Zobrazeno 1 - 10
of 460
pro vyhledávání: '"Kazuhiko, Ohashi"'
Autor:
Tomohiro Okagawa, Satoru Konnai, Shinya Goto, Yamato Sajiki, Otgontuya Ganbaatar, Kei Watari, Hayato Nakamura, Cai-Xia Wang, Taro Tachibana, Yukinari Kato, Yayoi Kameda, Junko Kohara, Nobuhiro Terasaki, Manabu Kubota, Akira Takeda, Hirofumi Takahashi, Yasuhiko Suzuki, Naoya Maekawa, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
Veterinary Research, Vol 54, Iss 1, Pp 1-14 (2023)
Abstract Immune checkpoint molecules PD-1/PD-L1 cause T-cell exhaustion and contribute to disease progression in chronic infections of cattle. We established monoclonal antibodies (mAbs) that specifically inhibit the binding of bovine PD-1/PD-L1; how
Externí odkaz:
https://doaj.org/article/d1e0e81c1ed349c095a5bc6af2dd26e6
Autor:
Shwe Yee Win, Hikari Seo, Fumiya Horio, Sotaro Fujisawa, Jumpei Sato, Yoshinosuke Motai, Takumi Sato, Eiji Oishi, Akira Taneno, Lat Lat Htun, Saw Bawm, Tomohiro Okagawa, Naoya Maekawa, Satoru Konnai, Kazuhiko Ohashi, Shiro Murata
Publikováno v:
Vaccines, Vol 12, Iss 2, p 148 (2024)
Poultry red mites (Dermanyssus gallinae, PRMs), tropical fowl mites (Ornithonyssus bursa, TFMs), and northern fowl mites (O. sylviarum, NFMs) are blood-feeding pests that debilitate poultry worldwide. Glutathione S-transferase (GST) plays an importan
Externí odkaz:
https://doaj.org/article/cb77113d2ef0450a9f50d657494ebbd9
Autor:
Yoshinosuke Motai, Shiro Murata, Jumpei Sato, Akihito Nishi, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi
Publikováno v:
Veterinary Sciences, Vol 11, Iss 1, p 43 (2024)
Marek’s disease virus (MDV) causes malignant lymphoma (Marek’s disease; MD) in chickens. The Meq protein is essential for tumorigenesis since it regulates the expression of host and viral genes. Previously, we reported that the deletion of the sh
Externí odkaz:
https://doaj.org/article/207e8a781a2146a1b133c0b73bd98d6e
Autor:
Naoya Maekawa, Satoru Konnai, Yumie Asano, Yamato Sajiki, Tatsuya Deguchi, Tomohiro Okagawa, Kei Watari, Hiroto Takeuchi, Satoshi Takagi, Kenji Hosoya, Sangho Kim, Hiroshi Ohta, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Immune checkpoint inhibitors (ICIs) such as anti-PD-L1 antibodies are widely used to treat human cancers, and growing evidence suggests that ICIs are promising treatments for canine malignancies. However, only some canine oral malignant mela
Externí odkaz:
https://doaj.org/article/9195edeb9fe7415f92cb3f8d09b03d7b
Autor:
Shwe Yee Win, Shiro Murata, Sotaro Fujisawa, Hikari Seo, Jumpei Sato, Yoshinosuke Motai, Takumi Sato, Eiji Oishi, Akira Taneno, Lat Lat Htun, Saw Bawm, Tomohiro Okagawa, Naoya Maekawa, Satoru Konnai, Kazuhiko Ohashi
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionPoultry red mites (PRMs, Dermanyssus gallinae), blood-sucking ectoparasites, are a threat to the poultry industry because of reduced production caused by infestation. In addition, tropical fowl mites (TFMs, Ornithonyssus bursa) and northe
Externí odkaz:
https://doaj.org/article/3475bcac778149e187685f4e7f444c54
Autor:
Mari Ikehata, Satoru Konnai, Tomohiro Okagawa, Kentaro Abe, Mitsuru Honma, Toru Kitamura, Naoya Maekawa, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Calf diarrhea adversely affects growth and sometimes results in mortality, leading to severe economic losses to the cattle industry. Antibiotics are useful in the treatment against bacterial diarrhea, but not against viral, protozoan, and antibiotic-
Externí odkaz:
https://doaj.org/article/b1cf05cdd6024381a5df5ee2da20aa68
Autor:
Sotaro Fujisawa, Shiro Murata, Masayoshi Isezaki, Shwe Yee Win, Takumi Sato, Eiji Oishi, Akira Taneno, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi
Publikováno v:
Poultry Science, Vol 102, Iss 4, Pp 102532- (2023)
ABSTRACT: The poultry red mite (Dermanyssus gallinae, PRM) is a blood-sucking ectoparasite in chickens and is one of the most serious threats to poultry farms. Mass infestation with PRMs causes various health problems in chickens, resulting in signif
Externí odkaz:
https://doaj.org/article/5e64bcc88bba4851a72371614482db91
Autor:
Naoya Maekawa, Satoru Konnai, Kenji Hosoya, Sangho Kim, Ryohei Kinoshita, Tatsuya Deguchi, Ryo Owaki, Yurika Tachibana, Madoka Yokokawa, Hiroto Takeuchi, Yumiko Kagawa, Satoshi Takagi, Hiroshi Ohta, Yukinari Kato, Satoshi Yamamoto, Keiichi Yamamoto, Yasuhiko Suzuki, Tomohiro Okagawa, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0291727 (2023)
Immune checkpoint inhibitors (ICIs) have been developed for canine tumour treatment, and pilot clinical studies have demonstrated their antitumour efficacy in dogs with oral malignant melanoma (OMM). Although ICIs have been approved for various human
Externí odkaz:
https://doaj.org/article/295c408651194fcf866d2177d2d31e14
Autor:
Hiroto Takeuchi, Chie Nakajima, Satoru Konnai, Naoya Maekawa, Tomohiro Okagawa, Masaru Usui, Yutaka Tamura, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0281171 (2023)
Coagulase-positive Staphylococci express protein A, which binds to host antibodies, to evade the immune system. Taking advantage of its specific binding to antibodies, protein A from Staphylococcus aureus, which is called SpA, is commonly used as an
Externí odkaz:
https://doaj.org/article/15c9f77af22a444098030fbd9848f807
Autor:
Naoya Maekawa, Satoru Konnai, Yumie Asano, Takumi Otsuka, Eri Aoki, Hiroto Takeuchi, Yukinari Kato, Mika K Kaneko, Shinji Yamada, Yumiko Kagawa, Maki Nishimura, Satoshi Takagi, Tatsuya Deguchi, Hiroshi Ohta, Takayuki Nakagawa, Yasuhiko Suzuki, Tomohiro Okagawa, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0281143 (2023)
Spontaneous tumors are a major cause of death in cats. Treatment of human tumors has progressed dramatically in the past decade, partly due to the success of immunotherapies using immune checkpoint inhibitors, such as anti-programmed death 1 (PD-1) a
Externí odkaz:
https://doaj.org/article/3ac2e2ce926b4c96b347415a36673aec