Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kazuhiro Kosakai"'
Autor:
Kazuhiro Ikegai, Takeshi Murakami, Yasufumi Ohkura, Yoshinori Kobayashi, Makoto Takeuchi, Ryota Shiraki, Takashi Ogiyama, Hiroshi Tomiyama, Atsushi Noda, Masakazu Imamura, Masayuki Yokota, Eiji Kurosaki, Kazuhiro Kosakai, Keita Nakanishi, Tomokazu Koide, Mitsuaki Ohta, Takayuki Suzuki
Publikováno v:
Bioorganicmedicinal chemistry. 20(10)
A series of C-glucosides with various heteroaromatics has been synthesized and its inhibitory activity toward SGLTs was evaluated. Upon screening several compounds, the benzothiophene derivative (14a) was found to have potent inhibitory activity agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427aab19d695a71f7869680d9ace5a71
https://pubmed.ncbi.nlm.nih.gov/22507206
https://pubmed.ncbi.nlm.nih.gov/22507206
Publikováno v:
European Journal of Pharmacology. 251:1-7
In rat aorta, KT2-734 inhibited contractile responses to 5-hydroxytryptamine (5-HT) and KCl. KT2-734 inhibited the relaxing effect of verapamil, but not nifedipine. Similarly, verapamil, but not nifedipine, inhibited the vasorelaxing effect of KT2-73
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94be043e86296c4b309991f00c896aed
https://doi.org/10.1016/0014-2999(94)90435-9
https://doi.org/10.1016/0014-2999(94)90435-9
Autor:
Satoko Uchibori, Kazuhiro Kosakai, Kenji Imamaki, Tsuyoshi Tomiyama, Masahiro Kondo, Masayuki Yokota
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1687-1692
Modification of sulfonamide moiety in non-prostanoid thromboxane A 2 (TXA 2 ) receptor antagonist, KT2-962 with double amide, sulfonamide-amide, (thio)semicarbazone, inverse sulfonamide and N-sulfonylcarboxamide is described. Unlike prostanoid TXA 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50d84ffc4a48eefb5f6b57873278bbab
https://doi.org/10.1016/s0960-894x(00)80043-8
https://doi.org/10.1016/s0960-894x(00)80043-8
Autor:
Nobuhiro Satake, Shuichi Wakabayashi, Seiichiro Mochizuki, Akira Tomiyama, Tomoe Sato, Shoji Shibata, Qin Zhou, Kazuhiro Kosakai
Publikováno v:
Journal of Cardiovascular Pharmacology. 21:441-447
Pharmacologic properties of KT2-962 (6-isopropyl-3-[4-(p-chlorobenzenesulfonylamino)butyl]-azulene+ ++-1-sulfonic acid sodium salt, KT) were studied in isolated rat aorta, rat tail artery, rabbit aorta, rabbit renal artery, and pig coronary artery. K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7190599ba1c3297f94ad40eabb7e2f2
https://doi.org/10.1097/00005344-199303000-00014
https://doi.org/10.1097/00005344-199303000-00014
Publikováno v:
Chemical and Pharmaceutical Bulletin. 39:2429-2432
The metabolites of sodium 3-ethyl-7-isopropyl-1-azulenesulfonate (KT1-32, 1), a candidate as an anti-ulcer drug, and related compounds were synthesized. The effects of the compounds on anti-peptic activity were determined as compared to that of 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f268bf9c051851d3107a138fe545d3
https://doi.org/10.1248/cpb.39.2429
https://doi.org/10.1248/cpb.39.2429
Publikováno v:
Journal of Medicinal Chemistry. 33:2323-2326
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e00a69ff4a78173cf29ca5c91d7a10c
https://doi.org/10.1021/jm00171a004
https://doi.org/10.1021/jm00171a004
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:3355-3358
A series of alkylazulene-1-sodium sulfonate derivatives which has an isopropyl group at 6-position were synthesized, and their anti-ulcer activities were examined in Shay pylorus-ligated rats. The values of lipophilicity (log P) as a parameter of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c35a42793396a206092019fbb08d6c
https://doi.org/10.1248/cpb.38.3355
https://doi.org/10.1248/cpb.38.3355
Autor:
Seiichiro Mochizuki, Masaaki Kashima, Hitomi Sekiguchi, Shuichi Wakabayashi, Kazuhiro Kosakai, Akira Tomiyama
Publikováno v:
Folia Pharmacologica Japonica. 96:185-204
Azuletil sodium (AZE, 100 mg/kg, p.o.) did not affect the general behaviors, spontaneous motor activity, pentobarbital-induced hypnosis and body temperature. Furthermore, it did not elicit anticonvulsant and muscle relaxant actions. However, AZE (300
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b06ae2ff98bd0767e5f51e6d54bbfed
https://doi.org/10.1254/fpj.96.4_185
https://doi.org/10.1254/fpj.96.4_185
Autor:
Satoko Uchibori, Rei Koyama, Masayuki Yokota, Shuichi Wakabayashi, Kazuhiro Kosakai, Hayashi Hiromi, Tsuyoshi Tomiyama
Publikováno v:
Bioorganicmedicinal chemistry. 4(4)
In order to examine the correlation between activity and hydrophilicity of the side chain of sodium 3-[4-(4-chlorobenzenesulfonylamino)butyl]-6-isopropylazulene -1-sulfonate (KT2-962), a non-prostanoid TXA2/PGH2 receptor antagonist, one or two hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717c2b88c1749b4e2e1f195d35763e32
https://pubmed.ncbi.nlm.nih.gov/8735846
https://pubmed.ncbi.nlm.nih.gov/8735846
Autor:
Tomoe Sato, Chika Fukai, Kazuya Furuta, Kenji Hase, Shuichi Wakabayashi, Yasufumi Ohkura, Akira Tomiyama, Kazuhiro Kosakai, Seiichiro Mochizuki
Publikováno v:
Journal of cardiovascular pharmacology. 25(1)
We examined pharmacological profiles of KT3-671, 2-propyl-8-oxo-1-[(2'-(1H-tetrazole-5-yl) biphenyl-4-yl)methyl]- 4,5,6,7-tetrahydro-cycloheptimidazole, a newly synthesized nonpeptide angiotensin II (AII) receptor antagonist in various in vitro and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17f838ccd48f2e9856b72089bc305c5
https://pubmed.ncbi.nlm.nih.gov/7723348
https://pubmed.ncbi.nlm.nih.gov/7723348