Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kazuhiko, Shirakabe"'
Autor:
Takeshi Takajo, Kengo Tomita, Hanae Tsuchihashi, Shingo Enomoto, Masaaki Tanichi, Hiroyuki Toda, Yoshikiyo Okada, Hirotaka Furuhashi, Nao Sugihara, Akinori Wada, Kazuki Horiuchi, Kenichi Inaba, Yoshinori Hanawa, Naoki Shibuya, Kazuhiko Shirakabe, Masaaki Higashiyama, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Katsunori Kimura, Soichiro Miura, Kunio Shimizu, Ryota Hokari
Publikováno v:
Gut and Liver, Vol 13, Iss 3, Pp 325-332 (2019)
Background/Aims Although studies using conventional animal models have shown that specific stressors cause irritable bowel syndrome (IBS), it is unclear whether depression itself causes IBS. Our aim was to establish a rat model to determine if depres
Externí odkaz:
https://doaj.org/article/e9a7b567ada14be6bb016568f4f9f02a
Autor:
Naoki Shibuya, Rina Tanemoto, Chikako Watanabe, Shunsuke Komoto, Kenichi Yoshikawa, Ryota Hokari, Suguru Ito, Nao Sugihara, Yoshikiyo Okada, Kengo Tomita, Masaaki Higashiyama, Yoshinori Hanawa, Masayuki Saruta, Akinori Mizoguchi, Chie Kurihara, Akinori Wada, Yoshihiro Akita, Kazuki Horiuchi, Kenichi Inaba, Kazuhiko Shirakabe, Shin Nishii
Publikováno v:
Journal of Gastroenterology and Hepatology. 36:2523-2530
Background The small intestine plays a central role in gut immunity, and enhanced lymphocyte migration is involved in the pathophysiology of various enteropathy. Bile acid (BA) is closely related to lipid metabolism and gut microbiota, and essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71b14004d405f6508e6ac7422da2fbb
https://doi.org/10.1111/jgh.15509
https://doi.org/10.1111/jgh.15509
Autor:
Soichiro Miura, Shin Nishii, Kenichi Inaba, Shigeaki Nagao, Kengo Tomita, Hirotaka Furuhashi, Takeshi Takajo, Ryota Hokari, Akinori Wada, Kazuhiko Shirakabe, Hideki Ueno, Suguru Ito, Kengo Takeuchi, Kana Ayaki, Kazuki Horiuchi, Yoshinori Hanawa, Chikako Watanabe, Hideyuki Shimazaki, Nao Sugihara, Masaaki Higashiyama, Shunsuke Komoto, Akinori Mizoguchi
Publikováno v:
Internal Medicine
We herein present the case of an immunocompetent 63-year-old man who had previously undergone resection of Crohn's disease (CD)-related small intestinal obstruction more than 30 years ago. He had not been receiving any medication for many years, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5693512d637927a2d043677a2c57d329
https://doi.org/10.2169/internalmedicine.1687-18
https://doi.org/10.2169/internalmedicine.1687-18
Autor:
Kunio Shimizu, Hirotaka Furuhashi, Naoki Shibuya, Hiroyuki Toda, Chikako Watanabe, Shigeaki Nagao, Kengo Tomita, Shingo Enomoto, Kazuhiko Shirakabe, Yoshinori Hanawa, Nao Sugihara, Masaaki Higashiyama, Akinori Wada, Kazuki Horiuchi, Chie Kurihara, Takeshi Takajo, Ryota Hokari, Soichiro Miura, Yoshikiyo Okada, Shunsuke Komoto, Katsunori Kimura, Kenichi Inaba, Masaaki Tanichi, Hanae Tsuchihashi
Publikováno v:
Gut and Liver
Background/Aims: Although studies using conventional animal models have shown that specific stressors cause irritable bowel syndrome (IBS), it is unclear whether depression itself causes IBS. Our aim was to establish a rat model to determine if depre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1fa3688af65793a27c544126ef7f99
https://doi.org/10.5009/gnl18296
https://doi.org/10.5009/gnl18296
Autor:
Chikako Watanabe, Nao Sugihara, Masaaki Higashiyama, Rina Tanemoto, Michio Kubota, Hisato Terada, Shunsuke Komoto, Ryota Hokari, Masami Shinozaki, Takeshi Takajo, Shigeaki Nagao, Kengo Tomita, Shin Nishii, Daisuke Miyagishima, Akinori Wada, Shigeyoshi Soga, Yoshinori Hanawa, Nobuaki Gotoh, Kazuhiko Shirakabe, Akinori Mizoguchi, Hideki Ueno, Hirotaka Furuhashi, Suguru Ito, Kazuki Horiuchi, Soichiro Miura, Akihiko Nakagawa
Publikováno v:
Internal Medicine
We herein report a 44-year-old man suffering from systemic edema due to protein-losing enteropathy (PLE) with superior mesenteric vein (SMV) obstruction and development of collateral veins, which subsequently proved to be a chronic result of thrombos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bcee831cb7893a88e9b0f98d258d04
https://doi.org/10.2169/internalmedicine.1192-18
https://doi.org/10.2169/internalmedicine.1192-18
Autor:
Naoki Shibuya, Kazuhiko Shirakabe, Masayuki Saruta, Kazuki Horiuchi, Masaaki Higashiyama, Ryota Hokari
Publikováno v:
Journal of Visualized Experiments.
