Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kazuhiro Kuga"'
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2021)
Subarachnoid hemorrhage (SAH) is a life-threatening condition that can also lead to permanent paralysis. However, the mechanisms that underlying neurobehavioral deficits after SAH have not been fully elucidated. As theta burst stimulation (TBS) can i
Externí odkaz:
https://doaj.org/article/2391f0873e0f4a6a84d90aa514ecb5fb
Autor:
Kazuhiro Kuga, Yoichiro Kusakari, Ken Uesugi, Kentaro Semba, Takashi Urashima, Toru Akaike, Susumu Minamisawa
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231905 (2020)
Myocardial fibrosis is often associated with cardiac hypertrophy; indeed, fibrosis is one of the most critical factors affecting prognosis. We aimed to identify the molecules involved in promoting fibrosis under hypertrophic stimuli. We previously es
Externí odkaz:
https://doaj.org/article/e064458f725645a9aba63650a369a1ce
Autor:
Kazuhiro Kuga1 kazuhiro.kuga@takeda.com, Motohiro Shiotani2, Kentaro Hori3, Hiroshi Mizuno4, Yusaku Matsushita4, Harushige Ozaki1, Kohei Hayashi3, Takatomi Kubo5, Manabu Kano6
Publikováno v:
Journal of Toxicological Sciences. 2024, Vol. 49 Issue 5, p231-240. 10p.
Autor:
Qin, Wang, Jennifer D, Cohen, Tomoya, Yukawa, Heather, Estrella, Chris, Leonard, Jairo, Nunes, Colin, Choi, Lauren, Lewis, Kevin S, Baker, Kazuhiro, Kuga, Yvonne P, Dragan, Matthew P, Wagoner, Nibha, Mishra
Publikováno v:
ALTEX.
Drug-induced neurotoxicity is a leading cause of safety-related attrition for therapeutics in clinical trials, often driven by poor predictivity of preclinical in vitro and in vivo models of neurotoxicity. Over a dozen different iPSC-derived 3D spher
Drug-induced convulsions-often caused by the inhibition of GABA receptors and stimulation of glutamate receptors-are difficult to predict in animals. In this study, we attempted to detect the proconvulsant potential using motor-evoked potentials (MEP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19084e21515d4db45d9fbb719591dbe6
Publikováno v:
Journal of pharmacological and toxicological methods. 112
Drug-induced convulsion is a severe adverse event; however, no useful biomarkers for it have been discovered. We propose a new method for predicting drug-induced convulsions in monkeys based on heart rate variability (HRV) and a machine learning tech
Autor:
Masako Kiyono, Kohji Nishimura, Yusuke Deromachi, Shimpei Uraguchi, Masa H. Sato, Tomoko Hirano, Kazuhiro Kuga
Publikováno v:
Plant Signal Behav
Acute and chronic arsenic (As) toxicity is a global health issue affecting millions of people, which leads to inactivation of over 200 enzymes, particularly those involved in cellular energy pathways and DNA synthesis and repair. The fern Pteris vitt
Autor:
Toru Akaike, Susumu Minamisawa, Yoichiro Kusakari, Ken Uesugi, Kazuhiro Kuga, Takashi Urashima, Kentaro Semba
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231905 (2020)
PLoS ONE
PLoS ONE
Myocardial fibrosis is often associated with cardiac hypertrophy; indeed, fibrosis is one of the most critical factors affecting prognosis. We aimed to identify the molecules involved in promoting fibrosis under hypertrophic stimuli. We previously es
Autor:
Hironobu Yasuno, Yuki Takamatsu, Makoto Miyamoto, Kazuhiro Kuga, Yumiko Harada, Yumiko Miyamoto, Keiichiro Sato, Yumi Sakai, Fumi Shimizu
Publikováno v:
Journal of pharmacological and toxicological methods. 88(Pt 1)
In vivo phototoxicity studies are important to predict drug-induced phototoxicity in humans; however, a standard methodology has not established. To determine differences in sensitivity to drug-induced phototoxicity among various skin sites, we evalu