Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kazuhiro Fukumura"'
Autor:
Kazuhiro Fukumura, Rei Yoshimoto, Luca Sperotto, Hyun-Seo Kang, Tetsuro Hirose, Kunio Inoue, Michael Sattler, Akila Mayeda
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The length distribution of human pre-mRNA introns is very extensive. The authors demonstrate that splicing in a subset of short introns is dependent on SPF45 (RBM17), which replaces authentic U2AF-heterodimer on the truncated poly-pyrimidine tracts a
Externí odkaz:
https://doaj.org/article/9ab44e7770a74812b0cfe956d0384151
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to var
Externí odkaz:
https://doaj.org/article/96b50050e32241f9accc7addc7851d82
Autor:
Shintaro Muraoka, Kazuhiro Fukumura, Megumi Hayashi, Naoyuki Kataoka, Akila Mayeda, Daisuke Kaida
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8799 (2020)
Pre-mRNA splicing is an essential mechanism for ensuring integrity of the transcriptome in eukaryotes. Therefore, splicing deficiency might cause a decrease in functional proteins and the production of nonfunctional, aberrant proteins. To prevent the
Externí odkaz:
https://doaj.org/article/7ce2ba30f696457f8f8165138383d9c2
Autor:
Kazuhiro Fukumura, Shunichi Wakabayashi, Naoyuki Kataoka, Hiroshi Sakamoto, Yutaka Suzuki, Kenta Nakai, Akila Mayeda, Kunio Inoue
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 8, p 1153 (2016)
The exon junction complex (EJC) that is deposited onto spliced mRNAs upstream of exon–exon junctions plays important roles in multiple post-splicing gene expression events, such as mRNA export, surveillance, localization, and translation. However,
Externí odkaz:
https://doaj.org/article/79cf3a8841124e69b2b290ac0a1e8386
Autor:
Hiroaki Nagamine, Masakazu Yashiro, Naoki Yoshimoto, Motohiro Izumi, Akira Sugimoto, Kenji Nakahama, Koichi Ogawa, Yoshiya Matsumoto, Kenji Sawa, Yoko Tani, Hiroyasu Kaneda, Shigeki Mitsuoka, Kazuhiro Yamada, Tetsuya Watanabe, Kazuhisa Aasai, Kazuhiro Fukumura, Akila Mayeda, Tomoya Kawaguchi
Immune checkpoint inhibitors (ICIs) are currently a standard treatment tool for non-small cell lung cancer (NSCLC). RNA-binding motif protein 17 (RBM17), a splicing factor,is frequently overexpressed in NSCLC, but little is known about the role of RB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::875e950ee76c3c48e39f2b01b910abaf
https://doi.org/10.21203/rs.3.rs-2603216/v1
https://doi.org/10.21203/rs.3.rs-2603216/v1
Autor:
Kazuhiro Fukumura, Luca Sperotto, Stefanie Seuß, Hyun-Seo Kang, Rei Yoshimoto, Michael Sattler, Akila Mayeda
SUMMARYHuman pre-mRNA splicing requires the removal of introns with highly variable lengths, from tens to over a million nucleotides. Therefore, mechanisms of intron recognition and splicing are likely not universal. Recently, we reported that splici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc3d7c830b27ee1355e6e8fdd96b90a0
https://doi.org/10.1101/2022.12.30.522300
https://doi.org/10.1101/2022.12.30.522300
Autor:
Hisamori Kato, Kazuhiro Fukumura, Naohiko Koshikawa, Akila Mayeda, Yohei Miyagi, Motoharu Seiki, Hoshino Daisuke
Publikováno v:
Cancer Science
Laminins are heterotrimeric ECM proteins composed of α, β, and γ chains. The γ2 chain (Lm‐γ2) is a frequently expressed monomer and its expression is closely associated with cancer progression. Laminin‐γ2 contains an epidermal growth factor
Publikováno v:
Mol Cell Oncol
The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to var
Autor:
Hyun-Seo Kang, Michael Sattler, Kazuhiro Fukumura, Luca Sperotto, Kunio Inoue, Tetsuro Hirose, Rei Yoshimoto, Akila Mayeda
Human pre-mRNA introns vary in size from under fifty to over a million nucleotides. We searched for essential factors specifically involved in the splicing of human short introns by screening siRNAs against 154 human nuclear proteins for activity on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81de21f87524bde91ca3a87f4819db53
https://doi.org/10.21203/rs.3.rs-75309/v1
https://doi.org/10.21203/rs.3.rs-75309/v1
Publikováno v:
Biochemical and Biophysical Research Communications. 496:921-926
Human RNPS1 protein was first identified as a pre-mRNA splicing activator in vitro and RNPS1 regulates alternative splicing in cellulo. RNPS1 was also known as a peripheral factor of the exon junction complex (EJC). Here we show that cellular knockdo