Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Kazuhiko Nakatani"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Circular RNAs (circRNAs), are a covalently closed, single-stranded RNA without 5′- and 3′-termini, commonly stem from the exons of precursor mRNAs (pre-mRNAs). They have recently garnered interest, with studies uncovering their pivotal r
Externí odkaz:
https://doaj.org/article/0680d4acfc5d45209a721c2357bdb71a
Autor:
Yuzo Fujino, Morio Ueyama, Taro Ishiguro, Daisaku Ozawa, Hayato Ito, Toshihiko Sugiki, Asako Murata, Akira Ishiguro, Tania Gendron, Kohji Mori, Eiichi Tokuda, Tomoya Taminato, Takuya Konno, Akihide Koyama, Yuya Kawabe, Toshihide Takeuchi, Yoshiaki Furukawa, Toshimichi Fujiwara, Manabu Ikeda, Toshiki Mizuno, Hideki Mochizuki, Hidehiro Mizusawa, Keiji Wada, Kinya Ishikawa, Osamu Onodera, Kazuhiko Nakatani, Leonard Petrucelli, Hideki Taguchi, Yoshitaka Nagai
Publikováno v:
eLife, Vol 12 (2023)
Abnormal expansions of GGGGCC repeat sequence in the noncoding region of the C9orf72 gene is the most common cause of familial amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). The expanded repeat sequence is translated into dip
Externí odkaz:
https://doaj.org/article/8c6f0fd5d0eb4801aca51cdb76aeb73a
Autor:
Sanjukta Mukherjee, Asako Murata, Ryoga Ishida, Ayako Sugai, Chikara Dohno, Michiaki Hamada, Sudhir Krishna, Kazuhiko Nakatani
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 165-174 (2022)
Selective targeting of biologically relevant RNAs with small molecules is a long-standing challenge due to the lack of clear understanding of the binding RNA motifs for small molecules. The standard SELEX procedure allows the identification of specif
Externí odkaz:
https://doaj.org/article/4395786fe8e84c3e961dcc08eaac9c5a
Autor:
Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Synthetic small molecules modulating RNA structure and function have therapeutic potential for RNA diseases. Here the authors show the mechanism by which a small molecule targets the disease-causing r(UGGAA) n repeat RNAs in spinocerebellar ataxia ty
Externí odkaz:
https://doaj.org/article/fb74152ab4824a57b44c57a7b829b312
Autor:
Yuhei Hasuike, Hana Tanaka, Terence Gall-Duncan, Mustafa Mehkary, Kazuhiko Nakatani, Christopher E. Pearson, Shoji Tsuji, Hideki Mochizuki, Masayuki Nakamori
Publikováno v:
Neurobiology of Disease, Vol 163, Iss , Pp 105604- (2022)
Dentatorubral–pallidoluysian atrophy (DRPLA) is a devastating genetic disease presenting myoclonus, epilepsy, ataxia, and dementia. DRPLA is caused by the expansion of a CAG repeat in the ATN1 gene. Aggregation of the polyglutamine-expanded ATN1 pr
Externí odkaz:
https://doaj.org/article/8160c9e3f4024526b8f022fa65b12ddd
Autor:
Huixin Chen, Mariya Parimelalagan, Fumie Takei, Hapuarachchige Chanditha Hapuarachchi, Evelyn Siew-Chuan Koay, Lee Ching Ng, Phui San Ho, Kazuhiko Nakatani, Justin Jang Hann Chu
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004887 (2016)
A molecular diagnostic platform with DANP-anchored hairpin primer was developed and evaluated for the rapid and cost-effective detection of Chikungunya virus (CHIKV) with high sensitivity and specificity. The molecule 2, 7-diamino-1, 8-naphthyridine
Externí odkaz:
https://doaj.org/article/eb7a2ae4b8f04d0eac37ec3354e56edb
Publikováno v:
Biochemistry. 61:2522-2530
The stable R-loop formed during transcription induces enzyme-mediated deamination of cytosine, and the uracil in the DNA produced activates the base excision repair (BER) pathway. DNA cleavage involved in the BER pathway is thought to be one of the p
Autor:
Kazuhiko, Nakatani
Publikováno v:
Proceedings of the Japan Academy, Series B. 98:30-48
The instability of repeat sequences in the human genome results in the onset of many neurological diseases if the repeats expand above a certain threshold. The transcripts containing long repeats sequester RNA binding proteins. The mechanism of repea
Publikováno v:
Chemical Communications. 58:3629-3632
Circular RNAs (circRNA) are covalently-closed single stranded RNAs with potent roles in cells. Here, we demonstrate the feasibility of mediating circRNA production in a model environment via a small molecule: naphthyridine carbamate dimer (NCD).
Publikováno v:
The Journal of Organic Chemistry. 87:340-350
Small molecules targeting DNA regions with structural fluctuation are an important class of molecule as chemical probes for studying the role of these structures in biological systems and the development of neurological disorders. The molecule