Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Kazuhiro, Kudoh"'
Autor:
Yutaro Hara, Hiroki Mizukami, Keisuke Yamazaki, Takahiro Yamada, Akiko Igawa, Yuki Takeuchi, Takanori Sasaki, Hanae Kushibiki, Kotaro Murakami, Kazuhiro Kudoh, Keinosuke Ishido, Kenichi Hakamada
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 5, Pp 354-366 (2023)
Abstract Diabetes mellitus (DM) is a risk factor for pancreatic ductal adenocarcinoma (PDAC) that promotes the promoter methylation of CDH1. It is still unclear whether DM can exert other epigenetic effects, such as altering microRNA (miR) expression
Externí odkaz:
https://doaj.org/article/49220e3a8e094148a1c67db469d803bb
Autor:
Xuekai Pan, Hiroki Mizukami, Yutaro Hara, Takahiro Yamada, Keisuke Yamazaki, Kazuhiro Kudoh, Yuki Takeuchi, Takanori Sasaki, Hanae Kushibiki, Akiko Igawa, Kenichi Hakamada
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 1, Pp 132-144 (2023)
ABSTRACT Aims/Introduction The mismatch repair (MMR) protein recognizes DNA replication errors and plays an important role in tumorigenesis, including pancreatic ductal adenocarcinoma (PDAC). Although PMS2, a MMR protein, is degraded under oxidative
Externí odkaz:
https://doaj.org/article/6998ae817b84431d853edfa8cde7bac6
Autor:
Hiroki Mizukami, Kazuhiro Kudoh
Publikováno v:
Journal of Diabetes Investigation, Vol 13, Iss 1, Pp 6-13 (2022)
ABSTRACT The etiology of type 2 diabetes is multifactorial, in which environmental and genetic factors are involved to varying degrees. This suggests that its pathophysiology might vary depending on the individuals. Knowledge of the differences is cr
Externí odkaz:
https://doaj.org/article/224a8724e03c493b818c33c9d1e7d4b3
Autor:
Kazuhisa Takahashi, Hiroki Mizukami, Sho Osonoi, Yuki Takeuchi, Kazuhiro Kudoh, Takanori Sasaki, Makoto Daimon, Soroku Yagihashi
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 12, Pp 2149-2161 (2021)
Abstract Aims/Introduction Islets have microvessels that might develop pathological alterations similar to microangiopathy in type 2 diabetes patients. It remains unclear, however, whether the changes correlate with endocrine cell deficits or whether
Externí odkaz:
https://doaj.org/article/5334ab9d195d4893b04422432831e72f
Autor:
Sho Osonoi, Hiroki Mizukami, Yuki Takeuchi, Hikari Sugawa, Saori Ogasawara, Shizuka Takaku, Takanori Sasaki, Kazuhiro Kudoh, Koichi Ito, Kazunori Sango, Ryoji Nagai, Yasuhiko Yamamoto, Makoto Daimon, Hiroshi Yamamoto, Soroku Yagihashi
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
It is suggested that activation of receptor for advanced glycation end products (RAGE) induces proinflammatory response in diabetic nerve tissues. Macrophage infiltration is invoked in the pathogenesis of diabetic polyneuropathy (DPN), while the asso
Externí odkaz:
https://doaj.org/article/8b94de940bb9438eb3a6b8cf190a6aa7
Autor:
Yuki Takeuchi, Hiroki Mizukami, Kazuhiro Kudoh, Sho Osonoi, Takanori Sasaki, Hanae Kushibiki, Saori Ogasawara, Yutaro Hara, Akiko Igawa, Xuekai Pan, Takahiro Yamada, Keisuke Yamazaki, Tatsuya Mikami, Makoto Daimon, Soroku Yagihashi, Kenichi Hakamada, Shigeyuki Nakaji
Publikováno v:
Neurobiology of Disease, Vol 173, Iss , Pp 105839- (2022)
Small fibre neuropathy (SFN) is an initial pathology of diabetic polyneuropathy (DPN). Serum lipopolysaccharide binding protein levels are positively correlated with the pain threshold in the foot, suggesting that the abundance of gut Gram-negative b
Externí odkaz:
https://doaj.org/article/804f72b69a584cf08541270d878eeaff
Autor:
Kazuhisa Takahashi, Hiroki Mizukami, Sho Osonoi, Saori Ogasawara, Yutaro Hara, Kazuhiro Kudoh, Yuki Takeuchi, Takanori Sasaki, Makoto Daimon, Soroku Yagihashi
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105392- (2021)
Inflammation and oxidative stress contribute to the pathophysiology of diabetic neuropathy. According to recent evidence, the modulation of macrophage polarization in peripheral nerves represents a potential therapeutic target for diabetic neuropathy
Externí odkaz:
https://doaj.org/article/8c8c5f6043574b0087c1e304929ebcb3
Autor:
Kazuhiro Kudoh, Hiroki Mizukami, Chieko Itabashi, Nobuo Fuke, Sho Osonoi, Kanichiro Wada, Akiko Igawa, Saori Ogasawara, Yasuyuki Ishibashi, Kenichi Hakamada, Soroku Yagihashi, Shigeyuki Nakaji
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
Introduction Small fiber neuropathy (SFN) is an early manifestation in diabetic polyneuropathy (DPN); however, the mechanisms are not fully understood. In diabetes, SFN is presumed to be common in individuals with overt DPN, enhancing activation of p
Externí odkaz:
https://doaj.org/article/981385343e30429080b52457061bd6a6
Autor:
Chiaki Uchida, Hiroki Mizukami, Yutaro Hara, Takeshi Saito, Satoko Umetsu, Akiko Igawa, Sho Osonoi, Kazuhiro Kudoh, Yasuhiko Yamamoto, Hiroshi Yamamoto, Soroku Yagihashi, Kenichi Hakamada
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11716 (2021)
Pancreatic stellate cells (PSCs) mainly consist of cancer-associating fibroblasts in pancreatic ductal adenocarcinoma (PDAC). The receptor for advanced glycation end products (RAGE) is implicated in the pathophysiology of diabetic complications. Here
Externí odkaz:
https://doaj.org/article/17044c4b692544f5832864a0407f0f4f
Autor:
Sho Osonoi, Hiroki Mizukami, Chieko Itabashi, Kanichiro Wada, Kazuhiro Kudoh, Akiko Igawa, Saori Ogasawara, Yasuyuki Ishibashi, Makoto Daimon, Soroku Yagihashi, Shigeyuki Nakaji
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8306 (2020)
Normal-high HbA1c levels are a risk factor for attenuated pain sensation in normoglycemic subjects. It is unclear, however, what mechanisms underlie the pathogenesis of attenuated pain sensation in such a population. We, therefore, explored the relat
Externí odkaz:
https://doaj.org/article/6979619c7bff45d593bd139a3cd548de