Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Kazuhiko Kume"'
Autor:
Daisuke Mori, Chihiro Inami, Ryosuke Ikeda, Masahito Sawahata, Shinji Urata, Sho T. Yamaguchi, Yohei Kobayashi, Kosuke Fujita, Yuko Arioka, Hiroki Okumura, Itaru Kushima, Akiko Kodama, Toshiaki Suzuki, Takashi Hirao, Akira Yoshimi, Akira Sobue, Takahiro Ito, Yukikiro Noda, Hiroyuki Mizoguchi, Taku Nagai, Kozo Kaibuchi, Shigeo Okabe, Koji Nishiguchi, Kazuhiko Kume, Kiyofumi Yamada, Norio Ozaki
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Genetic factors significantly affect the pathogenesis of psychiatric disorders. However, the specific pathogenic mechanisms underlying these effects are not fully understood. Recent extensive genomic studies have implicated the protocadherin
Externí odkaz:
https://doaj.org/article/ded0670b05d74891b8e0763b61598f70
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Feeding behaviors are determined by two main factors. One is the internal state, such as hunger or previous experiences; the other is external factors, such as sensory stimulation. During starvation, animals must balance food-seeking behavio
Externí odkaz:
https://doaj.org/article/be71ac80fa874499925b16a54d68f743
Autor:
Daisuke Mori, Ryosuke Ikeda, Masahito Sawahata, Sho Yamaguchi, Akiko Kodama, Takashi Hirao, Yuko Arioka, Hiroki Okumura, Chihiro Inami, Toshiaki Suzuki, Yu Hayashi, Hidekazu Kato, Yoshihiro Nawa, Seiko Miyata, Hiroki Kimura, Itaru Kushima, Branko Aleksic, Hiroyuki Mizoguchi, Taku Nagai, Takanobu Nakazawa, Ryota Hashimoto, Kozo Kaibuchi, Kazuhiko Kume, Kiyofumi Yamada, Norio Ozaki
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Whole genome analysis has identified rare copy number variations (CNV) that are strongly involved in the pathogenesis of psychiatric disorders, and 3q29 deletion has been found to have the largest effect size. The 3q29 deletion mice model (3
Externí odkaz:
https://doaj.org/article/726eaa89594347c1a0578733db974080
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Sleep behavior has been observed from non-vertebrates to humans. Sleepy mutation in mice resulted in a notable increase in sleep and was identified as an exon-skipping mutation of the salt-inducible kinase 3 (Sik3) gene, conserved among animals. The
Externí odkaz:
https://doaj.org/article/08d35c71955a46749f1dfe995f1b1cfa
Autor:
Taku Miyagawa, Susumu Tanaka, Mihoko Shimada, Noriaki Sakai, Kotomi Tanida, Nozomu Kotorii, Tatayu Kotorii, Yu Ariyoshi, Yuji Hashizume, Kimihiro Ogi, Hiroshi Hiejima, Takashi Kanbayashi, Aya Imanishi, Azusa Ikegami, Yuichi Kamei, Akiko Hida, Yamato Wada, Masayuki Miyamoto, Masanori Takami, Hideaki Kondo, Yoshiyuki Tamura, Yukari Taniyama, Naoto Omata, Tomoyuki Mizuno, Shunpei Moriya, Hirokazu Furuya, Mitsuhiro Kato, Kayoko Kato, Jun Ishigooka, Kazuhito Tsuruta, Shigeru Chiba, Naoto Yamada, Masako Okawa, Koichi Hirata, Kenji Kuroda, Kazuhiko Kume, Naohisa Uchimura, Masaaki Kitada, Tohru Kodama, Yuichi Inoue, Seiji Nishino, Kazuo Mishima, Katsushi Tokunaga, Makoto Honda
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Idiopathic hypersomnia (IH) is a rare, heterogeneous sleep disorder characterized by excessive daytime sleepiness. In contrast to narcolepsy type 1, which is a well-defined type of central disorders of hypersomnolence, the etiology of IH is
Externí odkaz:
https://doaj.org/article/d07ab5f0adcd4703970a8ce887df5b95
Autor:
Tianxiang Gao, Jiayi Li, Yuji Watanabe, Chijung Hung, Akihiro Yamanaka, Kazumasa Horie, Masashi Yanagisawa, Masahiro Ohsawa, Kazuhiko Kume
Publikováno v:
Clocks & Sleep, Vol 3, Iss 4, Pp 581-597 (2021)
Sleep-stage classification is essential for sleep research. Various automatic judgment programs, including deep learning algorithms using artificial intelligence (AI), have been developed, but have limitations with regard to data format compatibility
Externí odkaz:
https://doaj.org/article/9a95b9ec07e24975b888f571a68b9e88
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0277918 (2022)
Sleep is required to maintain physiological functions and is widely conserved across species. To understand the sleep-regulatory mechanisms, sleep-regulating genes and neuronal circuits are studied in various animal species. In the sleep-regulatory n
Externí odkaz:
https://doaj.org/article/6b6849aeeac74b98a0894b164779b123
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The central complex is one of the major brain regions that control sleep in Drosophila. However, the circuitry details of sleep regulation have not been elucidated yet. Here, we show a novel sleep-regulating neuronal circuit in the protocerebral brid
Externí odkaz:
https://doaj.org/article/ad074a7053db47688ddf2a5e4c798f5c
Autor:
Riho Kobayashi, Junya Maruoka, Hiroaki Norimoto, Yuji Ikegaya, Kazuhiko Kume, Masahiro Ohsawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 141, Iss 1, Pp 79-82 (2019)
Hippocampal neurons play a crucial role in memory formation. Accumulating evidence raises the possibility that hippocampal sharp-wave ripples (SW-Rs) are involved in memory consolidation. Here, we examined in an animal model of diabetes and found the
Externí odkaz:
https://doaj.org/article/ec70b630a91248d1b2e6803311972a04
Publikováno v:
Journal of Pharmacological Sciences, Vol 134, Iss 3, Pp 158-165 (2017)
Plastic changes that increase nociceptive transmission are observed in several brain regions under conditions of chronic pain. Synaptic plasticity in the anterior cingulate cortex (ACC) is particularly associated with neuropathic pain. Glial cells ar
Externí odkaz:
https://doaj.org/article/d8c09cfff61f4b8ba3f46500dbfa40bd