Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Kazuhiro Kohama"'
Autor:
Hideyuki Tanaka, Hong-Hui Wang, Sean E. Thatcher, Haruo Hagiwara, Hiromi Takano-Ohmuro, Kazuhiro Kohama
Publikováno v:
Journal of Pharmacological Sciences, Vol 128, Iss 2, Pp 78-82 (2015)
The role of myosin light chain kinase (MLCK) in inducing podosomes was examined by confocal and electron microscopy. Removal of myosin from the actin core of podosomes using blebbistatin, a myosin inhibitor, resulted in the formation of smaller podos
Externí odkaz:
https://doaj.org/article/12b5190e7371490d9e8a48dae6166a97
Autor:
Hong Hui Wang, Akio Nakamura, Shinji Yoshiyama, Ryoki Ishikawa, Na Cai, Li-Hong Ye, Hiromi Takano-Ohmuro, Kazuhiro Kohama
Publikováno v:
Journal of Pharmacological Sciences, Vol 119, Iss 1, Pp 91-96 (2012)
Myosin light-chain kinase (MLCK) is a multi-domain protein with kinase and actin-binding domains, among others. Deficiency of MLCK expression in GBaSM-4 vascular smooth muscle cells enhanced cell proliferation rate and shortened cell doubling time. T
Externí odkaz:
https://doaj.org/article/3e7bfed33d634dfd82c5dd249dd9e7fb
Autor:
Sean E. Thatcher, Mike E. Fultz, Hideyuki Tanaka, Haruo Hagiwara, Hou-Li Zhang, Ying Zhang, Kohichi Hayakawa, Shinji Yoshiyama, Akio Nakamura, Hong Hui Wang, Takeshi Katayama, Masaru Watanabe, Yuan Lin, Gary L. Wright, Kazuhiro Kohama
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 1, Pp 116-127 (2011)
Abstract.: Previous work has suggested that in addition to its kinase activity, myosin light chain kinase (MLCK) exhibits non-kinase properties within its N-terminus that could influence cytoskeletal organization of smooth muscle cells (A. Nakamura e
Externí odkaz:
https://doaj.org/article/3e9da05155d74a178f41b97c8c271147
Autor:
Shinji Yoshiyama, Takahiro Horinouchi, Soichi Miwa, Hong Hui Wang, Kazuhiro Kohama, Akio Nakamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 115, Iss 4, Pp 532-535 (2011)
Cigarette smoking is one of the factors causing accumulation of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques. Changes in cell migration toward platelet-derived growth factor BB were investigated using a Boyden chamber after 48-h pr
Externí odkaz:
https://doaj.org/article/7ed2231c9c1d449eaa12045f1e82ab19
Autor:
Ryoki Ishikawa, Kazuhiro Kohama
Publikováno v:
Journal of Pharmacological Sciences, Vol 105, Iss 1, Pp 6-11 (2007)
The motility of the growth cone, an intracellular apparatus located at the tip of the axon in developing neurons, is thought to govern axonal path-finding and the construction of neuronal networks. Growth cones contain an actin-rich cytoskeleton, and
Externí odkaz:
https://doaj.org/article/f12b184bb71e4a34a37ed64eafe9e554
Autor:
Takeshi Katayama, Shinji Yoshiyama, Hideyuki Tanaka, Hong Hui Wang, Akio Nakamura, Kazuhiro Kohama
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 3, Pp 339-342 (2006)
We prepared a cell-populated collagen-gel fiber including GbaSM-4 cells derived from the basilar artery of guinea pigs. This fiber tended to be a differentiated contractile phenotype in electron-microscope observations. Sphingosylphosphorylcholine (S
Externí odkaz:
https://doaj.org/article/85504e0c621d40f6aa484287a8ae237b
Autor:
Sheng Li, Tiejun Zhao, Hong Xin, Li-Hong Ye, Xiaodong Zhang, Hideyuki Tanaka, Akio Nakamura, Kazuhiro Kohama
Publikováno v:
Journal of Pharmacological Sciences, Vol 94, Iss 3, Pp 334-338 (2004)
GbaSM-4 cells, vascular smooth muscle cells (VSMCs) derived from brain basilar arteries, were shown to migrate toward d-nicotine by augmenting the actin cytoskeleton in their cell bodies and lamellipodia, and expression of nicotinic acetylcholine rec
Externí odkaz:
https://doaj.org/article/78a5b481f27843b2b6df7a9a8db1758d
Autor:
Kazuyuki Sakamoto, Masatoshi Hori, Masanori Izumi, Tatsuya Oka, Kazuhiro Kohama, Hiroshi Ozaki, Hideaki Karaki
Publikováno v:
Journal of Pharmacological Sciences, Vol 92, Iss 1, Pp 56-69 (2003)
In the isolated rat aorta, a ROCKs (rhoA-dependent coiled coil serine/threonine kinases) inhibitor, Y-27632, inhibited the contractions induced not only by receptor agonists but also by high K+ with the similar IC50 values (0.8 – 4.9 μM). However,
Externí odkaz:
https://doaj.org/article/aaec22a9713f4492847e9318af98f961
Autor:
Hideyuki Tanaka, Gary L. Wright, Kazuhiro Kohama, Lisa A. Cassis, Mike E. Fultz, Jason Edward Black, Sean E. Thatcher
Publikováno v:
Journal of cardiobiology
Aim The purpose of the study was to localize matrix metalloproteinase (MMP)-14, -9, and -2 in the A7r5 smooth muscle cell and to understand the interaction between these MMPs and the cytoskeleton. This interaction was observed under non-stimulating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda495174039f861658018d32a1abdba
https://doi.org/10.13188/2332-3671.1000020
https://doi.org/10.13188/2332-3671.1000020
Autor:
Ying Zhao, Weifeng Mao, Lingmin Pan, Xiaoqing Wei, Fushun Fan, Yunliang Sun, Fang Li, Ying Gao, Kazuhiro Kohama, Ying Cui, Yuanhua Qin
Publikováno v:
Immunopharmacology and immunotoxicology. 41(3)
Context: Atherosclerosis is a chronic inflammatory disease in which the plaques were built up inside of the artery. Interleukin-8 (IL-8, CXCL8) is an inflammatory factor, known to play an important...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c079bc866b9aa9f885429717a87fbaf
https://pubmed.ncbi.nlm.nih.gov/31124391
https://pubmed.ncbi.nlm.nih.gov/31124391