Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Kazuhiko Tanzawa"'
Autor:
Takahiko Naruko, Kazuo Haze, Minoru Yoshiyama, Yoshimi Sugama, Takeshi Inoue, Masahiko Ohsawa, Akira Itoh, Shoichi Ehara, Chizuko Kitabayashi, Yoshihiro Ikura, Junichi Yoshikawa, Kazuhiko Tanzawa, Makiko Ueda, Nobuyuki Shirai, Michihiko Hirayama
Publikováno v:
Journal of Hypertension. 24:711-721
The repair process at the site of injury after percutaneous coronary intervention (PCI) is dominated by neointimal formation composed mainly of smooth muscle cells (SMC). Endothelin-1 (ET-1) is a powerful vasoconstrictor and SMC mitogen. Endothelin-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8aff6baf167ff10d51caa560d7c48e5
https://doi.org/10.1097/01.hjh.0000217854.97369.8c
https://doi.org/10.1097/01.hjh.0000217854.97369.8c
Autor:
Mika Ikebe, Yushi Nakayama, Kimio Tomita, Yuka Tashima, Hiroshi Nonoguchi, Kohei Shimada, Kazuhiko Tanzawa
Publikováno v:
Nephron Experimental Nephrology. 94:e137-e145
Background: Nephrotic syndrome is characterized by severe proteinuria and sodium and water retention. Although endothelin (ET) 1 can cause natriuresis or antinatriuresis, the role played by ET-1 in proteinuria and in sodium retention due to nephrotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339c86426a88f17a61142a080ca1183f
https://doi.org/10.1159/000072497
https://doi.org/10.1159/000072497
Ontogeny of Endothelin-Converting Enzyme Gene Expression and Protein Content in the Ovine Fetal Lung
Publikováno v:
Neonatology. 81:139-144
Endothelin 1 (ET-1) is a potent vasoconstrictor and smooth muscle comitogen that is produced by endothelin-converting enzyme 1 (ECE-1) in endothelium and smooth muscle of the vascular wall in adult pulmonary arteries. However, little is known about t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0655a77046b7ef1a52a594f0ec3768d
https://doi.org/10.1159/000047199
https://doi.org/10.1159/000047199
Autor:
Tomoyuki Shibata, Kazuhiko Tamaki, Shuichi Miyamoto, Kazuhiko Tanzawa, Aki Matsubara, Yoriko Iwata, Reiko Ohiwa
Publikováno v:
Chem-Bio Informatics Journal. 1:23-34
Three-dimensional models of the gelatinase catalytic domains were built from collagenase structures by the homology modeling technique. The docking of different types of inhibitors was then studied in an attempt to obtain structural insight into thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3956e8c454e55cb44b7e9fda03b68394
https://doi.org/10.1273/cbij.1.23
https://doi.org/10.1273/cbij.1.23
Autor:
Thiennu H. Vu, Shigeyoshi Itohara, Douglas Hanahan, Takeshi Itoh, Rolf A. Brekken, Philip E. Thorpe, Zena Werb, Gerald McMahon, Kazuhiko Tanzawa, Gabriele Bergers, Kazuhiko Tamaki
Publikováno v:
Nature Cell Biology. 2:737-744
During carcinogenesis of pancreatic islets in transgenic mice, an angiogenic switch activates the quiescent vasculature. Paradoxically, vascular endothelial growth factor (VEGF) and its receptors are expressed constitutively. Nevertheless, a syntheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37874a3182ca7c50570eabc58a886bd8
https://doi.org/10.1038/35036374
https://doi.org/10.1038/35036374
Publikováno v:
Journal of Biochemistry. 126:449-455
Erosion of cartilage is a major feature of joint diseases, i.e., osteoarthritis and rheumatoid arthritis, which leads with time to a loss of joint function. Proteolytic cleavage of the aggrecan core protein is a key event in the progress of these joi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b67181594f29964393f7a7bf19502ad
https://doi.org/10.1093/oxfordjournals.jbchem.a022471
https://doi.org/10.1093/oxfordjournals.jbchem.a022471
Autor:
Masaaki Takahashi, Yoriko Iwata, Yumi Kawase, Hitoshi Hotoda, Masakatsu Kaneko, Shuichi Miyamoto, Kazuhiko Tanzawa, Kazuhiro Murayama
Publikováno v:
Biochemistry. 38:9234-9241
The recognition mode of adenophostin A at the D-myo-inositol 1,4, 5-trisphosphate [Ins(1,4,5)P(3)] receptor was investigated. Comparison of conformations of Ins(1,4,5)P(3) and adenophostin A by using the combination of NMR and molecular mechanics (MM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13148d6f299338375e0e8e2c6b23fad3
https://doi.org/10.1021/bi990114r
https://doi.org/10.1021/bi990114r
Autor:
Masahiko Watanabe, Tomowo Kobayashi, Tetsuro Kubota, Kazuhiko Tamaki, Naoki Igarashi, Koichiro Kumai, Kazuhiko Tanzawa, Masaki Kitajima, Tatsuo Teramoto, Yoshihide Otani, Shinjiro Wilson Matsuzaki
Publikováno v:
Japanese Journal of Cancer Research : Gann
R-94138, a matrix metalloproteinase inhibitor, was examined for the ability to prevent peritoneal dissemination of a human gastric cancer xenograft, TMK-1. When the supernatant of a co-culture of TMK-1 cells and human normal fibroblast cells was subj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2718d71a5617ab79afc4f643e2fd9b
https://doi.org/10.1111/j.1349-7006.1999.tb00674.x
https://doi.org/10.1111/j.1349-7006.1999.tb00674.x
Publikováno v:
Journal of Biological Chemistry. 273:31815-31821
In most non-excitable cells, calcium influx is signaled by depletion of intracellular calcium stores, a process known as capacitative calcium entry. Adenophostin A, a potent activator of the inositol 1, 4,5-trisphosphate receptor, has been reported t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f870f84799f0fad37bcf4caec89443
https://doi.org/10.1074/jbc.273.48.31815
https://doi.org/10.1074/jbc.273.48.31815
Publikováno v:
Journal of Biological Chemistry. 273:24360-24367
The cell-surface activation of pro-matrix metalloproteinase 2 (pro-MMP-2) is considered to be critical for cell migration and invasion. Treatment of human uterine cervical fibroblasts with concanavalin A activates pro-MMP-2 on the cell surface by con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52dfc2e629f0c422311ed82e34b0ec9b
https://doi.org/10.1074/jbc.273.38.24360
https://doi.org/10.1074/jbc.273.38.24360