Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Kazuhiko Umesono"'
Autor:
Tokuko Haraguchi, Yasushi Hiraoka, Ken Ichirou Morohashi, Yoshihiro Nakatani, Hidesato Ogawa, Ruth T. Yu, Kazuhiko Umesono
Publikováno v:
Biochemical and Biophysical Research Communications. 320:218-225
Assembly of multi-protein complexes on promoter and enhancer elements is a prerequisite for onset of gene transcription. At the beginning of this process, transcription factors are thought to act as nucleating centers for complex formation through th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6650ae396c6eb9648e40a07e66a0fa1
https://doi.org/10.1016/j.bbrc.2004.05.161
https://doi.org/10.1016/j.bbrc.2004.05.161
Autor:
Xiao Fan Jiang, Hiroyasu Inoue, Shobu Namura, Takahiro Katayama, Shiho Osada, Kazuhiko Umesono
Publikováno v:
Neuroscience Letters. 352:203-206
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors which belong to the nuclear receptor family. We examined whether PPARalpha agonists and resveratrol, a polyphenol contained in grapes, protect the brain ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd72e1b77f6280d1752378121f2f333
https://doi.org/10.1016/j.neulet.2003.09.001
https://doi.org/10.1016/j.neulet.2003.09.001
Publikováno v:
Proceedings of the National Academy of Sciences. 98:12403-12408
Orphan receptors for whom cognate ligands have not yet been identified form a large subclass within the nuclear receptor superfamily. To address one aspect of how they might regulate transcription, we analyzed the mode of interaction between the Dros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971954b2c9901a4101a571aae72045b7
https://doi.org/10.1073/pnas.221552998
https://doi.org/10.1073/pnas.221552998
Publikováno v:
Genes & Development. 15:2111-2121
The retinoic acid receptors (RARs) recruit coactivator and corepressor proteins to activate or repress the transcription of target genes depending on the presence of retinoic acid (RA). Despite a detailed molecular understanding of how corepressor co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2168e7d9b7c2b87e4ffb9fd2d851c5
https://doi.org/10.1101/gad.908801
https://doi.org/10.1101/gad.908801
Publikováno v:
Molecular and Cellular Biology. 20:8731-8739
The vitamin A derivative retinoic acid (RA) has been suggested to play important roles in vertebrate embryonic development and cell differentiation. Vitamin A deficiency and/or excessive doses of RA are known to result in a spectrum of distinct malfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d911daecc76b17ac56e838ea4abb3351
https://doi.org/10.1128/mcb.20.23.8731-8739.2000
https://doi.org/10.1128/mcb.20.23.8731-8739.2000
Publikováno v:
Journal of Biological Chemistry. 275:28028-28032
Cyclooxygenase-2 (COX-2), a rate-limiting enzyme for prostaglandins (PG), plays a key role in inflammation, tumorigenesis, development, and circulatory homeostasis. The PGD(2) metabolite 15-deoxy-Delta(12, 14) PGJ(2) (15d-PGJ(2)) was identified as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661e7a2a5519a0bd585083101603c08d
https://doi.org/10.1074/jbc.m001387200
https://doi.org/10.1074/jbc.m001387200
Autor:
H. Eric Xu, Steven A. Kliewer, Ronald M. Evans, Millard H. Lambert, Valerie G. Montana, Ruth T. Yu, Ichiro Takada, Kazuhiko Umesono
Publikováno v:
Molecular Endocrinology. 14:733-740
Three pharmacologically important nuclear receptors, the peroxisome proliferator-activated receptors (PPARs α,γ , and δ), mediate key transcriptional responses involved in lipid homeostasis. The PPARα and γ subtypes are well conserved from Xenop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b00327db4898cd94725a53ba5862bd54
https://doi.org/10.1210/me.14.5.733
https://doi.org/10.1210/me.14.5.733
Autor:
Kazuhiko Umesono, Steven A. Kliewer, Valerie G. Montana, Ronald M. Evans, I. Takada, H.E. Xu, Ruth T. Yu, Millard H. Lambert
Publikováno v:
Molecular Endocrinology. 14:733-740
Three pharmacologically important nuclear receptors, the peroxisome proliferator-activated receptors (PPARs α,γ , and δ), mediate key transcriptional responses involved in lipid homeostasis. The PPARα and γ subtypes are well conserved from Xenop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e07e67515e6f953bab9d8264d4abb09
https://doi.org/10.1210/mend.14.5.0456
https://doi.org/10.1210/mend.14.5.0456
Autor:
Wanda Sicinska, Hiroshi Ooizumi, Kazuhiko Umesono, Hiroyuki Masuno, Keiko Yamamoto, Tetsuya Taga, Kinichi Nakashima, Hector F. DeLuca, Mihwa Choi, Sachiko Yamada, Janeen L. Vanhooke
Publikováno v:
Proceedings of the National Academy of Sciences. 97:1467-1472
The ligand binding domain of the human vitamin D receptor (VDR) was modeled based on the crystal structure of the retinoic acid receptor. The ligand binding pocket of our VDR model is spacious at the helix 11 site and confined at the β-turn site. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9700d943c52a55714cf77b2e8966a5e0
https://doi.org/10.1073/pnas.020522697
https://doi.org/10.1073/pnas.020522697
Autor:
Kunio Yasuda, Jun K. Takeuchi, Tsuyoshi Momose, Kazuhiko Umesono, Akane Tonegawa, Hidesato Ogawa
Publikováno v:
Development, Growth and Differentiation. 41:335-344
During vertebrate embryonic development, a key to unraveling specific functions of gene products is the capability to manipulate expression of the gene of interest at the desired time and place. For this, we developed a 'microelectroporation' techniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7bd87adcd4d92eee5c174d7569b1997
https://doi.org/10.1046/j.1440-169x.1999.413437.x
https://doi.org/10.1046/j.1440-169x.1999.413437.x