Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability

Autor: Roman Fukui, Ryo Saga, Yusuke Matsuya, Kazuo Tomita, Yoshikazu Kuwahara, Kentaro Ohuchi, Tomoaki Sato, Kazuhiko Okumura, Hiroyuki Date, Manabu Fukumoto, Yoichiro Hosokawa

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Cancer stem-like cells (CSCs) within solid tumors exhibit radioresistance, leading to recurrence and distant metastasis after radiotherapy. To experimentally study the characteristics of CSCs, radioresistant cell lines were successfully esta

Externí odkaz: https://doaj.org/article/b9f986bf3be149b6982973fd1e3addd7

Two-dimensional ton transportation numerical simulation of anode cell of electrolyzed water generator

Autor: Manabu KODAMA, Yoshihisa TOSE, Kazuhiko OKUMURA, Shuichiro HIRAI

Publikováno v: Nihon Kikai Gakkai ronbunshu, Vol 86, Iss 892, Pp 20-00183-20-00183 (2020)

Electrolyzed water generator can produce acidic and alkaline water from tap water and electric power, and is expected to have applications in the food and medical fields for sterilization, cleaning and disinfection. However, there are still many unkn

Externí odkaz: https://doaj.org/article/a0ff1e14bbec42dba596b6434ede4e03

DNA‑PKcs phosphorylation specific inhibitor, NU7441, enhances the radiosensitivity of clinically relevant radioresistant oral squamous cell carcinoma cells

Autor: Kentaro Ohuchi, Ryo Saga, Kazuki Hasegawa, Eichi Tsuruga, Yoichiro Hosokawa, Manabu Fukumoto, Kazuhiko Okumura

Publikováno v: Biomed Rep

Radioresistant cancer cells lead to poor prognosis after radiotherapy. However, the mechanisms underlying cancer cell radioresistance have not been fully elucidated. Thus, the DNA damage response of clinically relevant radioresistant oral squamous ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a31169dae750813c7e5efd9258794d
https://europepmc.org/articles/PMC10011949/

4‑methylumbelliferone inhibits clonogenic potency by suppressing high molecular weight‑hyaluronan in fibrosarcoma cells

Autor: Yoichiro Hosokawa, Rei Takahashi, Ryo Saga, Kazuhiko Okumura, Kazuki Hasegawa, Roman Fukui, Mitsuru Chiba, Eichi Tsuruga

Publikováno v: Oncology Letters

The inflammatory response is closely associated with cancer cell survival. It has been reported that inflammatory signaling cascades promote tumor survival and exert detrimental effects in normal tissue. Hyaluronans have different cellular functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2b2b0ef2a55af448da1b94418ea932
https://doi.org/10.3892/ol.2020.11370

miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway

Autor: Kazuki Saito, Marija Krstic-Demonacos, Miwa Hayashi, Kazuhiko Okumura, Hiroshi Isogai, Kengo Kuroda, Emiko Isogai, Tomokazu Fukuda, Constantinos Demonacos

Publikováno v: BMC Cancer
Kuroda, K, Fukuda, T, Krstic-Demonacos, M, Demonacos, C, Okumura, K, Isogai, H, Hayashi, M, Saito, K & Isogai, E 2017, ' miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway ', BMC Cancer . https://doi.org/10.1186/s12885-016-3003-9

Background Antimicrobial peptides (AMPs) play important roles in the innate immune system of all life forms and recently have been characterized as multifunctional peptides that have a variety of biological roles such as anticancer agents. However, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f992d2f3d4e8181d2eebbc38885bb2
http://europepmc.org/articles/PMC5219750