Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Kazuhiro Aiba"'
Autor:
Kazuya Goto, Keiko Imamura, Kenichi Komatsu, Kohnosuke Mitani, Kazuhiro Aiba, Norio Nakatsuji, Makoto Inoue, Akihiro Kawata, Hirofumi Yamashita, Ryosuke Takahashi, Haruhisa Inoue
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 115-125 (2017)
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal degenerative disorder of motor neurons (MNs). Embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs) now help us to understand the pathomechanisms of ALS via disease modeling.
Externí odkaz:
https://doaj.org/article/840ec00a4bc249e89f446490b62d017e
Publikováno v:
Stem Cell Research, Vol 15, Iss 3, Pp 459-468 (2015)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative motor neuron (MN) disease. The gene encoding superoxide dismutase 1 (SOD1) is a causative element of familial ALS. Animal ALS models involving SOD1 gene mutations are widely used to study the
Externí odkaz:
https://doaj.org/article/ba2d34ad718e45ecb6987969f3f80ef8
Autor:
Tomomi G. Otsuji, Jiang Bin, Azumi Yoshimura, Misayo Tomura, Daiki Tateyama, Itsunari Minami, Yoshihiro Yoshikawa, Kazuhiro Aiba, John E. Heuser, Taito Nishino, Kouichi Hasegawa, Norio Nakatsuji
Publikováno v:
Stem Cell Reports, Vol 2, Iss 5, Pp 734-745 (2014)
Utilizing human pluripotent stem cells (hPSCs) in cell-based therapy and drug discovery requires large-scale cell production. However, scaling up conventional adherent cultures presents challenges of maintaining a uniform high quality at low cost. In
Externí odkaz:
https://doaj.org/article/a7da3ee2651749578143de9250850ca9
Autor:
Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi
Publikováno v:
Cell Reports, Vol 6, Iss 6, Pp 1165-1174 (2014)
A small-molecule fluorescent probe specific for human pluripotent stem cells would serve as a useful tool for basic cell biology research and stem cell therapy. Screening of fluorescent chemical libraries with human induced pluripotent stem cells (iP
Externí odkaz:
https://doaj.org/article/1c3d5d49919f4f0da81b696fd5dbdc2c
Autor:
Itsunari Minami, Kohei Yamada, Tomomi G. Otsuji, Takuya Yamamoto, Yan Shen, Shinya Otsuka, Shin Kadota, Nobuhiro Morone, Maneesha Barve, Yasuyuki Asai, Tatyana Tenkova-Heuser, John E. Heuser, Motonari Uesugi, Kazuhiro Aiba, Norio Nakatsuji
Publikováno v:
Cell Reports, Vol 2, Iss 5, Pp 1448-1460 (2012)
Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem cells, are potentially useful in regenerative therapies for heart disease. For medical applications, clinical-grade cardiac cells must be produced from
Externí odkaz:
https://doaj.org/article/6308896a15144f35836539ec46846f5f
Publikováno v:
The Proceedings of the Fluids engineering conference. 2022:OS09-02
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19f13b272ad4f2ef98f6410eaa68e023
https://doi.org/10.1299/jsmefed.2022.os09-02
https://doi.org/10.1299/jsmefed.2022.os09-02
Autor:
Tamaki Wada, Makoto Honda, Itsunari Minami, Norie Tooi, Yuji Amagai, Norio Nakatsuji, Kazuhiro Aiba
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6722 (2009)
BACKGROUND: There are no cures or efficacious treatments for severe motor neuron diseases. It is extremely difficult to obtain naïve spinal motor neurons (sMNs) from human tissues for research due to both technical and ethical reasons. Human embryon
Externí odkaz:
https://doaj.org/article/19c849171a484cecafc9dffbc91342ee
Autor:
Alexei A Sharov, Yulan Piao, Ryo Matoba, Dawood B Dudekula, Yong Qian, Vincent VanBuren, Geppino Falco, Patrick R Martin, Carole A Stagg, Uwem C Bassey, Yuxia Wang, Mark G Carter, Toshio Hamatani, Kazuhiro Aiba, Hidenori Akutsu, Lioudmila Sharova, Tetsuya S Tanaka, Wendy L Kimber, Toshiyuki Yoshikawa, Saied A Jaradat, Serafino Pantano, Ramaiah Nagaraja, Kenneth R Boheler, Dennis Taub, Richard J Hodes, Dan L Longo, David Schlessinger, Jonathan Keller, Emily Klotz, Garnett Kelsoe, Akihiro Umezawa, Angelo L Vescovi, Janet Rossant, Tilo Kunath, Brigid L M Hogan, Anna Curci, Michele D'Urso, Janet Kelso, Winston Hide, Minoru S H Ko
Publikováno v:
PLoS Biology, Vol 1, Iss 3, p E74 (2003)
Understanding and harnessing cellular potency are fundamental in biology and are also critical to the future therapeutic use of stem cells. Transcriptome analysis of these pluripotent cells is a first step towards such goals. Starting with sources th
Externí odkaz:
https://doaj.org/article/1708d315f6714b659334ba91f551e95e
Autor:
Norie Tooi, Ayae Kinoshita, Hisae Nishioka, John E. Heuser, Makoto Honda, Nobuhiro Morone, Norio Nakatsuji, Itsunari Minami, Kazuhiro Aiba, Kengo Uemura
Publikováno v:
Biochemical and Biophysical Research Communications. 469:587-592
Cellular disease models are useful tools for Alzheimer's disease (AD) research. Pluripotent stem cells, including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), are promising materials for creating cellular models of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab9a75429dd7f3f0919dc5e5a1d9771
https://doi.org/10.1016/j.bbrc.2015.12.025
https://doi.org/10.1016/j.bbrc.2015.12.025
Publikováno v:
Nihon rinsho. Japanese journal of clinical medicine. 73
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5e57873698ab112897af7a9f25c83e0
https://pubmed.ncbi.nlm.nih.gov/30458092
https://pubmed.ncbi.nlm.nih.gov/30458092