Výsledky vyhledávání - "Kazuhiko Date"

ESTABLISHMENT AND CHARACTERIZATION OF A HUMAN B CELL LINE FROM THE LUNG TISSUE OF A PATIENT WITH SCLERODERMA; EXTRAORDINARY HIGH LEVEL OF IL-6 SECRETION BY STIMULATED FIBROBLASTS

Autor: Hidekazu Takagi, Masahiko Yoneda, Yoshihisa Nagata, Isamu Sugie, Kazuhiko Date, Takuya Matsui, Kazuo Kondo, Tadashi Okada, Kato S, Masashi Yoshihara

Publikováno v: Cytokine. 13:220-226

Progressive systemic sclerosis is a connective tissue disease of unknown aetiology. This is the first study to demonstrate induction by a human B cell line of IL-6 secretion from fibroblasts. The cell line was established from lesional lung tissue of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e6e49b01a6cebd090f31a13a35518c
https://doi.org/10.1006/cyto.2000.0822

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A model of port-site metastases of gallbladder cancer: The influence of peritoneal injury and its repair on abdominal wall metastases

Autor: Kazuhiko Date, Masao Tanaka, Hong Li, Hideo Shimura, Kazuhiro Mizumoto, Yasuaki Aoki

Publikováno v: Surgery. 125:553-559

Background: Recent surgical literature contains several reports of wound metastases of unexpected gallbladder cancer after laparoscopic cholecystectomy. We hypothesized that peritoneal injury caused by trocar insertion potentiates wound metastases. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbd406e7fea98a7dcb888f0d5b06d14
https://doi.org/10.1016/s0039-6060(99)70208-4

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Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor

Autor: Keiji Kuba, Kazuhiko Date, Hideo Shimura, Masao Tanaka, Toshikazu Nakamura, Kunio Matsumoto

Publikováno v: Oncogene. 17:3045-3054

Invasion of various carcinoma cells follows their interaction with stromal cells. Hepatocyte growth factor (HGF), four-kringle-containing growth factor, is a mesenchymal or stromal-derived mediator which affects the growth and the invasiveness of car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcf5217ab7e9ca16841ebce947d42ed
https://doi.org/10.1038/sj.onc.1202231

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Cooperative Interaction between α- and β-Chains of Hepatocyte Growth Factor on c-Met Receptor Confers Ligand-induced Receptor Tyrosine Phosphorylation and Multiple Biological Responses

Autor: Toshikazu Nakamura, Hirofumi Kataoka, Kazuhiko Date, Kunio Matsumoto

Publikováno v: Journal of Biological Chemistry. 273:22913-22920

Hepatocyte growth factor (HGF) is a heterodimeric molecule composed of the alpha-chain containing the N-terminal hairpin domain, four kringle domains, and the serine protease-like beta-chain. We prepared HGF/NK4 and HGF/beta from the entire HGF after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d8d631f57e23bbbe42e6fc9adf3180
https://doi.org/10.1074/jbc.273.36.22913

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[Untitled]

Autor: Hong Li, Toshikazu Nakamura, Kazuhiko Date, Kunio Matsumoto, Yasuaki Aoki, Hideo Shimura, Masao Tanaka

Publikováno v: Clinical and Experimental Metastasis. 16:74-82

Human gallbladder cancer is highly malignant and its prognosis is usually poor depending on the extent of surrounding tissue invasion. We examined in vitro the invasive activity of four gallbladder cancer cell lines (GB-d1, GB-h3, GB-d2 and FU-GBC-1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e42a870a9af6cf9b32fe40c080a0fd4
https://doi.org/10.1023/a:1006516119518

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Acquisition of invasive phenotype in gallbladder cancer cells via mutual interaction of stromal fibroblasts and cancer cells as mediated by hepatocyte growth factor

Autor: Toshikazu Nakamura, Kunio Matsumoto, Kazuhiko Date, Hideo Shimura

Publikováno v: Japanese Journal of Cancer Research : Gann

Growth and motility of carcinoma cells are regulated through their interactions with host stromal cells, i.e., tumor-stromal interactions. Hepatocyte growth factor (HGF), a ligand for c-Met tyrosine kinase, is a stromal-derived regulator of growth, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ac6721c10a7973be96d993f5c27492
https://pubmed.ncbi.nlm.nih.gov/8698619

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Hepatocyte growth factor in lung morphogenesis and tumor invasion: role as a mediator in epithelium-mesenchyme and tumor-stroma interactions

Autor: Kazuhiko Date, Kunio Matsumoto, Hidenori Ohmichi, Toshiichi Nakamura

Publikováno v: Cancer chemotherapy and pharmacology.

Hepatocyte growth factor (HGF), a ligand for Met tyrosine kinase, is a mesenchyme- or stroma-derived multipotent factor that regulates the growth, motility, and morphogenesis of various types of cells. During lung development, Met/HGF receptor mRNA w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe35387e10febfbd31b7d73f51d266ca
https://pubmed.ncbi.nlm.nih.gov/8765416

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HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor

Autor: Masao Tanaka, Hideo Shimura, Toshikazu Nakamura, Kunio Matsumoto, Kazuhiko Date

Publikováno v: FEBS Letters. (1):1-6

We prepared a specific antagonist for hepatocyte growth factor (HGF) and designated it HGF/NK4. HGF/NK4 is composed of N-terminal 447 amino acids of the α-chain of HGF, thus contains the N-terminal hairpin domain and subsequent four kringle domains.

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