Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kazuhiro Kose"'
Autor:
Kazue Uchida, Kazuhiro Kose, Shinji Tanaka, Tomoko Kawaguchi, Takaaki Hiragun, Yuhki Yanase, Michihiro Hide
Publikováno v:
Biosensors & Bioelectronics. 32(1):202-207
Surface plasmon resonance (SPR) biosensor detects intracellular signaling events as a change of the angle of resonance (AR). We previously reported that the activation of epidermal growth factor receptor (EGFR) on keratinocytes causes a unique tripha
Publikováno v:
Journal of Gastroenterology and Hepatology. 20:1679-1684
Background: Somatic mutations of mitochondrial DNA (mtDNA) have been reported to play an important role in the carcinogenesis of several human cancers. However, there are few reports on mtDNA mutations in digestive tract cancers, including esophageal
Autor:
Kazuhiro Kose, Handan Tuncel, Ken Haruma, Shogo Sasao, Yasuhiko Kitadai, Shinji Tanaka, Yoshitaka Ueno, Hideyuki Shima, Kazuaki Chayama, Toru Hiyama, Wataru Yasui, Masanori Ito, Masaharu Yoshihara
Publikováno v:
Journal of Gastroenterology and Hepatology. 19:756-760
Background: Gastric cancer can progress through two pathways of genomic instability: chromosomal (CIN) and microsatellite instability (MSI). It is hypothesized that these two pathways are not always independent and that some tumors show overlap betwe
Autor:
Masanori Ito, Handan Tuncel, Fumio Shimamoto, Masaharu Sumii, Kazuaki Chayama, Shinji Tanaka, Hideyuki Shima, Ken Haruma, Kazuhiro Kose, Yasuhiko Kitadai, Hiroshi Masuda, Toru Hiyama, Masaharu Yoshihara, Naomi Uemura
Publikováno v:
Journal of Gastroenterology and Hepatology. 18:1202-1207
Background and Aims: Resistance to antibiotics in Helicobacter pylori is increasing and becoming a serious problem in eradication treatment of H. pylori. The prevalence of H. pylori infections that are resistant to clarithromycin, metronidazole, or b
Publikováno v:
Pathobiology : journal of immunopathology, molecular and cellular biology. 73(2)
Objective: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Nuclear (nMSI) and mitochondrial microsatellite instability (mtMSI) play important roles in tumorigenesis in various organs. The aim of
Autor:
Ken Haruma, Hideyuki Shima, Shinji Tanaka, Kazuhiro Kose, Toru Hiyama, Masanori Ito, Handan Tuncel, Yasuhiko Kitadai, Fumio Shimamoto, Masaharu Yoshihara, Kazuaki Chayama, Masaharu Sumii
Publikováno v:
Oncology reports. 10(6)
It was reported that somatic mutations in the mitochondrial DNA (mtDNA) are associated with high-frequency microsatellite instability (MSI-H) of the nuclear in gastric cancers. However, no correlation between mtDNA mutations and nuclear MSI-H was fou
Autor:
Fumio Shimamoto, Hiroshi Masuda, Kazuhiro Kose, Masaharu Sumii, Hideyuki Shima, Ken Haruma, Kazuaki Chayama, Handan Tuncel, Naomi Uemura, Shinji Tanaka, Toru Hiyama, Yasuhiko Kitadai, Masanori Ito, Masaharu Yoshihara
Publikováno v:
Journal of gastroenterology and hepatology. 18(9)
Background and Aims: Genetic mechanisms involved in the development of gastric B-cell lymphomas remain unclear. The aim of the present study was to clarify the roles of mutations of the p53 and K-ras genes, and microsatellite instability (MSI) in the
Autor:
Masaharu Sumii, Kazuhiro Kose, Masanori Ito, Yasuhiko Kitadai, Fumio Shimamoto, Masaharu Yoshihara, Kazuaki Chayama, Toru Hiyama, Shinji Tanaka, Ken Haruma, Hideyuki Shima
Publikováno v:
International Journal of Molecular Medicine.
Somatic mutations of the mitochondrial DNA (mtDNA) are associated with development of various types of human cancer. To elucidate the significance of somatic mutations of the mtDNA in gastric carcinogenesis, we examined mtDNA mutations in gastric can
Autor:
Masaharu Yoshihara, Masaharu Sumii, Kazuaki Chayama, Masanori Ito, Kazuhiro Kose, Hideyuki Shima, Ken Haruma, Shinji Tanaka, Yasuhiko Kitadai, Toru Hiyama, Fumio Shimamoto
Publikováno v:
Oncology reports. 10(5)
Previous studies suggest that a telomerase repressor/senescence gene, which acts as a tumor suppressor gene, may be located on chromosome 10p15. However, there are no studies on alterations on chromosome 10p15 in gastric cancers. We, therefore, exami
Autor:
Takehiko Ochiumi, Kazuhiro Kose, Takehiro Ueda, Shinji Tanaka, Masanori Ito, Ken Haruma, Shogo Sasao, Yasuhiko Kitadai, Kazuaki Chayama, Tadamasa Tamura, Masaharu Sumii, Toru Hiyama, Ryoji Takahashi, Shiro Oka, Shinji Nagata, Eijiro Kaio
Publikováno v:
Gastroenterology. 124:A653