugo Shibagaki, Kazuhiro Shiizaki, Shozo Yano
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Parathyroid hormone (PTH) acts on bone to indirectly increase the number and activity of osteoclasts. Thus, PTH has a stimulatory effect on bone resorption and upregulates bone turnover. However, the responsiveness of bone to PTH
Externí odkaz:
https://doaj.org/article/253c00360d3f479d950c8b97ad211326
Autor:
Yoshitaka Hirano, Hiroshi Kurosu, Kazuhiro Shiizaki, Yoshitaka Iwazu, Shuichi Tsuruoka, Makoto Kuro‐o
Publikováno v:
FEBS Open Bio, Vol 10, Iss 5, Pp 894-903 (2020)
Excessive intake of phosphate has been known to induce renal tubular damage and interstitial inflammation, leading to acute kidney injury or chronic kidney disease in rodents and humans. However, sensitive and early biomarkers for phosphate‐induced
Externí odkaz:
https://doaj.org/article/1e698dbd05864f5fa98355eb7bd94e14
Autor:
Sayoko Ito-Harashima, Mami Matano, Kana Onishi, Tomofumi Nomura, Saki Nakajima, Shingo Ebata, Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-19 (2020)
Abstract Background Sex steroid hormone receptors are classified into three classes of receptors: estrogen receptors (ER) α and β, androgen receptor (AR), and progesterone receptor (PR). They belong to the nuclear receptor superfamily and activate
Externí odkaz:
https://doaj.org/article/5523d651db03451aaa7d3d02ee185688
Autor:
Satoshi Kozawa, Ryosuke Ueda, Kyoji Urayama, Fumihiko Sagawa, Satsuki Endo, Kazuhiro Shiizaki, Hiroshi Kurosu, Glicia Maria de Almeida, Sharif M. Hasan, Kiyokazu Nakazato, Shinji Ozaki, Yoshinori Yamashita, Makoto Kuro-o, Thomas N. Sato
Publikováno v:
iScience, Vol 2, Iss , Pp 238-268 (2018)
Summary: Virtually all diseases affect multiple organs. However, our knowledge of the body-wide effects remains limited. Here, we report the body-wide transcriptome landscape across 13–23 organs of mouse models of myocardial infarction, diabetes, k
Externí odkaz:
https://doaj.org/article/40d692930b7c4ec6be5e8d98e5c5efff
Autor:
Yutaka Miura, Yoshitaka Iwazu, Kazuhiro Shiizaki, Tetsu Akimoto, Kazuhiko Kotani, Masahiko Kurabayashi, Hiroshi Kurosu, Makoto Kuro-o
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Abstract Calciprotein particles (CPP) are solid-phase calcium-phosphate bound to serum protein fetuin-A and dispersed as colloids in the blood. Recent clinical studies indicated that serum CPP levels were increased with decline of renal function and
Externí odkaz:
https://doaj.org/article/3a2096288f364f7893e361803aa224a3
Publikováno v:
Genes and Environment, Vol 39, Iss 1, Pp 1-8 (2017)
Abstract Benzo[a]pyrene (BaP) is a well-studied pro-carcinogen that is metabolically activated by cytochrome P450 enzymes. Cytochrome P4501A1 (CYP1A1) has been considered to play a central role in the activation step, which is essential for the forma
Externí odkaz:
https://doaj.org/article/2f34d4645b96478e84f6e4dbeca51250
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224613 (2019)
β-Catenin is a multi-functional protein involved in cell adhesion and signal transduction and has a critical role in colorectal cancer development. β-Catenin positively regulates the aryl-hydrocarbon receptor (AhR) mediated signal by both induction
Externí odkaz:
https://doaj.org/article/0c217d031191402e81d6822a4d5b0e34