Naive lymphocytes recirculate from the blood to the lymphoid tissues under physiological condition and it is commonly recognized as an important phenomenon in the gut immunity. The stroma of secondary lymphoid organs, such as Peyer's patches (PPs) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d645be8533dab8b37aaeaa165a4bc2
https://doi.org/10.3791/61568-v
https://doi.org/10.3791/61568-v
Autor:
Toshiaki Ishizuka, Hirotaka Furuhashi, Masaaki Higashiyama, Chikako Watanabe, Soichiro Miura, Kazuhiko Shirakabe, Koji Maruta, Chie Kurihara, Shigeaki Nagao, Kengo Tomita, Ryota Hokari, Takeshi Takajo, Yoshikiyo Okada, Hideaki Hozumi, Shunsuke Komoto
Publikováno v:
Journal of Leukocyte Biology. 104:1013-1022
The enhanced recruitment of leukocytes to the inflamed colon is a key feature of ulcerative colitis (UC). The gut-specific adhesion molecules involved in leukocyte recruitment have emerged as recent therapeutic targets. Nicotine absorbed from smoking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de2737dda3cc152447a982837de0de8
https://doi.org/10.1002/jlb.3a0717-304r
https://doi.org/10.1002/jlb.3a0717-304r
Autor:
Soichiro Miura, Yoshikiyo Okada, Takeshi Takajo, Shunsuke Komoto, Chie Kurihara, Chikako Watanabe, Koji Maruta, Masaaki Higashiyama, Masayuki Saruta, Ryota Hokari, Kazuhiko Shirakabe, Shigeaki Nagao, Kengo Tomita, Hirotaka Furuhashi
Publikováno v:
Journal of Gastroenterology and Hepatology. 33:1608-1616
Background and aim Sphingosine-1-phosphate (S1P) receptor 1, a therapeutic target of the S1P1 agonist FTY720, plays a crucial role in lymphocyte migration and is expressed in several cells including naive T lymphocytes and endothelial cells. 2-Acetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9a6c888189ddae3e08f978ce4d92e58
https://doi.org/10.1111/jgh.14092
https://doi.org/10.1111/jgh.14092
Autor:
Kazuhiko Shirakabe, Shunsuke Komoto, Chie Kurihara, Ryota Hokari, Toshiaki Teratani, Makoto Nishikawa, Chikako Watanabe, Takeshi Takajo, Shigeaki Nagao, Kengo Tomita, Masaaki Higashiyama, Motonori Shimizu, Junji Yamamoto, Yoshikiyo Okada, Suefumi Aosasa, Soichiro Miura, Koji Maruta, Hirotaka Furuhashi
Publikováno v:
Hepatology Research. 48:397-407
Aim Liver fibrosis is a life-threatening disorder for which no approved therapy is available. Recently, we reported that mouse hepatic stellate cell (HSC) activation increased free cholesterol (FC) accumulation, partly by enhancing signaling through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c364251f98e59eb18e2eed31ca87ba3a
https://doi.org/10.1111/hepr.13040
https://doi.org/10.1111/hepr.13040
Autor:
Takeshi Takajo, Koji Maruta, Soichiro Miura, Shigeaki Nagao, Kengo Tomita, Keisuke Ikeyama, Akinori Mizoguchi, Shin Nishii, Shunsuke Komoto, Chikako Watanabe, Masaaki Higashiyama, Hisato Terada, Yuichi Yasutake, Hirotaka Furuhashi, Ryota Hokari, Kazuhiko Shirakabe
Publikováno v:
Internal Medicine
We herein describe a 69-year-old man suffering from chronic diarrhea caused by lansoprazole (LPZ)-induced collagenous colitis (CC) accompanied with protein-losing enteropathy (PLE), diagnosed by increased fecal alpha-1 antitrypsin clearance and the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7d8a5c119117c38c65f831ad420ec2
https://doi.org/10.2169/internalmedicine.8993-17
https://doi.org/10.2169/internalmedicine.8993-17