Zobrazeno 1 - 10
of 654
pro vyhledávání: '"Kazuhiko Yanai"'
Autor:
Takahiro Morito, Ryuichi Harada, Ren Iwata, Yoichi Ishikawa, Nobuyuki Okamura, Yukitsuka Kudo, Shozo Furumoto, Kazuhiko Yanai, Manabu Tashiro
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0287047 (2023)
Astrogliosis is a crucial feature of neuroinflammation and is characterized by the significant upregulation of glial fibrillary acidic protein (GFAP) expression. Hence, visualizing GFAP in the living brain of patients with damaged central nervous sys
Externí odkaz:
https://doaj.org/article/3c88a4a5c263466ba1c2fdefa596ae5c
Autor:
Fumito Naganuma, Tadaho Nakamura, Hiroshi Kuroyanagi, Masato Tanaka, Takeo Yoshikawa, Kazuhiko Yanai, Nobuyuki Okamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Designer receptor activated by designer drugs (DREADDs) techniques are widely used to modulate the activities of specific neuronal populations during behavioural tasks. However, DREADDs-induced modulation of histaminergic neurons in the tube
Externí odkaz:
https://doaj.org/article/1f9e12f39843402183a0d3fe3debd20f
Autor:
Takahiro Morito, Ryuichi Harada, Ren Iwata, Yiqing Du, Nobuyuki Okamura, Yukitsuka Kudo, Kazuhiko Yanai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Brain positron emission tomography (PET) imaging with radiolabelled proteins is an emerging concept that potentially enables visualization of unique molecular targets in the brain. However, the pharmacokinetics and protein radiolabelling met
Externí odkaz:
https://doaj.org/article/1ed6b02705444b138a1da6dafa57c210
Autor:
Ryuichi Harada, Shozo Furumoto, Yukitsuka Kudo, Kazuhiko Yanai, Victor L. Villemagne, Nobuyuki Okamura
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Many neurodegenerative diseases are neuropathologically characterized by neuronal loss, gliosis, and the deposition of misfolded proteins such as β-amyloid (Aβ) plaques and tau tangles in Alzheimer’s disease (AD). In postmortem AD brains, reactiv
Externí odkaz:
https://doaj.org/article/617049dc61ba4599b256e81ca1baa9ea
Autor:
Michinori Ezura, Akio Kikuchi, Nobuyuki Okamura, Aiko Ishiki, Takafumi Hasegawa, Ryuichi Harada, Shoichi Watanuki, Yoshihito Funaki, Kotaro Hiraoka, Toru Baba, Naoto Sugeno, Shun Yoshida, Junpei Kobayashi, Michiko Kobayashi, Ohito Tano, Shun Ishiyama, Takaaki Nakamura, Ichiro Nakashima, Shunji Mugikura, Ren Iwata, Yasuyuki Taki, Katsutoshi Furukawa, Hiroyuki Arai, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Yukitsuka Kudo, Atsushi Takeda, Masashi Aoki
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Introduction: We aimed to determine whether in vivo tau deposits and monoamine oxidase B (MAO-B) detection using 18F-THK5351 positron emission tomography (PET) can assist in the differential distribution in patients with corticobasal syndrome (CBS),
Externí odkaz:
https://doaj.org/article/32c907a418364c868797fbcc1c7cd9a0
Autor:
Anikó Kárpáti, Takeo Yoshikawa, Tadaho Nakamura, Tomomitsu Iida, Takuro Matsuzawa, Haruna Kitano, Ryuichi Harada, Kazuhiko Yanai
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 2, Pp 122-128 (2018)
Astrocytes play key roles in regulating brain homeostasis and neuronal activity. This is, in part, accomplished by the ability of neurotransmitters in the synaptic cleft to bind astrocyte membrane receptors, activating signalling cascades that regula
Externí odkaz:
https://doaj.org/article/d2badc78d4944a48a4ee5c8b968f0b29
Autor:
Aiko Ishiki, Ryuichi Harada, Hideaki Kai, Naomi Sato, Tomoko Totsune, Naoki Tomita, Shoichi Watanuki, Kotaro Hiraoka, Yoichi Ishikawa, Yoshihito Funaki, Ren Iwata, Shozo Furumoto, Manabu Tashiro, Hironobu Sasano, Tetsuyuki Kitamoto, Yukitsuka Kudo, Kazuhiko Yanai, Katsutoshi Furukawa, Nobuyuki Okamura, Hiroyuki Arai
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-10 (2018)
Abstract Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of progressive supranuclear palsy (PSP) cases. To confirm the binding target of radiotracer in PSP, we performed an
Externí odkaz:
https://doaj.org/article/27689a71ca88485fb74afdca3053d8aa
Autor:
Takamasa Yokoi, Hirohisa Watanabe, Hiroshi Yamaguchi, Epifanio Bagarinao, Michihito Masuda, Kazunori Imai, Aya Ogura, Reiko Ohdake, Kazuya Kawabata, Kazuhiro Hara, Yuichi Riku, Shinsuke Ishigaki, Masahisa Katsuno, Shinichi Miyao, Katsuhiko Kato, Shinji Naganawa, Ryuichi Harada, Nobuyuki Okamura, Kazuhiko Yanai, Mari Yoshida, Gen Sobue
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Background: Imaging studies in Alzheimer’s disease (AD) have yet to answer the underlying questions concerning the relationship among tau retention, neuroinflammation, network disruption and cognitive decline. We compared the spatial retention patt
Externí odkaz:
https://doaj.org/article/18bbf7f4c87f4874afbcd69527b13a5e
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Externí odkaz:
https://doaj.org/article/a8c1a68e01af4cbf938968a4b84d1411
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Neurodegenerative diseases characterized by pathological protein accumulation in cells are termed “proteinopathies.” Although various protein aggregates share cross-β-sheet structures, actual conformations vary among each type of protein deposit
Externí odkaz:
https://doaj.org/article/42ff5505d37c4ee9b248d89c3d7ee443