Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kazuhiro, Chihara"'
Autor:
Yuka Yoshino, Yuta Fujii, Kazuhiro Chihara, Aya Nakae, Jun-ichiro Enmi, Yoshichika Yoshioka, Izuru Miyawaki
Publikováno v:
Toxicology Reports, Vol 12, Iss , Pp 1-9 (2024)
Drug-induced steatohepatitis is considered more serious than drug-induced hepatic steatosis, so that differentiating between the two is crucial in drug development. In addition, early detection of drug-induced steatohepatitis is considered important
Externí odkaz:
https://doaj.org/article/d3fe9ac1385942c88e0bb95af9ef75d6
Autor:
Yuka Yoshino, Yuta Fujii, Kazuhiro Chihara, Aya Nakae, Jun-ichiro Enmi, Yoshichika Yoshioka, Izuru Miyawaki
Publikováno v:
Toxicology Reports, Vol 10, Iss , Pp 481-486 (2023)
No method of monitoring drug-induced hepatic steatosis has been established, which is a concern in drug development. Hepatic steatosis is divided into diffuse and non-diffuse forms according to the pattern of fat deposition. Diffuse hepatic steatosis
Externí odkaz:
https://doaj.org/article/a62356ed7679451786ca40cbc0c7c706
Autor:
Yuta Fujii, Yuka Yoshino, Kazuhiro Chihara, Aya Nakae, Jun-ichiro Enmi, Yoshichika Yoshioka, Izuru Miyawaki
Publikováno v:
Toxicology Reports, Vol 10, Iss , Pp 97-103 (2023)
There are no specific and sensitive biomarkers for arteritis, and the occurrence of arteritis in nonclinical toxicological studies of a candidate drug makes development of the drug very difficult. However, we showed in a previous study that the high
Externí odkaz:
https://doaj.org/article/7b724274792644abb74bfb7db292f600
Autor:
Yuta Fujii, Yuka Yoshino, Kazuhiro Chihara, Aya Nakae, Jun-ichiro Enmi, Yoshichika Yoshioka, Izuru Miyawaki
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 1595-1602 (2022)
A method capable of identifying drug-induced arteritis is highly desirable because no specific and sensitive biomarkers have yet been defined. Although magnetic resonance imaging (MRI) may be used to find a biomarker candidate for drug-induced arteri
Externí odkaz:
https://doaj.org/article/09f847ecd7ad4334bd6e543eb6c78d90
Autor:
Makiko Kuwagata, Akira Sato, Yuko Izumi, Kazuhiro Chihara, Hanako Yamasaki, Yoshihiro Katsumata, Yojiro Ooshima, Jochen Buschmann, Michio Fujiwara
Publikováno v:
Congenital Anomalies. 62:198-202
Autor:
Tomoaki, Tochitani, Yasuhiro, Sasaki, Naoe, Nishimura, Yuta, Fujii, Takayuki, Iwaisako, Naohisa, Umeya, Masayo, Hashimoto, Hiroshi, Inada, Kazuhiro, Chihara, Izuru, Miyawaki
Publikováno v:
The Journal of Toxicological Sciences. 47:269-276
Microsampling (MS) has been increasingly used in toxicity studies reducing animal use for toxicokinetic analysis. However, especially for drugs with hematotoxic properties, the potential effects of MS on hematological parameters and subsequent toxici
Autor:
Makiko, Kuwagata, Akira, Sato, Yuko, Izumi, Kazuhiro, Chihara, Hanako, Yamasaki, Yoshihiro, Katsumata, Yojiro, Ooshima, Jochen, Buschmann, Michio, Fujiwara
Publikováno v:
Congenital anomaliesREFERENCES. 62(5)
In recent years, the Japanese Teratology Society has worked with the DevTox Berlin Workshops project to provide internationally consistent terminology for teratogenic effects. This paper summarizes a satellite workshop of the 60th Annual Meeting of t
Autor:
Akihiko Kiyoshi, Isao Shimizu, Yasunori Katsura, Tadashi Tsubouchi, Kiyoko Bando, Seiko Oku, Shinji Tsujimoto, Toru Yamada, Kazuhiro Chihara, Yukiko Mine, Takeshi Kunimatsu
Publikováno v:
European Journal of Pharmacology. 826:96-105
The pharmacological activity of DSP-6952, a novel compound was investigated, compared to that of clinically efficacious gastrointestinal (GI) prokinetic 5-hydroxytryptamine 4 (5-HT 4 ) receptor agonists. DSP-6952 had a strong affinity of K i = 51.9 n
Autor:
Kohei Shiota, Michio Fujiwara, Yoshihiro Katsumata, Yojiro Ooshima, Kazuhiro Chihara, Yuko Izumi
Publikováno v:
Congenital Anomalies. 58:82-86
Categorization of fetal external findings in common laboratory animals, intended to make the agreement at Berlin Workshop in 2014 more practical, was proposed by the Terminology Committee of the Japanese Teratology Society at the Workshop in the 55th
Autor:
Tadashi, Tsubouchi, Takeshi, Kunimatsu, Shinji, Tsujimoto, Akihiko, Kiyoshi, Yasunori, Katsura, Seiko, Oku, Kazuhiro, Chihara, Yukiko, Mine, Toru, Yamada, Isao, Shimizu, Kiyoko, Bando
Publikováno v:
European journal of pharmacology. 826
The pharmacological activity of DSP-6952, a novel compound was investigated, compared to that of clinically efficacious gastrointestinal (GI) prokinetic 5-hydroxytryptamine