Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Kazuhiko, Okumura"'
Autor:
Roman Fukui, Ryo Saga, Yusuke Matsuya, Kazuo Tomita, Yoshikazu Kuwahara, Kentaro Ohuchi, Tomoaki Sato, Kazuhiko Okumura, Hiroyuki Date, Manabu Fukumoto, Yoichiro Hosokawa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Cancer stem-like cells (CSCs) within solid tumors exhibit radioresistance, leading to recurrence and distant metastasis after radiotherapy. To experimentally study the characteristics of CSCs, radioresistant cell lines were successfully esta
Externí odkaz:
https://doaj.org/article/b9f986bf3be149b6982973fd1e3addd7
Autor:
Kazuki Hasegawa, Ryo Saga, Kentaro Ohuchi, Yoshikazu Kuwahara, Kazuo Tomita, Kazuhiko Okumura, Tomoaki Sato, Manabu Fukumoto, Eichi Tsuruga, Yoichiro Hosokawa
Publikováno v:
Cells, Vol 11, Iss 23, p 3780 (2022)
Radioresistant (RR) cells are poor prognostic factors for tumor recurrence and metastasis after radiotherapy. The hyaluronan (HA) synthesis inhibitor, 4-methylumbelliferone (4-MU), shows anti-tumor and anti-metastatic effects through suppressing HA s
Externí odkaz:
https://doaj.org/article/e8f4a19d15614a2992999b86da318b05
Publikováno v:
Nihon Kikai Gakkai ronbunshu, Vol 86, Iss 892, Pp 20-00183-20-00183 (2020)
Electrolyzed water generator can produce acidic and alkaline water from tap water and electric power, and is expected to have applications in the food and medical fields for sterilization, cleaning and disinfection. However, there are still many unkn
Externí odkaz:
https://doaj.org/article/a0ff1e14bbec42dba596b6434ede4e03
Autor:
Kentaro Ohuchi, Ryo Saga, Kazuki Hasegawa, Eichi Tsuruga, Yoichiro Hosokawa, Manabu Fukumoto, Kazuhiko Okumura
Publikováno v:
Biomed Rep
Radioresistant cancer cells lead to poor prognosis after radiotherapy. However, the mechanisms underlying cancer cell radioresistance have not been fully elucidated. Thus, the DNA damage response of clinically relevant radioresistant oral squamous ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a31169dae750813c7e5efd9258794d
https://europepmc.org/articles/PMC10011949/
https://europepmc.org/articles/PMC10011949/
Publikováno v:
Transactions of the JSME (in Japanese). 86:20-00183
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2b031aaff7f280abb4b7ef34c28ddb0
https://doi.org/10.1299/transjsme.20-00183
https://doi.org/10.1299/transjsme.20-00183
Autor:
Kazuhiko Okumura
Publikováno v:
Japanese Dental Science Review, Vol 47, Iss 1, Pp 67-81 (2011)
The oral epithelium functions as a mechanical and protective barrier to resist bacterial infection. Several types of host defense peptides (HDPs), including defensins, cathelicidins, and histatins, may have important roles in innate host defense. HDP
Externí odkaz:
https://doaj.org/article/8298d3d1c1834307a7b61518ae979fe6
Autor:
Yoichiro Hosokawa, Rei Takahashi, Ryo Saga, Kazuhiko Okumura, Kazuki Hasegawa, Roman Fukui, Mitsuru Chiba, Eichi Tsuruga
Publikováno v:
Oncology Letters
The inflammatory response is closely associated with cancer cell survival. It has been reported that inflammatory signaling cascades promote tumor survival and exert detrimental effects in normal tissue. Hyaluronans have different cellular functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2b2b0ef2a55af448da1b94418ea932
https://doi.org/10.3892/ol.2020.11370
https://doi.org/10.3892/ol.2020.11370
Autor:
Yoichiro Hosokawa, Kazuki Hasegawa, Eichi Tsuruga, Toshiya Nakamura, Mitsuru Chiba, Ryo Saga, Kosho Murata, Kazuhiko Okumura
Publikováno v:
Oncology Letters.
Tumor recurrence and distant metastasis following radiotherapy, which can lead to poor prognosis, are caused by residual cancer cells that acquire radioresistance. Chemotherapy or a combination of targeted inhibitors can potentially enhance radiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3008e14add19ab6cadd0eef6b44e642d
https://doi.org/10.3892/ol.2019.9990
https://doi.org/10.3892/ol.2019.9990
Autor:
Kazuki Saito, Marija Krstic-Demonacos, Miwa Hayashi, Kazuhiko Okumura, Hiroshi Isogai, Kengo Kuroda, Emiko Isogai, Tomokazu Fukuda, Constantinos Demonacos
Publikováno v:
BMC Cancer
Kuroda, K, Fukuda, T, Krstic-Demonacos, M, Demonacos, C, Okumura, K, Isogai, H, Hayashi, M, Saito, K & Isogai, E 2017, ' miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway ', BMC Cancer . https://doi.org/10.1186/s12885-016-3003-9
Kuroda, K, Fukuda, T, Krstic-Demonacos, M, Demonacos, C, Okumura, K, Isogai, H, Hayashi, M, Saito, K & Isogai, E 2017, ' miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway ', BMC Cancer . https://doi.org/10.1186/s12885-016-3003-9
Background Antimicrobial peptides (AMPs) play important roles in the innate immune system of all life forms and recently have been characterized as multifunctional peptides that have a variety of biological roles such as anticancer agents. However, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f992d2f3d4e8181d2eebbc38885bb2
http://europepmc.org/articles/PMC5219750
http://europepmc.org/articles/PMC5219750
Autor:
KAZUKI HASEGAWA, RYO SAGA, REI TAKAHASHI, ROMAN FUKUI, MITSURU CHIBA, KAZUHIKO OKUMURA, EICHI TSURUGA, YOICHIRO HOSOKAWA
Publikováno v:
Oncology Letters; Apr2020, Vol. 19 Issue 4, p2801-2808, 8p