Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.

Autor: Kazuhiro Ohmi, Hui-Zhi Zhao, Elizabeth F Neufeld

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27461 (2011)

Sanfilippo syndrome type B (MPS IIIB) is characterized by profound mental retardation in childhood, dementia and death in late adolescence; it is caused by deficiency of α-N-acetylglucosaminidase and resulting lysosomal storage of heparan sulfate. A

Externí odkaz: https://doaj.org/article/ca1182ff83834bcdbb3bb7ef938c24e2

Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells

Autor: Kazuhiro Ohmi, Xiaoqing Zhu, Allison L. Marciszyn, Kenneth R. Hallows, Dietbert Neumann, Núria M. Pastor-Soler, Fan Gong, Mohammad M. Al-bataineh, Lei Cheng, Robert A. Fenton, Sajid Naveed, Qi Wu, Hui Li

Publikováno v: American Journal of Physiology-Renal Physiology, 311(5), F890-F900. American Physiological Society
Al-Bataineh, M M, Li, H, Ohmi, K, Gong, F, Marciszyn, A, Naveed, S, Zhu, X, Neumann, D, Wu, Q, Cheng, L, Fenton, R A, Pastor-Soler, N M & Hallows, K R 2016, ' Activation of the Metabolic Sensor AMP-Activated Protein Kinase Inhibits Aquaporin-2 Function in Kidney Principal Cells ', American Journal of Physiology: Renal Physiology, pp. ajprenal.00308.2016 . https://doi.org/10.1152/ajprenal.00308.2016

Aquaporin-2 (AQP2) is essential to maintain body water homeostasis. AQP2 traffics from intracellular vesicles to the apical membrane of kidney collecting duct principal cells in response to vasopressin [arginine vasopressin (AVP)], a hormone released

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd41b944baddf2730a47b0a961d4fe8
https://doi.org/10.1152/ajprenal.00308.2016

Immunological Tolerance-Related Genes in a Spontaneous Tolerant Model of Rat Liver Transplantation Explored by Suppression Subtractive Hybridization

Autor: Akira Hirasawa, Yoshiaki Hara, Hui-qi Zhang, Kazuhiro Ohmi, Shin Enosawa, Gozoh Tsujimoto, Akihiko Tamura

Publikováno v: Cell Transplantation, Vol 17 (2008)

Natural immunological tolerance can be induced in certain types of allogeneic liver transplantation in rats. To screen for genes associated with the induction of tolerance, suppression subtractive hybridization was performed in the rat liver transpla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed881cfea3e9e9ee9bb7a13bd543222
https://doi.org/10.3727/000000008783906955

Brap2 Functions as a Cytoplasmic Retention Protein for p21 during Monocyte Differentiation

Autor: Hidenori Suzuki, Shin Enosawa, Seiichi Suzuki, Shuki Mizutani, Minoru Asada, Kazuhiro Ohmi, Domenico Delia, Akira Yuo

Publikováno v: Molecular and Cellular Biology. 24:8236-8243

The cell cycle inhibitor p21 plays an important role in monocytic cell differentiation, during which it translocates from the nucleus to cytoplasm. This process involves the negative regulation of the p21 nuclear localization signal (NLS). Here, we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7636c6bd3a7844b9424564e16d41a0f
https://doi.org/10.1128/mcb.24.18.8236-8243.2004

Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB

Autor: Shih-hsin Kan, Zhi Chen, Stuart Bunting, Brett E. Crawford, Wesley Wong, Anil Bagri, Evan G. Adintori, John Holtzinger, Melanie J. Lo, Elizabeth F. Neufeld, Danielle Crippen-Harmon, Paul A. Fitzpatrick, Jillian R. Brown, Josh C. Woloszynek, Pascale M.N. Tiger, Kristen N. Vondrak, Diana S. Cheung, Kazuhiro Ohmi, Jon Vincelette, Sherry Bullens, Jonathan H. LeBowitz, Chuck Hague, Steven Q. Le, Roger Lawrence, Terri Christianson, Bryan K. Yip, Daniel J. Wendt, Katherine A. Webster, Mika Aoyagi-Scharber, Patricia I. Dickson

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 41

Mucopolysaccharidosis type IIIB (MPS IIIB, Sanfilippo syndrome type B) is a lysosomal storage disease characterized by profound intellectual disability, dementia, and a lifespan of about two decades. The cause is mutation in the gene encoding α–N-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e9cef317d3d7e5f182f493e8a4dd4c
https://europepmc.org/articles/PMC4205671/