Zobrazeno 1 - 10
of 806
pro vyhledávání: '"Kazuhiro NAKAMURA"'
Publikováno v:
IBRO Neuroscience Reports, Vol 16, Iss , Pp 345-352 (2024)
Spinal cord injury (SCI) is a devastating mechanical trauma. Although locomotion of model animals that mimic contusion SCI was actively examined, locomotion after penetrating SCI caused by sharp objects was not extensively studied. Severity of walkin
Externí odkaz:
https://doaj.org/article/5897a04e2a214ed79693eea006ef58db
Autor:
Ayaka Mori, Taichi Shiroishi, Jun Fujioka, Takashi Nakajima, Shinichi Mitsui, Hinaho Suginoma, Yohei Kakuta, Heishun Zen, Kazuhiro Nakamura
Publikováno v:
Brain Disorders, Vol 14, Iss , Pp 100137- (2024)
Polyglutamine (polyQ) diseases are devastating neurological disorders that cannot be effectively treated. Repeat-associated non-AUG (RAN) translation has been documented in transcripts in polyQ diseases. RAN products include proteins with polyleucine
Externí odkaz:
https://doaj.org/article/32edc9fcff4845b0a59e4b09fc69181b
Autor:
Akinari Yamano, MD, Kiyoyuki Yanaka, MD, PhD, Kuniyuki Onuma, MD, Kazuhiro Nakamura, MD, PhD, Nobuyuki Takahashi, MD, PhD, Hidehiro Kohzuki, MD, PhD, Noriaki Sakamoto, MD, PhD, Masahide Matsuda, MD, PhD, Eiichi Ishikawa, MD, PhD
Publikováno v:
Radiology Case Reports, Vol 18, Iss 10, Pp 3448-3452 (2023)
Perilesional T1 hyperintensity on magnetic resonance imaging (MRI) of intra-axial brain masses is an unusual feature of the perilesional area, characteristic of cavernous malformations (CMs) and metastatic brain tumors (METs). Here, we report a case
Externí odkaz:
https://doaj.org/article/8b8ea073a5c842a091c91d2a93e5ff8d
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0296750 (2024)
Whether fibril formation increases or decreases cytotoxicity remains unclear. Aggregation of human islet amyloid polypeptide (hIAPP), a pivotal regulator of glucose homeostasis, impairs the function and viability of pancreatic β cells. Evidence sugg
Externí odkaz:
https://doaj.org/article/8159ac3aaa224a3fa4e372cacee00dba
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Repeat-associated non-AUG translation (RAN translation) is observed in transcripts that are causative for polyglutamine (polyQ) diseases and generates proteins with mono amino acid tracts such as polyalanine (polyA), polyleucine (polyL) and
Externí odkaz:
https://doaj.org/article/ce0e1912bc514b9b93b69a53b8de9328
Publikováno v:
Journal of Synchrotron Radiation, Vol 29, Iss 5, Pp 1133-1140 (2022)
Amyloidosis is known to be caused by the deposition of amyloid fibrils into various biological tissues; effective treatments for the disease are little established today. An infrared free-electron laser (IR-FEL) is an accelerator-based picosecond-pul
Externí odkaz:
https://doaj.org/article/9c749a2b15324e78a01820e8d8d94cfa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Functional brain architecture underlying autonomic adjustments to exercise has remained unknown. Here, the authors reveal a subcortical pathway that relays volitional motor signals to drive locomotor activities and sympathetic cardiovascular response
Externí odkaz:
https://doaj.org/article/d9bef4304cbb4c67b4964bdf59f02198
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Repeat-associated non-AUG (RAN) translation of mRNAs/transcripts responsible for polyglutamine (polyQ) diseases may generate peptides containing different mono amino acid tracts such as polyserine (polyS) and polyleucine (polyL). The propaga
Externí odkaz:
https://doaj.org/article/70ca2cb6191449d3b736281cac076c5a
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291093 (2023)
Polyalanine (polyA) disease-causative proteins with an expansion of alanine repeats can be aggregated. Although curative treatments for polyA diseases have not been explored, the dissociation of polyA aggregates likely reduces the cytotoxicity of pol
Externí odkaz:
https://doaj.org/article/1c9cc8c341c848ad9127bd8ad0b83a9a
Autor:
Yutaro Iizuka, Ryuji Owada, Takayasu Kawasaki, Fumio Hayashi, Masashi Sonoyama, Kazuhiro Nakamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract In polyalanine (PA) diseases, the disease-causing transcription factors contain an expansion of alanine repeats. While aggregated proteins that are responsible for the pathogenesis of neurodegenerative disorders show cell-to-cell propagation
Externí odkaz:
https://doaj.org/article/23d0c4209bfd4d6888037625305ffe9f